Article(id=1291404559268705233, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1732464000000, receivedDateStr=2024-11-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824440065, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824440065, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824440065, creator=13701087609, updateTime=1785824440065, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=761, endPage=765, ext={EN=ArticleExt(id=1291404559507780562, articleId=1291404559268705233, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of flurbiprofen axetil combined with dezocine for postoperative PCIA analgesia in patients with intertrochanteric femoral fractures, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the analgesic effects and safety of flurbiprofen axetil injection combined with dezocine injection in postoperative patient-controlled intravenous analgesia (PCIA) for patients with intertrochanteric femoral fractures (IFF).
Methods IFF patients were divided into control group and treatment group based on cohort method. The control group was given 0.5 mg·kg-1 dezocine injection diluted with 100 mL of 0.9% NaCl and then injected with analgesic pump. The treatment group was given 1.0 mg·kg-1 flurbiprofen axetil injection + 0.3 mg·kg-1 dezocine injection diluted with 100 mL of 0.9% NaCl and then injected with analgesic pump Postoperative visual analog scale (VAS), Ramsay sedation score (RSS), mini-mental state examination (MMSE), hemodynamic parameters (heart rate, mean arterial pressure), and safety evaluations were compared between the two groups.
Results A total of 67 patients were enrolled in the control group; and 53 patients were enrolled in the treatment group. Postoperative VAS scores at 2, 12 and 24 h were (1.95±0.39), (2.52±0.31) and (2.21±0.40) points in the treatment group, and (2.47±0.44), (3.17±0.34) and (2.76±0.37) points in the control group. RSS scores at the same time were (3.15±0.33), (3.39±0.35) and (3.72±0.46) points for the treatment group, and (2.79±0.54), (3.16±0.43) and (3.28±0.68) points for the control group. MMSE scores at 1, 3, and 7 days postoperatively were (25.08±2.40), (26.80±2.01) and (27.64±2.59) points in the treatment group, and (22.36±2.24), (24.53±2.25) and (25.37±1.84) points in the control group. Thirty minutes after surgery, the heart rate was (86.61±4.80) beat·min-1 in the treatment group and (82.74±4.17) beat·min-1 in the control group, while the mean arterial pressure was (74.28±4.49) mmHg and (71.76±3.42) mmHg, respectively. These indicators in the treatment group showed statistically significant differences compared to the control group (all P<0.05). The main adverse drug reactions in the treatment group were dizziness, fatigue, drowsiness, and nausea/vomiting, while the control group also had respiratory depression in addition to dizziness, fatigue, drowsiness, and nausea/vomiting. The total incidence of adverse drug reactions was 7.55% (4 cases/53 cases) in the treatment group and 20.90% (14 cases/67 cases) in the control group, with statistically significant difference (P<0.05).
Conclusion Flurbiprofen axetil injection combined with dezocine injection for postoperative PCIA in IFF patients provides superior analgesic and sedative effects compared to dezocine monotherapy, enhances cognitive function, stabilizes hemodynamics, and has good safety.
, authors=Hong-zhen CHENG, Cao-sheng LAI, Zhi-ping ZHOU, authorsList=Hong-zhen CHENG, Cao-sheng LAI, Zhi-ping ZHOU, authorCompany=null, correspAuthors=Hong-zhen CHENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404559855907795, articleId=1291404559268705233, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=氟比洛芬酯联合地佐辛用于股骨粗隆间骨折患者术后PCIA的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察氟比洛芬酯注射液联合地佐辛注射液用于股骨粗隆间骨折（IFF）患者术后自控静脉镇痛（PCIA）的镇痛效果和安全性。
方法 将IFF患者根据队列法分为对照组和试验组。对照组患者给予0.5 mg·kg-1地佐辛注射液，用0.9% NaCl 100 mL稀释后用镇痛泵输注。试验组患者给予1.0 mg·kg-1氟比洛芬酯注射液+0.3 mg·kg-1地佐辛注射液，用0.9% NaCl 100 mL稀释后用镇痛泵输注。比较2组患者术后视觉模拟量表（VAS）、Ramsay镇静评分量表（RSS）、简易智力精神状态检查量表（MMSE）评分、血流动力学指标（心率、平均动脉压水平），以及进行安全性评价。
结果 对照组入组67例，试验组入组53例。试验组术后2、12和24 h时的VAS评分分别为（1.95±0.39）、（2.52±0.31）和（2.21±0.40）分，对照组术后2、12和24 h时的VAS评分分别为（2.47±0.44）、（3.17±0.34）和（2.76±0.37）分；试验组术后2、12和24 h时的RSS评分分别为（3.15±0.33）、（3.39±0.35）和（3.72±0.46）分，对照组术后2、12和24 h时的RSS评分分别为（2.79±0.54）、（3.16±0.43）和（3.28±0.68）分；试验组术后1、3和7 d时的MMSE评分分别为（25.08±2.40）、（26.80±2.01）和（27.64±2.59）分，对照组术后1、3和7 d时的MMSE评分分别为（22.36±2.24）、（24.53±2.25）和（25.37±1.84）分；试验组和对照组术后30 min时心率的（86.61±4.80）和（82.74±4.17）beat·min-1，平均动脉压分别为（74.28±4.49）和（71.76±3.42）mmHg。试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要有头晕乏力、嗜睡、恶心呕吐，对照组的药物不良反应主要有头晕乏力、嗜睡、恶心呕吐、呼吸抑制。试验组和对照组的药物不良反应总发生率分别为7.55%（4例/53例）和20.90%（14例/67例），在统计学上差异有统计学意义（P<0.05）。
结论 氟比洛芬酯注射液联合地佐辛注射液用于IFF患者术后PCIA相比地佐辛单药镇痛，可以提高镇痛镇静效果，增强认知功能，稳定血流动力学，且安全性好。
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程宏振（1983-），男，副主任医师，主要从事骨科方向的临床诊疗工作
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