Article(id=1291404459935003321, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729699200000, receivedDateStr=2024-10-24, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824416382, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824416382, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824416382, creator=13701087609, updateTime=1785824416382, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=696, endPage=700, ext={EN=ArticleExt(id=1291404460098581178, articleId=1291404459935003321, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of hydroxylsafflower yellow A on epiphyseal injury of tibial bone in rats through neurotrophin-3, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To study the effect of hydroxylsafflower yellow A (HSYA) on epiphyseal injury of tibial in rats through neurotrophic factor-3 (NT-3).
Methods Fifty male SD rats were randomly divided into control group, model group, HSYA group, NC group and sh-NT-3 group, with 10 rats in each group. Except the control group, the injury model of tibial epiphyseal was established in the other 4 groups by high speed dental abrasive drill. The HSYA group was given 10 mg·kg-1 HSYA by intragastric administration once a day for 6 weeks. NC group and sh-NT-3 group were respectively injected with 1 mg·kg-1 sh-NC and sh-NT-3 through the tail vein, once every two days for 6 weeks. The control group and model group were given the same amount of normal saline intragastric and caudal intravenous injection. Quantitative real-time polymerase chain reaction was used to detect the expression level of NT-3 mRNA. The expression levels of bone repair markers and Notch receptor 1 (Notch1) signaling pathway related proteins were detected by Western blot.
Results The mRNA levels of NT-3 in control group, model group and HSYA group were 1.00±0.17, 3.31±0.59 and 5.16±0.84, respectively. The relative expression of runt related transcription factor 2 protein in control group, model group, HSYA group, NC group and sh-NT-3 group were 1.00±0.17, 3.67±0.63, 7.36±1.35, 7.31±1.42, 5.74±1.32, respectively; the relative expressions of osteoblast-specific transcription factor protein were 1.00±0.18, 5.76±1.01, 8.49±1.42, 8.56±1.54, 6.48±1.16, respectively; the relative expressions of Notch1 protein were 1.00±0.18, 1.44±0.23, 1.79±0.34, 1.83±0.35, 1.52±0.27, respectively. The above indexes in the model group were compared with the control group, the HSYA group was compared with the model group, and the sh-NT-3 group was compared with the NC group, and the above indexes were statistically significant (all P<0.05).
Conclusion HSYA improves tibial epiphyseal injury in rats by promoting NT-3 expression and activating Notch1 signaling pathway.
, authors=Xiao-chun REN, Wen-bin LI, Zhi-zhong ZHAO, Jia LÜ, Yong-bo HUANG, authorsList=Xiao-chun REN, Wen-bin LI, Zhi-zhong ZHAO, Jia LÜ, Yong-bo HUANG, authorCompany=null, correspAuthors=Yong-bo HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404460379599547, articleId=1291404459935003321, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=羟基红花黄色素A通过神经营养因子-3对大鼠胫骨骨骺损伤的作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究羟基红花黄色素A（HSYA）通过神经营养因子-3（NT-3）对大鼠胫骨骨骺损伤的影响机制。
方法 将50只雄性SD大鼠随机分为对照组、模型组、HSYA组、NC组和sh-NT-3组，每组10只。除对照组外，其余4组均用高速牙钻建立胫骨骨骺损伤模型。HSYA组灌胃给予10 mg·kg-1 HSYA，qd，连续6周；NC组和sh-NT-3组分别在HSYA组的基础上尾静脉注射1 mg·kg-1 sh-NC和sh-NT-3，每2天1次，连续6周。对照组和模型组给予等量的0.9% NaCl灌胃和尾静脉注射。用实时定量反转录聚合酶链反应检测NT-3 mRNA相对表达水平，用蛋白质印迹法检测骨修复标志物和Notch通路关键基因Notch受体1（Notch1）信号通路相关蛋白的相对表达水平。
结果 对照组、模型组、HSYA组的NT-3 mRNA相对表达水平分别为1.00±0.17、3.31±0.59和5.16±0.84；对照组、模型组、HSYA组、NC组和sh-NT-3组的Runt相关转录因子2蛋白相对表达水平分别为1.00±0.17、3.67±0.63、7.36±1.35、7.31±1.42和5.74±1.32，成骨细胞特异性转录因子蛋白相对表达水平分别为1.00±0.18、5.76±1.01、8.49±1.42、8.56±1.54和6.48±1.16，Notch1蛋白相对表达水平分别为1.00±0.18、1.44±0.23、1.79±0.34、1.83±0.35和1.52±0.27。模型组的上述指标与对照组比较，HSYA组的上述指标与模型组比较，sh-NT-3组的上述指标与NC组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 HSYA通过促进NT-3表达，激活Notch1信号通路改善大鼠胫骨骨骺损伤。
, authors=任晓春, 李文斌, 赵致忠, 吕嘉, 黄永波, authorsList=任晓春, 李文斌, 赵致忠, 吕嘉, 黄永波, authorCompany=null, correspAuthors=黄永波, authorNote=
任晓春（1985-），男，主治医师，主要从事骨科方面工作和研究
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任晓春（1985-），男，主治医师，主要从事骨科方面工作和研究
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