Article(id=1291404444277666362, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728662400000, receivedDateStr=2024-10-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824412650, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824412650, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824412650, creator=13701087609, updateTime=1785824412650, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=611, endPage=615, ext={EN=ArticleExt(id=1291404444449632827, articleId=1291404444277666362, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of salmeterol fluticasone propionate in the treatment of children with cough variant asthma, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the clinical efficacy and safety of salmeterol fluticasone propionate combined with cetirizine hydrochloride and montelukast sodium tablet in the treatment of children with cough variant asthma.
Methods The children with cough variant asthma were divided into control group and treatment group by random number table method. The control group was treated with oral montelukast sodium chewable tablets and cetirizine hydrochloride oral solution, both 10 mg every time, qd; the treatment group was treated with salmeterol fluticasone propionate inhalation powder inhalation, 1 inhalation/time, bid on the basis of the control group. Children in both groups continued treatment for 3 weeks. The clinical efficacy, pulmonary function, airway reaction status, immune function index, inflammatory index and adverse drug reactions were compared between the two groups.
Results In the treatment group, 50 cases were enrolled, 1 case was lost, and 49 cases were finally included in the statistical analysis. In the control group, 52 cases were enrolled, 3 cases were lost, and finally 49 cases were included in the statistical analysis. After treatment, the total effective rate of the control group and the treatment group were 77.55% (38 cases/49 cases) and 93.88% (46 cases/49 cases), respectively, and the difference were statistically significant (P<0.05). After treatment, the maximum expiratory flow were (4.68±0.56) and (5.07±0.62) L·s-1 in the control and treatment groups; the vital capacity were (0.98±0.05) and (1.02±0.07) L; the forced expiratory volume in the first second were (75.72±7.24)% and (80.03±8.36)%; the forced vital capacity were (75.49±7.68)% and (79.97±6.72)%; the initial airway resistance were (7.33±0.75) and (7.01±0.73) cm H2O·L-1·s-1; the minimum induced cumulative dose were (1.89±0.14) and (2.01 ± 0.25) mg·L-1; the 35th percentile of specific airway conduction decrease were (5.24±0.52)% and (5.59±0.68)%. There were statistically significant differences in the above indexes between the treatment group and the control group (P<0.05, P<0.01, P<0.001). The adverse drug reactions of the control group and the treatment group were headache, palpitation and sleep difficulty, and the incidence of the total adverse drug reactions of the treatment group and the control group were 6.12% (3 cases /49 cases) and 12.24% (6 cases /49 cases), respectively, with no statistical significance (P>0.05).
Conclusion Salmeterol fluticasone propionate, cetirizine hydrochloride and montelukast sodium tablet are effective and safe in the treatment of children with cough variant asthma.
, authors=Xin-feng GE, Lei SONG, authorsList=Xin-feng GE, Lei SONG, authorCompany=null, correspAuthors=Lei SONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404444801954364, articleId=1291404444277666362, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=沙美特罗替卡松治疗儿童咳嗽变异性哮喘的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察沙美特罗替卡松吸入粉雾剂联合盐酸西替利嗪口服液和孟鲁司特钠咀嚼片治疗儿童咳嗽变异性哮喘的临床疗效及安全性。
方法 将咳嗽变异性哮喘患儿随机分为对照组和试验组。对照组给予孟鲁司特钠咀嚼片口服，每次10 mg，qd，盐酸西替利嗪口服液口服，每次10 mg，qd；试验组在对照组治疗的基础上，联合沙美特罗替卡松吸入粉雾剂吸入治疗，每次1吸，bid。2组患儿均持续治疗3周。比较2组患儿的临床疗效、肺功能、气道反应状态、免疫功能指标、炎性指标，以及安全性。
结果 试验组入组50例，脱落1例，最终有49例纳入统计分析；对照组入组52例，脱落3例，最终有49例纳入统计分析。治疗后，对照组和试验组的总有效率分别为77.55%（38例/49例）和93.88%（46例/49例），在统计学上差异有统计学意义（P<0.05）。治疗后，对照组和试验组最大呼气流量分别为（4.68±0.56）和（5.07±0.62）L·s-1，肺活量分别为（0.98±0.05）和（1.02±0.07）L，第1秒用力呼气容积分别为（75.72±7.24）%和（80.03±8.36）%，用力肺活量分别为（75.49±7.68）%和（79.97±6.72）%，气道初始阻力分别为（7.33±0.75）和（7.01±0.73）cm H2O·L-1·s-1，最小诱发累计剂量分别为（1.89±0.14）和（2.01±0.25）mg·L-1，特异性气道传导下降第35百分位分别为（5.24±0.52）%和（5.59±0.68）%，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）。2组患儿的药物不良反应均以头痛、心悸、入睡困难为主，试验组和对照组的总药物不良反应发生率分别为6.12%（3例/49例）和12.24%（6例/49例），在统计学上差异无统计学意义（P>0.05）。
结论 沙美特罗替卡松吸入粉雾剂联合盐酸西替利嗪口服液和孟鲁司特钠咀嚼片治疗儿童咳嗽变异性哮喘的临床疗效显著，安全性高。
, authors=葛新峰, 宋磊, authorsList=葛新峰, 宋磊, authorCompany=null, correspAuthors=宋磊, authorNote=
葛新峰（1994-），男，医师，主要从事儿科相关疾病临床诊疗方面的工作
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