Article(id=1291404439626183181, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1727107200000, receivedDateStr=2024-09-24, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824411540, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824411540, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824411540, creator=13701087609, updateTime=1785824411540, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=681, endPage=685, ext={EN=ArticleExt(id=1291404439882035729, articleId=1291404439626183181, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of tazemetostat on stem and proliferation of diffuse large B-cell lymphoma and its mechanism of action, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To study the effect of tazemetostat on the stemness of diffuse large B-cell lymphoma and the related mechanism of action.
Methods OCI-LY3 cells were divided into blank group, tazemetostat group and microRNA-378a-3p (miR-378a-3p) mimics group. Blank group cell conventional culture; tazemetostat group was treated with 5 μmol·L-1 tazemetostat; miR-378a-3p mimics group was transfected with miR-378a-3p mimics. The relative expression level of miR-378a-3p was detected by fluorescence in situ hybridization. mRNA expression levels of dryness related factors were detected by quantitative real time polymerase chain reaction; the expression of signal pathway-related proteins was detected by Western blot.
Results The relative expression levels of miR-378a-3p in blank group and tazemetostat group were 1.00±0.14 and 0.52±0.08, respectively, the difference was statistically significant (P<0.001). The relative expression of octamer binding transcription factor 4 mRNA in blank group, tazemetostat group and miR-378a-3p mimics group were 1.00±0.16, 0.21±0.06 and 0.49±0.08, respectively; the relative expression of sex determining region Y box protein 2 mRNA were 1.00±0.09, 0.39±0.05 and 0.85±0.11, respectively; the relative expression of Nanog homeobox mRNA were 1.00±0.13, 0.17±0.03 and 0.65±0.10, respectively; the relative expressions of Kruppel like factor 4 mRNA were 1.00±0.10, 0.28±0.05 and 0.86±0.14, respectively; the relative expressions of Yes associated protein were 1.00±0.19, 3.46±0.52 and 2.14±0.36, respectively; the relative expression of transcriptional coactivator with PDZ-binding motif protein were 1.00±0.14, 1.90±0.35 and 1.51±0.33, respectively. The above indexes of tazemetostat group were compared with those of blank group, and the above indexes of miR-378a-3p mimics group were compared with those of tazemetostat group, the differences were statistically significant (P<0.001, P<0.05).
Conclusion Tazemetostat can inhibit the stemness of OCI-LY3 cells by down-regulating the level of miR-378a-3p, which may be achieved through the Yes associated protein/transcriptional coactivator with PDZ-binding motif signaling pathway.
, authors=Qi CHEN
1a, Qun-yi PENG
1b, Yan HAN
1a, 1c, Li-de WU
1a, authorsList=Qi CHEN, Qun-yi PENG, Yan HAN, Li-de WU, authorCompany=null, correspAuthors=Li-de WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404440200802834, articleId=1291404439626183181, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=他泽司他对弥漫大B细胞淋巴瘤干性和增殖的影响及其作用机制研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究他泽司他对弥漫大B细胞淋巴瘤干性的影响，及其相关作用机制。
方法 将OCI-LY3细胞分为空白组、他泽司他组和微小RNA-378a-3p（miR-378a-3p）mimics组。空白组细胞常规培养；他泽司他组用5 μmol·L-1他泽司他处理；miR-378a-3p mimics组转染miR-378a-3p模拟物。用荧光原位杂交检测miR-378a-3p相对表达水平，用实时定量聚合酶链反应法检测干性相关因子信使核糖核酸（mRNA）相对表达水平，用蛋白质印迹法检测信号通路相关蛋白的相对表达水平。
结果 空白组和他泽司他组的miR-378a-3p相对表达水平分别为1.00±0.14和0.52±0.08，在统计学上差异有统计学意义（P<0.001）。空白组、他泽司他组和miR-378a-3p mimics组的八聚体结合转录因子4 mRNA相对表达水平分别为1.00±0.16、0.21±0.06和0.49±0.08，性别决定区Y框蛋白2 mRNA相对表达水平分别为1.00±0.09、0.39±0.05和0.85±0.11，Nanog同源框mRNA相对表达水平分别为1.00±0.13、0.17±0.03和0.65±0.10，Kruppel样因子4 mRNA相对表达水平分别为1.00±0.10、0.28±0.05和0.86±0.14，Yes相关蛋白相对表达水平分别为1.00±0.19、3.46±0.52和2.14±0.36，转录辅激活因子复合物蛋白相对表达水平分别为1.00±0.14、1.90±0.35和1.51±0.33。他泽司他组的上述指标与空白组比较，miR-378a-3p mimics组的上述指标与他泽司他组比较，在统计学上差异均有统计学意义（P<0.001，P<0.05）。
结论 他泽司他可以通过下调miR-378a-3p水平，抑制OCI-LY3细胞干性，这可能是通过Yes相关蛋白/转录辅激活因子复合物信号通路实现的。
, authors=陈琦
1a, 彭群艺
1b, 韩妍
1a, 1c, 吴立徳
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陈琦（1982-），男，主治医师，主要从事淋巴瘤、白血病方面的相关研究
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