Article(id=1291404408311509377, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1727020800000, receivedDateStr=2024-09-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824404075, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824404075, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824404075, creator=13701087609, updateTime=1785824404075, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=626, endPage=630, ext={EN=ArticleExt(id=1291404408772882818, articleId=1291404408311509377, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of remazolam combined with alfentanil in the treatment of patients with hysteroscopic surgery, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the anesthetic effects and safety of remazolam injection combined with alfentanil injection in the treatment of patients with hysteroscopic surgery.
Methods Patients scheduled for hysteroscopic surgery were randomly divided into control group and treatment group. The control group received intravenous 1.5-2.0 mg·kg-1 propofol + 7-10 μg·kg-1 alfentanil for anesthetic induction, during the surgery, continuously infused with 4-12 mg·kg-1·h-1 propofol + 0.05-0.20 μg·kg-1·h-1 remifentanil for anesthesia maintenance. The treatment group was given intravenous 0.3-0.5 mg·kg-1 remimazolam + 7-10 μg·kg-1 alfentanil for anesthetic induction, during the surgery, received 0.5-1.0 mg·kg-1·h-1remazolam+ 0.05-0.20 μg·kg-1·h-1 remifentanil for anesthesia maintenance. The hemodynamics, analgesic effects, cognitive function and safety were compared between the two groups.
Results Control group were enrolled 52 cases, 3 cases dropped out, and 49 cases were finally included in the statistical analysis. Treatment group were enrolled 53 cases, 4 cases dropped out, and 49 cases were finally included in the statistical analysis. At the end of the surgery, the mean arterial pressure of treatment and control groups were (73.98±7.41) and (60.10±6.84) mmHg, the heart rates were (68.43±7.32) and (63.92±7.36) beat·min-1, the differences of above index were statistically significant between two groups (all P<0.05). One hour after operation, the visual analogue scale scores of treatment and control groups were (3.08±0.49) and (3.86±0.61) points, the mini-mental state examination scores were (22.65±2.41) and (18.24±2.38) points, the differences were statistically significant (all P<0.05). The adverse drug reactions of treatment group were nausea, while those in the control group were bradycardia, hypotension, respiratory depression and nausea. The total incidences of adverse drug reactions in the treatment and control groups were 2.04% and 14.29%, with statistically significant difference (P<0.05).
Conclusion Remazolam injection combined with alfentanil injection can help to maintain hemodynamics of patients with hysteroscopic surgery, reduce the risk of postoperative pain and cognitive impairment, with good safety.
, authors=Ke-lu XU, Qin SHEN, Tong WU, Yue CHENG, authorsList=Ke-lu XU, Qin SHEN, Tong WU, Yue CHENG, authorCompany=null, correspAuthors=Ke-lu XU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404410756788611, articleId=1291404408311509377, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=瑞马唑仑联合阿芬太尼用于宫腔镜手术患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察瑞马唑仑注射液联合阿芬太尼注射液用于宫腔镜手术患者的麻醉效果及安全性。
方法 将拟接受宫腔镜手术患者随机分为对照组和试验组。对照组给予静脉注射1.5~2.0 mg·kg-1丙泊酚和7~10 μg·kg-1阿芬太尼进行麻醉诱导，术中持续泵注4~12 mg·kg-1·h-1丙泊酚和0.05~0.20 μg·kg-1·h-1瑞芬太尼进行麻醉维持；试验组给予静脉注射0.3~0.5 mg·kg-1瑞马唑仑和7~10 μg·kg-1阿芬太尼进行麻醉诱导，术中持续泵注0.5~1.0 mg·kg-1·h-1瑞马唑仑和0.05~0.20 μg·kg-1·h-1瑞芬太尼进行麻醉维持。比较2组患者的血流动力学、镇痛效果、认知功能，以及安全性。
结果 对照组入组52例，脱落3例，最终有49例纳入统计分析；试验组入组53例，脱落4例，最终有49例纳入统计分析。术毕时，试验组和对照组的平均动脉压分别为（73.98±7.41）和（60.10±6.84）mmHg，心率分别为（68.43±7.32）和（63.92±7.36）beat·min-1，在统计学上差异均有统计学意义（均P<0.05）。术后1 h，试验组和对照组的视觉模拟量表评分分别为（3.08±0.49）和（3.86±0.61）分，简易智能精神状态量表评分分别为（22.65±2.41）和（18.24±2.38）分，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应有恶心，对照组的药物不良反应主要有心动过缓、低血压、呼吸抑制、恶心。试验组和对照组的总药物不良反应发生率分别为2.04%和14.29%，在统计学上差异有统计学意义（P<0.05）。
结论 瑞马唑仑注射液联合阿芬太尼注射液有助于维持宫腔镜手术患者的血流动力学，降低术后疼痛和认知障碍的风险，且安全性较好。
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许克路（1978-），男，副主任医师，主要从事麻醉医学的临床诊疗工作
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