Article(id=1291404407481029473, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729699200000, receivedDateStr=2024-10-24, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824403877, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824403877, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824403877, creator=13701087609, updateTime=1785824403877, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=654, endPage=659, ext={EN=ArticleExt(id=1291404407833351010, articleId=1291404407481029473, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of ursodeoxycholic acid on bronchial epithelial cell injury induced by toluene diisocyanate, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect and mechanism of ursodeoxycholic acid on bronchial epithelial cell injury induced by toluene diisocyanate (TDI).
Methods BEAS-2B cells were randomly divided into control group (conventional culture), TDI-human serum albumin (HSA) group (120.00 mg·L-1 TDI-HSA), low-dose group (100 μmol·L-1 ursodeoxycholic acid+120.00 mg·L-1 TDI-HSA), high-dose group (200 μmol·L-1 ursodeoxycholic acid+120.00 mg·L-1 TDI-HSA) and rapamycin group (25 nmol·L-1 rapamycin+120.00 mg·L-1 TDI-HSA). The expression of inflammatory factors was detected by real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA); the level of reactive oxygen species (ROS) was detected by DCFH-DA; and the protein expression of each cell was detected by Western blot.
Results The mRNA levels of interleukin (IL)-6 in control group, TDI-HSA group, low-dose group and high-dose group were 1.00±0.13, 2.20±0.24, 1.87±0.12, 1.48±0.14, respectively; IL-8 levels were (22.65±1.96), (81.42±6.35), (56.36±5.88), (38.28±3.25) pg·mL-1, respectively; ROS levels were (100.00±3.47)%, (351.25±22.52)%, (312.80±26.59)%, (242.15±13.60)%, respectively; the protein levels of dynamic associated protein 1 (DRP1) were 0.23±0.03, 0.82±0.08, 0.69±0.10, 0.55±0.05, respectively; benzyl chloride 1 (Beclin1) protein expression levels were 0.23±0.04, 0.60±0.07, 0.44±0.04, 0.37±0.03, respectively; phosphorylated adenylate activates protein kinase (p-AMPK) protein expression levels were 0.20±0.05, 0.49±0.05, 0.40±0.03, 0.34±0.04, respectively. Beclin1 protein expression levels in high-dose group and rapamycin group were 0.35±0.04 and 0.69±0.07, respectively; IL-6 levels were (17.63±1.36) and (29.52±3.49) pg·mL-1, respectively; IL-18 levels were (65.22±5.30) and (95.58±6.80) pg·mL-1, respectively. The above indexes: TDI-HSA group was compared with control group, low- dose group and high- dose group were compared with TDI-HSA group, rapamycin group compared with high dose group, the differences were significant (all P<0.05).
Conclusion Ursodeoxycholic acid may mediate ROS/AMPK/ autophagy pathway to improve the inflammatory response and mitochondrial dysfunction induced by TDI-HSA.
, authors=Yan-ping NI, Jian-bin SU, authorsList=Yan-ping NI, Jian-bin SU, authorCompany=null, correspAuthors=Yan-ping NI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404408282141539, articleId=1291404407481029473, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=熊去氧胆酸改善甲苯二异氰酸酯诱导的支气管上皮细胞损伤的作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨熊去氧胆酸改善甲苯二异氰酸酯（TDI）诱导的支气管上皮细胞损伤的作用及机制。
方法 将BEAS-2B细胞随机分为对照组（常规培养）、TDI-人血清白蛋白（HSA）组（120.00 mg·L-1 TDI-HSA）、低剂量组（100 μmol·L-1熊去氧胆酸+120.00 mg·L-1 TDI-HSA）、高剂量组（200 μmol·L-1熊去氧胆酸+120.00 mg·L-1 TDI-HSA）、西罗莫司组（25 nmol·L-1西罗莫司+120.00 mg·L-1 TDI-HSA）。用实时荧光定量聚合酶链反应、酶联免疫吸附试验法检测细胞炎性因子的表达，用DCFH-DA法检测活性氧（ROS）水平，用蛋白质印迹实验检测各细胞蛋白的相对表达水平。
结果 对照组、TDI-HSA组、低剂量组和高剂量组的白细胞介素（IL）-6 mRNA相对表达水平分别为1.00±0.13、2.20±0.24、1.87±0.12和1.48±0.14，IL-8水平分别为（22.65±1.96）、（81.42±6.35）、（56.36±5.88）和（38.28±3.25）pg·mL-1，ROS水平分别为（100.00±3.47）%、（351.25±22.52）%、（312.80±26.59）%和（242.15±13.60）%，线粒体动力相关蛋白1（DRP1）蛋白相对表达水平分别为0.23±0.03、0.82±0.08、0.69±0.10和0.55±0.05，苄氯素1（Beclin1）蛋白相对表达水平分别为0.23±0.04、0.60±0.07、0.44±0.04和0.37±0.03，磷酸化腺苷酸活化蛋白激酶（p-AMPK）蛋白相对表达水平分别为0.20±0.05、0.49±0.05、0.40±0.03和0.34±0.04；高剂量组和西罗莫司组的Beclin1蛋白相对表达水平分别为0.35±0.04和0.69±0.07，IL-6水平分别为（17.63±1.36）和（29.52±3.49）pg·mL-1，IL-18水平分别为（65.22±5.30）和（95.58±6.80）pg·mL-1。TDI-HSA组的上述指标与对照组比较，低、高剂量组的上述指标分别与TDI-HSA组比较，西罗莫司组的上述指标与高剂量组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 熊去氧胆酸可能介导ROS/AMPK/自噬通路改善TDI-HSA诱发的炎症反应和线粒体功能障碍。
, authors=倪衍平, 苏健斌, authorsList=倪衍平, 苏健斌, authorCompany=null, correspAuthors=倪衍平, authorNote=
倪衍平（1983-），男，主管药师，主要从事临床药理、基础药理学方面的研究
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