Article(id=1291404402812772746, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728921600000, receivedDateStr=2024-10-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824402763, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824402763, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824402763, creator=13701087609, updateTime=1785824402763, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=621, endPage=625, ext={EN=ArticleExt(id=1291404403072819595, articleId=1291404402812772746, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of dydrogesterone combined with estradiol valerate for prevention of uterine readhesion after IUA, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the effect and safety of dydrogesterone combined with estradiol valerate on preventing the intrauterine re-adhesion after intrauterine adhesion (IUA) surgery.
Methods The patients after IUA surgery were divided into control group and treatment group according to the cohort method. The control group was given oral estradiol valerate tablets (2 mg every time, twice a day) immediately after surgery and stopped after 30 days of continuous oral administration, and on the basis of the control group; the treatment group received dydrogesterone tablets (10 mg each time, once a day) from the 20th day until the next menstruation. Both groups were treated for 2 menstrual cycles. The efficacy, endometrial receptivity ultrasound parameters [endometrial thickness, endometrial volume, vascular index (VI), blood flow index (FI), vascular blood flow index (VFI)], sex hormones [estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH)], adverse reactions and occurrence of re-adhesion were compared between the two groups.
Results Forty-eight cases in treatment group and 44 cases in control group were finally included. After 2 menstrual cycles of treatment, the total effective rates in treatment group and control group were 95.83% (46 cases/48 cases) and 81.82% (36 cases/44 cases), respectively (P<0.05). After 2 menstrual cycles of treatment, the endometrial thicknesses in treatment group and control group were (7.88±1.02) and (7.12±0.86) mm; the endometrial volumes were (3.02±0.97) and (2.57±0.73) cm3; VI values were 1.21±0.59 and 0.88±0.57; FI values were 29.87±5.12 and 27.56±4.63; VFI values were 1.12±0.43 and 0.83±0.36; E2 levels were (239.62±25.47) and (168.91±20.12) pmol·L-1; FSH levels were (8.94±2.02) and (10.63±2.14) U·L-1; LH levels were (13.38±2.16) and (15.27±2.59) U·L-1, respectively (all P<0.05). The adverse drug reactions in treatment group were mainly breast tenderness and digestive tract discomfort; and the adverse drug reactions in control group were mainly breast tenderness, digestive tract discomfort and headache. The total incidence rates of adverse drug reactions in treatment group and control group were 14.58% (7 cases/48 cases) and 11.36% (5 cases/44 cases), respectively (P>0.05). The incidence rates of re-adhesion in treatment group and control group were 6.25% (3 cases/48 cases) and 20.45% (9 cases/44 cases) (P<0.05).
Conclusion Dydrogesterone combined with estradiol valerate has a significant effect on preventing intrauterine re-adhesion after IUA surgery, and it can effectively improve the endometrial receptivity and sex hormones levels of patients, and it has medication safety.
, authors=Yan NIAN
1a, Jia-wen ZHONG
2, Xiao-rong LI
1b, authorsList=Yan NIAN, Jia-wen ZHONG, Xiao-rong LI, authorCompany=null, correspAuthors=Xiao-rong LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404403412558221, articleId=1291404402812772746, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=地屈孕酮联合戊酸雌二醇预防IUA术后宫腔再粘连的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察地屈孕酮片联合戊酸雌二醇片预防宫腔粘连（IUA）术后宫腔再粘连的临床疗效及安全性。
方法 将IUA分离手术后患者按照队列法分为对照组和试验组。对照组患者术后立即予戊酸雌二醇片，每次2 mg，bid，口服，连用30 d后停药；试验组在对照组治疗的基础上，自第20天给予地屈孕酮片，每次10 mg，qd，口服，至下次月经来潮。2组患者疗程均为2个月经周期。比较2组患者的临床疗效、子宫内膜容受性超声参数[子宫内膜厚度、子宫内膜体积、血管指数（VI）、血流指数（FI）、血管血流综合指数（VFI）]、血清性激素[雌二醇（E2）、卵泡刺激素（FSH）、黄体生成素（LH）]、再粘连发生情况，以及安全性。
结果 试验组和对照组分别入组48例和44例。治疗2个月经周期后，试验组和对照组的总有效率分别为95.83%（46例/48例）和81.82%（36例/44例），在统计学上差异有统计学意义（P<0.05）。治疗2个月经周期后，试验组和对照组子宫内膜厚度分别为（7.88±1.02）和（7.12±0.86）mm，子宫内膜体积分别为（3.02±0.97）和（2.57±0.73）cm3，VI分别为1.21±0.59和0.88±0.57，FI为29.87±5.12和27.56±4.63，VFI分别为1.12±0.43和0.83±0.36，E2分别为（239.62±25.47）和（168.91±20.12）pmol·L-1，FSH分别为（8.94±2.02）和（10.63±2.14）U·L-1，LH分别为（13.38±2.16）和（15.27±2.59）U·L-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要有乳房胀痛和消化道不适，对照组的药物不良反应主要有乳房胀痛、消化道不适和头痛。试验组和对照组的药物不良反应总发生率分别为14.58%（7例/48例）和11.36%（5例/44例），在统计学上差异无统计学意义（P>0.05）。试验组和对照组的再粘连发生率分别为6.25%（3例/48例）和20.45%（9例/44例），在统计学上差异有统计学意义（P<0.05）。
结论 IUA术后采用地屈孕酮联合戊酸雌二醇预防宫腔再粘连的临床疗效显著，可有效改善患者子宫内膜容受性、性激素水平，用药安全。
, authors=年妍
1a, 仲佳雯
2, 李晓荣
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年妍（1984-），女，硕士，副主任医师，主要从事宫腔镜及宫内疾病临床诊疗方面的工作
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