Article(id=1291404354968346973, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1721923200000, receivedDateStr=2024-07-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824391356, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824391356, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824391356, creator=13701087609, updateTime=1785824391356, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=522, endPage=526, ext={EN=ArticleExt(id=1291404356583154014, articleId=1291404354968346973, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Protective effect of hedysarum polybotrys polysacchcaide on the intestinal mucosal barrier of rats with spleen deficiency DGP, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the protective effect of hedysarum polybotrys polysacchcaide (HPS) on intestinal mucosal barrier in rats with splenic deficiency type diabetic gastroparesis.
Methods The rat model of spleen deficiency DGP was prepared by multifactorial combined with low-dose intraperitoneal injection of Stretocin. The rats were randomly divided into blank group (pure water gavage), model group (pure water gavage), positive control group (0.09 g·kg-1 metformin hydrochloride sustained-release tablet) and experimental-H,-M,-L groups (0.20, 0.10, 0.05 g·kg-1 HPS), each group was administered by gavage once a day for 8 W. Measured blood glucose, diamine oxidase (DAO), lipopolysaccharides (LPS), D-lactate contents (D-LA) in serum by enzyme linked immunosorbent assay method; Claudin-1, Occludin, Zonula Occluden-1 (ZO-1) mRNA and protein expressions in lleal tissue were detected by reverse transcription-polymerase chain reaction and Western blot.
Results The blood glucose in the blank group, model group, positive control group, experimental-H,-M,-L groups were (5.04±0.40), (30.71±1.21), (18.63±6.72) and (19.90±3.30)mmol·L-1; the DAO were (49.56±6.13), (192.19±24.40), (130.63±19.90) and (120.24±17.53) pg·mL-1; the LPS were (41.11±4.56), (99.67±6.63), (64.51±8.59) and (63.07±4.89) ng·L-1; the D-LA were (506.45±52.22), (1 826.49±224.17), (1 166.47±121.78) and (1 344.82±130.65) μg·L-1; the relative expression levels of Claudin-1 mRNA were 1.03±0.32, 0.25±0.12, 0.94±0.40 and 0.71±0.21; the relative expression levels of Occludin mRNA were 1.07±0.48, 0.26±0.06, 1.23±0.42 and 0.99±0.47; the relative expression levels of ZO-1 mRNA were 1.00±0.13, 0.43±0.18, 0.85±0.07 and 0.69±0.08; the relative expression levels of Claudin-1 protein were 1.00±0.00, 0.21±0.19, 0.56±0.31 and 0.87±0.31; the relative expression levels of Occludin protein were 1.01±0.27, 0.38±0.11, 0.88±0.10 and 0.85±0.18; the relative expression levels of ZO-1 protein were 1.00±0.14, 0.43±0.04, 0.77±0.02 and 0.67±0.16. Compared with the the blank group, the above indexes in the model group had statistical significance (P<0.01, P<0.05); compared with the model group, the above indexes in the experimental-H had statistical significance (P<0.01, P<0.05).
Conclusion HPS can reduce intestinal mucosal injury and maintain the integrity of the intestinal mucosal barrier in spleen deficiency DGP rats.
, authors=Zhao-hui WEI, Sheng-fang WAN, Rong-ke LI, Qian GUO, Xin-xin MA, authorsList=Zhao-hui WEI, Sheng-fang WAN, Rong-ke LI, Qian GUO, Xin-xin MA, authorCompany=null, correspAuthors=Sheng-fang WAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404357006778719, articleId=1291404354968346973, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=红芪多糖对脾虚型DGP大鼠肠道黏膜屏障的保护作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨红芪多糖（HPS）对脾虚型糖尿病胃轻瘫（DGP）大鼠肠黏膜屏障的保护作用。
方法 用多因素联合小剂量腹腔多次注射链脲佐菌素（STZ）法制备脾虚型DGP大鼠模型。将大鼠随机分为空白组（纯水灌胃）、模型组（纯水灌胃）、阳性对照组（0.09 g·kg-1盐酸二甲双胍缓释片）和高、中、低剂量实验组（0.20、0.10、0.05 g·kg-1 HPS），各组均每天灌胃给药1次，连续8周。检测血糖，用酶联免疫吸附实验（ELISA）法检测血清中二胺氧化酶（DAO）、脂多糖（LPS）、D-乳酸（D-LA）含量，用逆转录聚合酶链反应（RT-PCR）和蛋白质印迹法检测回肠组织中闭锁蛋白1（Claudin-1）、闭合蛋白（Occludin）、连接复合物蛋白1（ZO-1）mRNA及蛋白相对表达水平。
结果 空白组、模型组、阳性对照组和高剂量实验组的血糖分别为（5.04±0.40）、（30.71±1.21）、（18.63±6.72）和（19.90±3.30）mmol·L-1，血清DAO分别为（49.56±6.13）、（192.19±24.40）、（130.63±19.90）和（120.24±17.53）pg·mL-1，LPS分别为（41.11±4.56）、（99.67±6.63）、（64.51±8.59）和（63.07±4.89）ng·L-1，D-LA分别为（506.45±52.22）、（1 826.49±224.17）、（1 166.47±121.78）和（1 344.82±130.65）μg·L-1，Claudin-1 mRNA相对表达水平分别为1.03±0.32、0.25±0.12、0.94±0.40和0.71±0.21，Occludin mRNA相对表达水平分别为1.07±0.48、0.26±0.06、1.23±0.42、0.99±0.47，ZO-1 mRNA相对表达水平为1.00±0.13、0.43±0.18、0.85±0.07和0.69±0.08，Claudin-1蛋白相对表达水平分别为1.00±0.00、0.21±0.19、0.56±0.31和0.87±0.31，Occludin蛋白相对表达水平分别为1.01±0.27、0.38±0.11、0.88±0.10和0.85±0.18，ZO-1蛋白相对表达水平分别为1.00±0.14、0.43±0.04、0.77±0.02和0.67±0.16。模型组的上述指标与空白组比较，在统计学上差异均有统计学意义（P<0.01，P<0.05）；高剂量实验组的上述指标与模型组比较，在统计学上差异均有统计学意义（P<0.01，P<0.05）。
结论 HPS可降低脾虚型DGP大鼠肠黏膜损伤，维持脾虚型DGP大鼠肠道黏膜屏障完整性。
, authors=魏昭晖, 万生芳, 李荣科, 郭倩, 马欣欣, authorsList=魏昭晖, 万生芳, 李荣科, 郭倩, 马欣欣, authorCompany=null, correspAuthors=万生芳, authorNote=
魏昭晖（1994-），女，博士研究生，主要从事中医药防治糖尿病方面的研究
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