Article(id=1291404330444255519, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1721577600000, receivedDateStr=2024-07-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824385510, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824385510, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824385510, creator=13701087609, updateTime=1785824385510, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=552, endPage=555, ext={EN=ArticleExt(id=1291404330632999200, articleId=1291404330444255519, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Determination of epinephrine in epinephrine hydrochloride injection by high performance liquid chromatography, columnId=1246531413395263850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Research Method, runingTitle=null, highlight=null, articleAbstract=
Objective To develop a high performance liquid chromatographic method for determination of epinephrine in epinephrine hydrochloride injection.
Methods The separation was carried out on a Waters XBridge C18 column (150.0 mm×4.6 mm, 5 μm) with isocratic elution . The mobile phase consisted of 5.0 g·L-1 potassium dihydrogen phosphate and 2.6 g·L-1 octanesulfonic acid sodium solution (adjusting pH to 3.7 by phosphoric acid) -acetonitrile (85∶15) with the flow rate of 1.0 mL·min-1, the column temperature of 40 ℃, the detection wavelength of 280 nm and the injection volume of 10 μL. The specificity, standard curve and lower limit of quantitation (LLOQ), system suitability, stability, precision and recovery were investigated.
Results The calibration curve of epinephrine was linear in the range of 2.09 - 83.66 μg·mL-1. The standard curve of epinephrine was y=8.74×103x-2.72×103 (r=1.000 0). The LLOQ was 2.09 μg·mL-1. The system applicability was proved to be good since the relative standard deviation (RSD) of the main peak area was 0.19% and the RSD of retention time was 0.18%. The RSD of the test solution at high, medium and low concentrations was less than 0.5%, and the average recovery rate was 105.09%-107.86%. The test solution was stable within 4 h.
Conclusion The method validation proveded that the proposed method was stable, recovery, precise and specificity, which could be used for the measurement of epinephrine in epinephrine hydrochloride injection administration preparation.
, authors=Ling-yan HE, Chen-qian WANG, Ruo-qi WANG, Hui YUAN, Yu-hao WANG, Jian-hua CHEN, Jie GAO, Xiu-jun QIN, Jian-guo LI, authorsList=Ling-yan HE, Chen-qian WANG, Ruo-qi WANG, Hui YUAN, Yu-hao WANG, Jian-hua CHEN, Jie GAO, Xiu-jun QIN, Jian-guo LI, authorCompany=null, correspAuthors=Jian-guo LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404330930794785, articleId=1291404330444255519, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=用高效液相色谱法测定肾上腺素注射液给药制剂中肾上腺素的含量, columnId=1246531413600784769, journalTitle=中国临床药理学杂志, columnName=研究方法, runingTitle=null, highlight=null, articleAbstract=
目的 建立一种高效液相色谱法测定肾上腺素注射液给药制剂中肾上腺素的浓度。
方法 用Waters XBridge C18（150.0 mm×4.6 mm，5 μm）色谱柱等度洗脱，以离子对溶液（取磷酸二氢钾5.0 g和辛烷磺酸钠2.6 g，溶于水1 000 mL中，用磷酸调节pH值至3.7）-乙腈（85∶15）为流动相，流速为1.0 mL·min-1，柱温为40 ℃，检测波长为280 nm，进样量为10 μL。考察该方法的专属性、标准曲线与定量下限、系统适用性、稳定性、精密度与回收率。
结果 肾上腺素在2.09~83.66 μg·mL-1内，线性关系良好，标准曲线方程为y=8.74×103x-2.72×103（r=1.000 0），定量下限为2.09 μg·mL-1。主峰峰面积相对标准偏差（RSD）为0.19%，保留时间RSD为0.18%，系统适用性良好；高、中、低3个质量浓度的供试品溶液测定结果的RSD均小于0.5%，平均回收率为105.09%~107.86%。肾上腺素注射液供试品溶液在4 h内稳定。
结论 本方法具有良好的稳定性、回收率、精密度和专属性，适用于测定肾上腺素注射液给药制剂中肾上腺素的含量。
, authors=何灵艳, 王晨倩, 王若琪, 袁慧, 王雨豪, 陈建华, 高洁, 秦秀军, 李建国, authorsList=何灵艳, 王晨倩, 王若琪, 袁慧, 王雨豪, 陈建华, 高洁, 秦秀军, 李建国, authorCompany=null, correspAuthors=李建国, authorNote=
何灵艳（1996-），女，实习研究员，主要从事新药安全性评价的相关研究
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