Article(id=1291404321762038480, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.029, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1716134400000, receivedDateStr=2024-05-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824383439, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824383439, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824383439, creator=13701087609, updateTime=1785824383439, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=591, endPage=595, ext={EN=ArticleExt(id=1291404321946587857, articleId=1291404321762038480, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical research status of ciprofol, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Ciprofol is a type of innovative drug independently developed in China and with global independent intellectual property rights. It is a short-acting intravenous sedative based on the structural modification of propofol. It has the advantages of fast onset, fast recovery, high titer, good selectivity, low accumulation, stable respiratory circulation, and few adverse reactions, providing a better choice for clinical stable sedation and anesthesia, and has good clinical application potential. A series of clinical studies have evaluated the sedative effects of ciprofol in various procedures and settings, demonstrating its application in endoscopic sedation, general anesthesia, and sedation during intensive care. This paper reviewed the mechanism of action, pharmacokinetics and pharmacokinetic properties of ciprofol, and the progress of clinical application research, and evaluated the effectiveness and safety of ciprofol by synthesizing relevant clinical trial data.

, authors=Yu JIANG^{1, 2}, Wen-long HOU², Jian-long DU¹, You-ming ZONG², authorsList=Yu JIANG, Wen-long HOU, Jian-long DU, You-ming ZONG, authorCompany=null, correspAuthors=You-ming ZONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404322298909394, articleId=1291404321762038480, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=环泊酚的临床研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

环泊酚是我国自主研发且具有全球自主知识产权的一类创新药，是基于丙泊酚结构修饰的短效麻醉镇静药，具有起效快、苏醒快、效价高、选择性好、蓄积低、呼吸循环稳定、药物不良反应少等优势，为临床平稳镇静麻醉提供更好的选择，具有良好的临床应用潜力。一系列的临床研究评估了环泊酚在不同程序和环境下的镇静作用，证明其可应用于内镜诊疗、全身麻醉、重症监护期间的镇静。本文综述了环泊酚的作用机制、药代动力学和药效学特性、临床应用研究进展等，通过综合相关临床试验数据，评价环泊酚的有效性和安全性。

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江宇（1998-），男，医师，主要从事瑞马唑仑靶控输注的相关研究

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江宇（1998-），男，医师，主要从事瑞马唑仑靶控输注的相关研究

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