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Article(id=1291404312664597462, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1723651200000, receivedDateStr=2024-08-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824381270, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824381270, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824381270, creator=13701087609, updateTime=1785824381270, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=502, endPage=506, ext={EN=ArticleExt(id=1291404312861729751, articleId=1291404312664597462, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Mechanism of Tanshinone ⅡA on the inhibition of myocardial infarction based on NRF2/NLRP3/pyroptosis axis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To explore the underlying mechanism of TanshinoneⅡA (TanⅡA) exerted in myocardial infarction (MI) through nuclear factor E2-related factor 2 (NRF2)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3)/pyroptosis axis.

Methods

SD rats were randomly divided into sham operation group [only exposed the heart without left anterior descending (LAD) ligation], model group (LAD ligation) and experimental group (LAD ligation and 10 mg·kg-1 TanⅡA). 2,3,5-Triphenyte-trazoliumchloride (TTC) staining was used to detect the area of infarction; Western blot was utilized to investigate the expression level of NRF2, NLRP3 and gasdermin D (GSDMD) in myocardial tissue. The H9c2 cells were divided into blank group (normal culture), model group [oxygen-glucose deprivation (OGD) culture], control group (normal culture and 40 μmol·L-1 TanⅡA) and combined group (OGD culture and 40 μmol·L-1 TanⅡA). Western blot was utilized to investigate the expression level of NRF2, GSDMD in cardiomyocyte. Creatine kinase MB (CK-MB) in cell culture supernatant were detected by automatic biochemical analyzer.

Results

The proportion of myocardial infarction area in the sham operation group, model group and experimental group were 0, (58.64±13.41)% and (41.69±8.73)%, respectively; the relative expression of NLRP3 protein were 1.01±0.10, 2.12±0.26 and 1.48±0.11, respectively; the relative expression of GSDMD protein were 1.03±0.17, 2.22±0.20 and 1.40±0.17, respectively; the relative expression of NRF2 protein were 1.12±0.29, 0.51±0.02 and 0.96±0.10, respectively; the indicators of the model group compared with the sham operation group, and the indicators of the experimental group were compared with the model group, the differences were statistically significant (all P<0.05). The CK-MB in blank group, model group, control group and combined group were (54.30±19.24), (208.60±38.19), (46.76±13.63) and (126.10±42.87) U·L-1, respectively; the relative expression of NRF2 protein were 1.37±0.14, 0.44±0.08, 1.34±0.17 and 0.79±0.11, respectively; the relative expression of GSDMD protein were 0.95±0.26, 1.97±0.17, 1.04±0.20 and 1.16±0.16, respectively. The indicators of the model group compared with the blank group, and the indicators of the combined group were compared with the model group, the differences were statistically significant (all P<0.05).

Conclusion

TanⅡA can alleviate myocardial infarction-induced myocardial injury through regulation NRF2/NLRP3/pyroptosis axis.

, authors=Na YI1, Yuan TIAN2, Li-li YUAN2, authorsList=Na YI, Yuan TIAN, Li-li YUAN, authorCompany=null, correspAuthors=Li-li YUAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404313155331032, articleId=1291404312664597462, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于NRF2/NLRP3/焦亡轴探讨丹参酮ⅡA抑制心肌梗死的作用机制, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

探讨丹参酮ⅡA（TanⅡA）通过核因子E2相关因子2（NRF2）/NOD样受体家族蛋白3（NLRP3）/焦亡信号通路抑制大鼠心肌梗死的作用机制。

方法

将SD大鼠随机分为假手术组（只暴露心脏，不结扎）、模型组（结扎左冠状动脉前降支）、实验组（结扎左冠状动脉前降支后尾静脉注射10 mg·kg-1 TanⅡA）。用2，3，5—氯化三苯基四氮唑（TTC）染色法检测心肌梗死情况，用蛋白质印迹法检测心肌组织NRF2、NLRP3和焦孔素D（GSDMD）蛋白相对表达水平。将H9c2细胞分为空白组（常规培养）、模型组（糖氧剥夺培养）、对照组（40 μmol·L-1 TanⅡA）、联合组（糖氧剥夺培养+40 μmol·L-1 TanⅡA）。用蛋白质印迹法检测H9c2细胞NRF2、GSDMD蛋白相对表达水平，用全自动生化检测细胞上清肌酸激酶-MB（CK-MB）含量。

结果

假手术组、模型组和实验组的心肌组织梗死区域占比分别为0、（58.64±13.41）%和（41.69±8.73）%，NLRP3蛋白相对表达水平分别为1.01±0.10、2.12±0.26和1.48±0.11，GSDMD蛋白相对表达水平分别为1.03±0.17、2.22±0.20和1.40±0.17，NRF2蛋白相对表达水平分别为1.12±0.29、0.51±0.02和0.96±0.10。模型组的上述指标与假手术组比较，实验组的上述指标与模型组比较，在统计学上差异均有统计学意义（均P<0.05）。空白组、模型组、对照组和联合组的CK-MB分别为（54.30±19.24）、（208.60±38.19）、（46.76±13.63）和（126.10±42.87）U·L-1，NRF2蛋白相对表达水平分别为1.37±0.14、0.44±0.08、1.34±0.17和0.79±0.11，GSDMD蛋白相对表达分别为0.95±0.26、1.97±0.17、1.04±0.20和1.16±0.16。模型组的上述指标与空白组比较，联合组上述指标与模型组比较，在统计学上差异均有统计学意义（均P<0.05）。

结论

TanⅡA通过调控NRF2/NLRP3/焦亡轴抑制心肌梗死。

, authors=易娜1, 田源2, 袁李礼2, authorsList=易娜, 田源, 袁李礼, authorCompany=null, correspAuthors=袁李礼, authorNote=

易娜（1983-），女，副主任医师，主要从事心肌损伤方面的研究

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袁李礼，副主任医师 Tel: （0731）85230017 E-mail:
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基于NRF2/NLRP3/焦亡轴探讨丹参酮ⅡA抑制心肌梗死的作用机制
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易娜 1 , 田源 2 , 袁李礼 2
中国临床药理学杂志 | 临床与基础桥接研究 2025,41(4): 502-506
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中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (4) : 502 -506
基于NRF2/NLRP3/焦亡轴探讨丹参酮ⅡA抑制心肌梗死的作用机制
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易娜1, 田源2, 袁李礼2
作者信息
  • 1.长沙市第四医院 心内科，湖南 长沙 410006
  • 2.湖南省第二人民医院（湖南省脑科医院） 心内科，湖南 长沙 410007
通讯作者:
袁李礼，副主任医师 Tel: （0731）85230017 E-mail:
作者简介:

易娜（1983-），女，副主任医师，主要从事心肌损伤方面的研究

Mechanism of Tanshinone ⅡA on the inhibition of myocardial infarction based on NRF2/NLRP3/pyroptosis axis
Na YI1, Yuan TIAN2, Li-li YUAN2
Affiliations
  • 1.Department of Cardiology, the Fourth Hospital of Changsha, Changsha 410006, Hunan Province, China
  • 2.Department of Cardiology, The Second People’s Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha 410007, Hunan Province, China
出版时间: 2025-02-28 doi: 10.13699/j.cnki.1001-6821.2025.04.011
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摘要
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目的

探讨丹参酮ⅡA（TanⅡA）通过核因子E2相关因子2（NRF2）/NOD样受体家族蛋白3（NLRP3）/焦亡信号通路抑制大鼠心肌梗死的作用机制。

方法

将SD大鼠随机分为假手术组（只暴露心脏，不结扎）、模型组（结扎左冠状动脉前降支）、实验组（结扎左冠状动脉前降支后尾静脉注射10 mg·kg-1 TanⅡA）。用2，3，5—氯化三苯基四氮唑（TTC）染色法检测心肌梗死情况，用蛋白质印迹法检测心肌组织NRF2、NLRP3和焦孔素D（GSDMD）蛋白相对表达水平。将H9c2细胞分为空白组（常规培养）、模型组（糖氧剥夺培养）、对照组（40 μmol·L-1 TanⅡA）、联合组（糖氧剥夺培养+40 μmol·L-1 TanⅡA）。用蛋白质印迹法检测H9c2细胞NRF2、GSDMD蛋白相对表达水平，用全自动生化检测细胞上清肌酸激酶-MB（CK-MB）含量。

结果

假手术组、模型组和实验组的心肌组织梗死区域占比分别为0、（58.64±13.41）%和（41.69±8.73）%，NLRP3蛋白相对表达水平分别为1.01±0.10、2.12±0.26和1.48±0.11，GSDMD蛋白相对表达水平分别为1.03±0.17、2.22±0.20和1.40±0.17，NRF2蛋白相对表达水平分别为1.12±0.29、0.51±0.02和0.96±0.10。模型组的上述指标与假手术组比较，实验组的上述指标与模型组比较，在统计学上差异均有统计学意义（均P<0.05）。空白组、模型组、对照组和联合组的CK-MB分别为（54.30±19.24）、（208.60±38.19）、（46.76±13.63）和（126.10±42.87）U·L-1，NRF2蛋白相对表达水平分别为1.37±0.14、0.44±0.08、1.34±0.17和0.79±0.11，GSDMD蛋白相对表达分别为0.95±0.26、1.97±0.17、1.04±0.20和1.16±0.16。模型组的上述指标与空白组比较，联合组上述指标与模型组比较，在统计学上差异均有统计学意义（均P<0.05）。

结论

TanⅡA通过调控NRF2/NLRP3/焦亡轴抑制心肌梗死。

丹参酮ⅡA  /  核因子E2相关因子2  /  NOD样受体家族蛋白3  /  心肌梗死  /  焦亡
Objective

To explore the underlying mechanism of TanshinoneⅡA (TanⅡA) exerted in myocardial infarction (MI) through nuclear factor E2-related factor 2 (NRF2)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3)/pyroptosis axis.

Methods

SD rats were randomly divided into sham operation group [only exposed the heart without left anterior descending (LAD) ligation], model group (LAD ligation) and experimental group (LAD ligation and 10 mg·kg-1 TanⅡA). 2,3,5-Triphenyte-trazoliumchloride (TTC) staining was used to detect the area of infarction; Western blot was utilized to investigate the expression level of NRF2, NLRP3 and gasdermin D (GSDMD) in myocardial tissue. The H9c2 cells were divided into blank group (normal culture), model group [oxygen-glucose deprivation (OGD) culture], control group (normal culture and 40 μmol·L-1 TanⅡA) and combined group (OGD culture and 40 μmol·L-1 TanⅡA). Western blot was utilized to investigate the expression level of NRF2, GSDMD in cardiomyocyte. Creatine kinase MB (CK-MB) in cell culture supernatant were detected by automatic biochemical analyzer.

Results

The proportion of myocardial infarction area in the sham operation group, model group and experimental group were 0, (58.64±13.41)% and (41.69±8.73)%, respectively; the relative expression of NLRP3 protein were 1.01±0.10, 2.12±0.26 and 1.48±0.11, respectively; the relative expression of GSDMD protein were 1.03±0.17, 2.22±0.20 and 1.40±0.17, respectively; the relative expression of NRF2 protein were 1.12±0.29, 0.51±0.02 and 0.96±0.10, respectively; the indicators of the model group compared with the sham operation group, and the indicators of the experimental group were compared with the model group, the differences were statistically significant (all P<0.05). The CK-MB in blank group, model group, control group and combined group were (54.30±19.24), (208.60±38.19), (46.76±13.63) and (126.10±42.87) U·L-1, respectively; the relative expression of NRF2 protein were 1.37±0.14, 0.44±0.08, 1.34±0.17 and 0.79±0.11, respectively; the relative expression of GSDMD protein were 0.95±0.26, 1.97±0.17, 1.04±0.20 and 1.16±0.16, respectively. The indicators of the model group compared with the blank group, and the indicators of the combined group were compared with the model group, the differences were statistically significant (all P<0.05).

Conclusion

TanⅡA can alleviate myocardial infarction-induced myocardial injury through regulation NRF2/NLRP3/pyroptosis axis.

TanshinoneⅡA  /  nuclear factor E2-related factor 2  /  NOD-like receptor thermal protein domain associated protein 3  /  myocardial infarction  /  pyroptosis
易娜, 田源, 袁李礼. 基于NRF2/NLRP3/焦亡轴探讨丹参酮ⅡA抑制心肌梗死的作用机制. 中国临床药理学杂志, 2025 , 41 (4) : 502 -506 . DOI: 10.13699/j.cnki.1001-6821.2025.04.011
Na YI, Yuan TIAN, Li-li YUAN. Mechanism of Tanshinone ⅡA on the inhibition of myocardial infarction based on NRF2/NLRP3/pyroptosis axis[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (4) : 502 -506 . DOI: 10.13699/j.cnki.1001-6821.2025.04.011
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  • 湖南省自然科学基金资助项目(2022JJ80101; 2022JJ80062)
  • 湖南省卫健委科研基金资助项目(202203012960; 202103010510)
  • 湖南省教育厅科研基金资助项目(21B0088)
  • 湖南省中医药科技基金资助项目(D2022024)
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doi: 10.13699/j.cnki.1001-6821.2025.04.011
  • 接收时间：2024-08-15
  • 首发时间：2026-08-04
  • 出版时间：2025-02-28
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  • 收稿日期：2024-08-15
基金
湖南省自然科学基金资助项目(2022JJ80101; 2022JJ80062)
湖南省卫健委科研基金资助项目(202203012960; 202103010510)
湖南省教育厅科研基金资助项目(21B0088)
湖南省中医药科技基金资助项目(D2022024)
作者信息
    1.长沙市第四医院 心内科，湖南 长沙 410006
    2.湖南省第二人民医院（湖南省脑科医院） 心内科，湖南 长沙 410007

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袁李礼，副主任医师 Tel: （0731）85230017 E-mail:
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
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