Article(id=1291404308268970026, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1723651200000, receivedDateStr=2024-08-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824380222, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824380222, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824380222, creator=13701087609, updateTime=1785824380222, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=497, endPage=501, ext={EN=ArticleExt(id=1291404308478685227, articleId=1291404308268970026, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration on radiation heart disease in rats, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the intervention effects of Radix Angelica Sinensis and Radix Hedysari ultrafiltration (RAS-RH) on the NOD-like receptor thermal protein domain associated protein 3/cysteinyl aspartate specific proteinase-1/gasdermin D (NLRP3/Caspase-1/GSDMD) signaling pathway and radiation-induced heart disease (RIHD).
Methods A model was constructed using a single whole-body X-ray irradiation at a dose of 8 Gy. SPF-grade male Wistar rats were randomly divided into the normal group, the model group (X-ray 8 Gy), the experimental-L group (X-ray 8 Gy+25 mg·kg-1·d-1 RAS-RH by gavage) and the experimental-H group (X-ray 8 Gy+50 mg·kg-1·d-1 RAS-RH by gavage), with ten rats in each group. 2 h after the last administration, cardiac function was evaluated using echocardiography; serum levels of inflammatory factors, including interleukin-18 (IL-18), IL-1β and tumor necrosis factor-alpha (TNF-α) were measured using enzyme-linked immunosorbent; relative protein expression levels of NLRP3, Caspase-1, GSDMD, IL-18 and IL-1β in myocardial tissue were detected using Western blotting.
Results The left ventricular ejection fraction (LVEF) in experimental-L group, experimental-H group, normal group and model group were (66.61±1.04)%, (71.89±0.69)%, (81.45±1.34)% and (47.62±1.67)%; the serum levels of IL-18 were (171.21±3.92), (145.60±3.37), (125.51±2.94) and (201.80±4.05) ng·mL-1; the IL-1β levels were (43.03±0.68), (41.12±1.01), (36.12±0.98) and (51.19±0.85) ng·mL-1; the TNF-α levels were (484.96±3.35), (441.24±3.94), (381.32±4.16) and (566.51±4.98) ng·mL-1; the relative expression levels of NLRP3 protein in myocardial tissue were 0.54±0.02, 0.34±0.02, 0.20±0.02 and 0.75±0.03; the relative expression levels of Caspase-1 protein were 0.52±0.02, 0.44±0.02, 0.36±0.02 and 0.65±0.03; the relative expression levels of GSDMD-NT protein were 0.53±0.02, 0.42±0.01, 0.33±0.02 and 0.73±0.03; the relative expression levels of IL-18 protein were 0.50±0.02, 0.42±0.01, 0.13±0.01 and 0.63±0.02; the relative expression levels of IL-1β protein were 0.59±0.02, 0.42±0.02, 0.27±0.02 and 0.79±0.03, respectively. The indicators in the model group were significantly different compared to the normal group, and the indicators in the experimental-L and experimental-H groups were significantly different from the model group, with statistical significance (all P<0.05).
Conclusion RAS-RH may improve RIHD by regulating the NLRP3/Caspase-1/GSDMD signaling pathway.
, authors=Xiang GAO
1, 2, Guo-ci LU
1, Chun-zhen REN
1, Xin-fang LÜ
1, Qi-lin CHEN
1, Xue WU
1, Xiao-dong ZHI
1, Chun-ling WANG
1, Ying-dong LI
1, authorsList=Xiang GAO, Guo-ci LU, Chun-zhen REN, Xin-fang LÜ, Qi-lin CHEN, Xue WU, Xiao-dong ZHI, Chun-ling WANG, Ying-dong LI, authorCompany=null, correspAuthors=Ying-dong LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404308780675116, articleId=1291404308268970026, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=当归红芪超滤物对放射性心脏病大鼠的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察当归红芪超滤物（RAS-RH）对NOD样受体热蛋白结构域相关蛋白3/半胱氨酸天冬氨酸蛋白酶-1/消皮素D（NLRP3/Caspase-1/GSDMD）信号通路及放射性心脏病（RIHD）的干预效应。
方法 用X射线8 Gy剂量单次全身照射构建模型。将SPF级雄性Wistar大鼠随机分为正常组、模型组（X射线8 Gy）和低剂量实验组（X射线8 Gy+25 mg·kg-1·d-1 RAS-RH灌胃）、高剂量实验组（X射线8 Gy+50 mg·kg-1·d-1 RAS-RH灌胃），每组各10只，在末次给药后2 h末。用心脏彩超评价大鼠心功能，用酶联免疫吸附试验检测血清中炎症因子白细胞介素（IL）-18、IL-1β和肿瘤坏死因子-α（TNF-α）的表达，用蛋白质印迹法检测大鼠心肌组织NLRP3、Caspase-1、GSDMD、IL-18和IL-1β蛋白相对表达水平。
结果 低、高剂量实验组和正常组、模型组的左心室射血分数（LVEF）分别为（66.61±1.04）%、（71.89±0.69）%、（81.45±1.34）%和（47.62±1.67）%，血清IL-18水平分别为（171.21±3.92）、（145.60±3.37）、（125.51±2.94）和（201.80±4.05）ng·mL-1，IL-1β水平分别为（43.03±0.68）、（41.12±1.01）、（36.12±0.98）和（51.19±0.85）ng·mL-1，TNF-α水平分别为（484.96±3.35）、（441.24±3.94）、（381.32±4.16）和（566.51±4.98）ng·mL-1，心肌组织NLRP3蛋白相对表达水平分别为0.54±0.02、0.34±0.02、0.20±0.02和0.75±0.03，Caspase-1蛋白相对表达水平分别为0.52±0.02、0.44±0.02、0.36±0.02和0.65±0.03，GSDMD-蛋白N端（GSDMD-NT）蛋白相对表达水平分别为0.53±0.02、0.42±0.01、0.33±0.02和0.73±0.03，IL-18蛋白相对表达水平分别为0.50±0.02、0.42±0.01、0.13±0.01和0.63±0.02，IL-1β蛋白相对表达水平分别为0.59±0.02、0.42±0.02、0.27±0.02和0.79±0.03。模型组的上述指标与正常组比较，低、高剂量实验组的上述指标与模型组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 RAS-RH可能通过调控NLRP3/Caspase-1/GSDMD信号通路对RIHD具有改善作用。
, authors=高翔
1, 2, 卢国赐
1, 任春贞
1, 吕欣芳
1, 陈其林
1, 吴雪
1, 支晓东
1, 王春玲
1, 李应东
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高翔（1980-），男，博士研究生，主要从事中西医结合防治心血管疾病的相关研究
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