Article(id=1291404300878603125, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1727625600000, receivedDateStr=2024-09-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824378461, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824378461, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824378461, creator=13701087609, updateTime=1785824378461, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=492, endPage=496, ext={EN=ArticleExt(id=1291404301050569590, articleId=1291404300878603125, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of ulinastatin on epithelial-mesenchymal transition of bladder cancer cells based on Wnt pathway, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect of ulinastatin on epithelial-mesenchymal transition (EMT) of bladder cancer T24 cells.
Methods Bladder cancer T24 cells were randomly divided into blank, control, experimental, combined groups. The cells in the blank group were cultured normally; and the cells in the control group were treated with RPMI-1640 medium containing 0.75 μmol·L-1 KYA1797K; the cells in the experimental group were treated with RPMI-1640 medium containing 5.00 μmol·L-1 ulinastatin and the cells in the combined group were treated with RPMI-1640 medium containing 5.00 μmol·L-1 ulinastatin and 0.75 μmol·L-1 KYA1797K. The treatment time was 48 hours. The cell viability was detected by methyl thiazolyl tetrazolium (MTT) assay. Transwell assay was used to detect the invasion and migration ability of cells. The protein expression levels of epithelial-mesenchymal transition related proteins, wingless-type MMTV integration site family 3α (Wnt3α) and β-catenin were detected by Western blotting.
Results The survival rates of the blank group, control group, experimental group and combined group were (100.00±0.00)%, (73.28±6.37)%, (76.98±5.82)% and (40.36±3.21)%, respectively; the numbers of invasive cells were 66.83±8.18, 33.33±3.27, 38.67±4.32 and 11.33±1.21, respectively; the migration number were 79.33±6.38, 53.00±6.26, 52.33±3.14 and 28.33±5.28, respectively; the relative expression levels of E-cadherin protein were 0.23±0.08, 0.51±0.02, 0.58±0.05 and 0.82±0.03, respectively; the relative expression levels of Vimentin protein were 0.78±0.03, 0.55±0.02, 0.58±0.06 and 0.27±0.06, respectively; the relative expression levels of N-cadherin were 0.83±0.08, 0.59±0.02, 0.62±0.02 and 0.31±0.09, respectively; the relative expression levels of Wnt3α protein were 0.85±0.09, 0.28±0.13, 0.29±0.05 and 0.12±0.01, respectively; the relative expression levels of β-catenin were 0.81±0.05, 0.25±0.07, 0.22±0.03 and 0.08±0.02, respectively. The above indexes in the control group and experimental group were significantly different from those in the blank group and combined group (all P<0.05).
Conclusion Ulinastatin can inhibit the epithelial-mesenchymal transition of bladder cancer T24 cells, and its mechanism may be related to the inhibition of Wnt signaling pathway.
, authors=Fen LIU
1a, Xiao-shi LI
1b, Hui-ming ZHANG
1b, authorsList=Fen LIU, Xiao-shi LI, Hui-ming ZHANG, authorCompany=null, correspAuthors=Hui-ming ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404303017698167, articleId=1291404300878603125, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于Wnt通路探讨乌司他丁对膀胱癌细胞上皮间质转化的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究乌司他丁对膀胱癌T24细胞上皮间质转化的影响。
方法 将膀胱癌T24细胞随机分为空白组、对照组、实验组和联合组。空白组给予正常培养，对照组给予含0.75 μmol·L-1 KYA1797K的RPMI-1640培养基进行处理；实验组给予含5.00 μmol·L-1乌司他丁的RPMI-1640培养基进行处理，联合组给予含5.00 μmol·L-1乌司他丁与0.75 μmol·L-1 KYA1797K的RPMI-1640培养基进行处理。干预48 h后，用四甲基偶氮唑蓝法检测细胞的存活率，用Transwell实验法检测细胞的侵袭与迁移能力，用蛋白质印迹法检测上皮间质转化相关蛋白、整合位点家族成员3α（Wnt3α）和β连环蛋白（β-catenin）的表达水平。
结果 空白组、对照组、实验组和联合组的细胞存活率分别为（100.00±0.00）%、（73.28±6.37）%、（76.98±5.82）%和（40.36±3.21）%，侵袭细胞数量分别为（66.83±8.18）、（33.33±3.27）、（38.67±4.32）和（11.33±1.21）个，细胞迁移数分别为（79.33±6.38）、（53.00±6.26）、（52.33±3.14）和（28.33±5.28）个，E-钙黏蛋白相对表达水平分别为0.23±0.08、0.51±0.02、0.58±0.05和0.82±0.03，波形蛋白相对表达水平分别为0.78±0.03、0.55±0.02、0.58±0.06和0.27±0.06，N-钙黏蛋白相对表达水平分别为0.83±0.08、0.59±0.02、0.62±0.02和0.31±0.09，Wnt3α蛋白相对表达水平分别为0.85±0.09、0.28±0.13、0.29±0.05和0.12±0.01，β-catenin蛋白相对表达水平分别为0.81±0.05、0.25±0.07、0.22±0.03和0.08±0.02。实验组、对照组的上述指标分别与空白组、联合组相比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 乌司他丁能够抑制膀胱癌T24细胞的上皮间质转化过程，其作用机制可能与抑制Wnt信号通路相关。
, authors=刘芬
1a, 李晓石
1b, 张慧明
1b, authorsList=刘芬, 李晓石, 张慧明, authorCompany=null, correspAuthors=张慧明, authorNote=
刘芬（1985-），女，主治医师，主要从事肿瘤临床与基础研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=rOQ+J84GcX96LRzhpYRuYw==, magXml=TNNp/v/qXyeblQ++kOnWPA==, pdfUrl=null, pdf=y+Bai+tDaSKdi61+i7sw2A==, pdfFileSize=1511731, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=m7wYCKuxYnmu1GrKSRJXEA==, mapNumber=null, fund=null)}, authors=[Author(id=1291404303445517183, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404303516820353, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, authorId=1291404303445517183, language=EN, stringName=Fen LIU, firstName=Fen, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, address=
1a.Department of Pathology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404303588123522, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, authorId=1291404303445517183, language=CN, stringName=刘芬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1a, address=
1a.新乡市中心医院/新乡医学院 第四临床学院，病理科，河南 新乡 453000, bio={"content":"
刘芬（1985-），女，主治医师，主要从事肿瘤临床与基础研究
"}, bioImg=null, bioContent=
刘芬（1985-），女，主治医师，主要从事肿瘤临床与基础研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404303260967800, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, xref=1a., ext=[AuthorCompanyExt(id=1291404303273550713, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303260967800, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.Department of Pathology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291404303281939322, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303260967800, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.新乡市中心医院/新乡医学院 第四临床学院，病理科，河南 新乡 453000)])]), Author(id=1291404303663620996, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404303726535558, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, authorId=1291404303663620996, language=EN, stringName=Xiao-shi LI, firstName=Xiao-shi, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1b, address=
1b.Department of Urology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404303797838727, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, authorId=1291404303663620996, language=CN, stringName=李晓石, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1b, address=
1b.新乡市中心医院/新乡医学院 第四临床学院，泌尿外科，河南 新乡 453000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404303357436795, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, xref=1b., ext=[AuthorCompanyExt(id=1291404303365825404, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303357436795, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.Department of Urology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291404303374214013, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303357436795, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.新乡市中心医院/新乡医学院 第四临床学院，泌尿外科，河南 新乡 453000)])]), Author(id=1291404303881724809, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=253043632@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291404303944639371, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, authorId=1291404303881724809, language=EN, stringName=Hui-ming ZHANG, firstName=Hui-ming, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1b, address=
1b.Department of Urology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404304011748236, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, authorId=1291404303881724809, language=CN, stringName=张慧明, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1b, address=
1b.新乡市中心医院/新乡医学院 第四临床学院，泌尿外科，河南 新乡 453000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404303357436795, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, xref=1b., ext=[AuthorCompanyExt(id=1291404303365825404, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303357436795, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.Department of Urology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291404303374214013, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303357436795, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.新乡市中心医院/新乡医学院 第四临床学院，泌尿外科，河南 新乡 453000)])])], keywords=[Keyword(id=1291404304095634317, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=EN, orderNo=1, keyword=ulinastatin), Keyword(id=1291404304162743182, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=EN, orderNo=2, keyword=bladder cancer), Keyword(id=1291404304213074831, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=EN, orderNo=3, keyword=survival rate), Keyword(id=1291404304271795088, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=EN, orderNo=4, keyword=invasion), Keyword(id=1291404304343098257, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=EN, orderNo=5, keyword=migration), Keyword(id=1291404304410207122, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=EN, orderNo=6, keyword=epithelial-mesenchymal transition), Keyword(id=1291404304489898899, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=CN, orderNo=1, keyword=乌司他丁), Keyword(id=1291404304582173588, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=CN, orderNo=2, keyword=膀胱癌), Keyword(id=1291404304649282453, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=CN, orderNo=3, keyword=存活率), Keyword(id=1291404304712197014, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=CN, orderNo=4, keyword=侵袭), Keyword(id=1291404304783500183, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=CN, orderNo=5, keyword=迁移), Keyword(id=1291404304854803352, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, language=CN, orderNo=6, keyword=上皮间质转化)], refs=null, funds=[Fund(id=1291404304959660953, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, awardId=LHGJ20220992, language=CN, fundingSource=河南省医学科技攻关计划基金资助项目(LHGJ20220992), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291404303260967800, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, xref=1a., ext=[AuthorCompanyExt(id=1291404303273550713, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303260967800, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.Department of Pathology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291404303281939322, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303260967800, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1a.新乡市中心医院/新乡医学院 第四临床学院，病理科，河南 新乡 453000)]), AuthorCompany(id=1291404303357436795, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, xref=1b., ext=[AuthorCompanyExt(id=1291404303365825404, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303357436795, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.Department of Urology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291404303374214013, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404300878603125, companyId=1291404303357436795, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1b.新乡市中心医院/新乡医学院 第四临床学院，泌尿外科，河南 新乡 453000)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.04.009, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.04.009, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.04.009, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.04.009, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1740672000000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
3
1
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
