Article(id=1291404300102652452, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1726416000000, receivedDateStr=2024-09-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824378276, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824378276, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824378276, creator=13701087609, updateTime=1785824378276, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=507, endPage=511, ext={EN=ArticleExt(id=1291404300421419557, articleId=1291404300102652452, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of Polygonum orientale flower extract on the rats with exercise arrhythmia, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects and mechanism of Polygonum orientale flower (POR) extract on exercise arrhythmia (EA) in rats after exhaustive exercise.
Methods The EA rat model was induced by 8 weeks of exhaustive weight-bearing swimming exercise and was randomly divided into model group and experimental -L, -M, -H groups, with 12 rats per group. Twelve normal rats were selected as the normal group. On the modeling day, normal and model groups were given pure water by intragastric administration. Experimental -L, -M, -H groups were given 50, 100 and 200 mg·kg-1 POR extract solution by intragastric administration, respectively. Five groups were administrated with once a day for 8 weeks. The latent time and duration of arrhythmia in rats were detected by electrocardiograph. The contents of adenosine triphosphate (ATP), the activities of Na+/K+ATP and the contents of superoxide dismutase (SOD) in myocardial tissue were measured by corresponding kit. The transcriptional levels of calmodulin (CaM) and calmodulin dependent protein kinase Ⅱ (CaMK Ⅱ) in rat myocardium were measured by real-time fluorescence quantitative polymerase chain reaction.
Results The latent time of arrhythmia in experimental -M, -H groups and model group were (9.77±1.48), (10.61±1.61) and (7.44±2.12) min; the duration were (33.25±6.39), (20.01±3.89) and (71.44±13.68) min. The ATP contents in experimental -M, -H groups, model group and normal group were (26.45±2.96), (29.44±1.89), (10.38±1.22) and (34.50±4.24) ng·g prot-1; the Na+/K+ ATP activities were (17.27±0.92), (19.57±1.33), (5.14±0.80) and (20.00±2.11) U·g prot-1; SOD contents were (89.22±9.07), (86.29±7.22), (73.62±7.36) and (89.43±8.85) U·mg prot-1; the relative expression levels of CaM mRNA in myocardial tissue were 1.28±0.08, 1.06±0.08, 2.34±0.30 and 1.00±0.10; the relative expression levels of CaMK Ⅱ mRNA in myocardial tissue were 1.46±0.09, 1.15±0.09, 2.80±0.19 and 1.00±0.11, respectively. Compared with model group, the differences of above indexes in experimental -M, -H groups were statistically significant (all P<0.05).
Conclusion POR extract can effectively treat the rats with EA, and the mechanism is related to the increase of ATP contents, Na+/K+ ATP and antioxidant activities, and inhibition of Ca2+/CaM/CaMK Ⅱ signaling pathway.
, authors=Zhan-yi LING
1, Ru-la SA
2, Cui-hua LI
3, authorsList=Zhan-yi LING, Ru-la SA, Cui-hua LI, authorCompany=null, correspAuthors=Ru-la SA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404301218337318, articleId=1291404300102652452, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=荭草花提取物治疗运动性心律失常大鼠的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探索荭草花（POR）提取物对力竭运动后大鼠运动性心律失常（EA）的影响，及其作用机制。
方法 通过8周负重力竭游泳运动的方式诱导EA大鼠模型，并随机分为模型组和低、中、高剂量实验组，每组12只；另选12只正常大鼠作为正常组。在建模当天，正常组和模型组均灌胃给予纯净水；低、中、高剂量实验组分别灌胃给予50、100和200 mg·kg-1 POR提取物溶液。5组大鼠每天给药1次，连续给药8周。用心电图仪检测大鼠心律失常的潜伏时间和持续时间，用试剂盒测定心肌组织中腺苷三磷酸（ATP）含量、Na+/K+ ATP酶活性和超氧化物歧化酶（SOD）含量，用实时荧光定量聚合酶链反应检测大鼠心肌组织中钙调蛋白（CaM）和钙调蛋白依赖性蛋白激酶Ⅱ（CaMK Ⅱ）的转录水平。
结果 中、高剂量实验组和模型组的心律失常潜伏时间分别为（9.77±1.48）、（10.61±1.61）和（7.44±2.12）min，持续时间分别为（33.25±6.39）、（20.01±3.89）和（71.44±13.68）min；中、高剂量实验组和模型组、正常组的ATP含量分别为（26.45±2.96）、（29.44±1.89）、（10.38±1.22）和（34.50±4.24）ng·g prot-1，Na+/K+ ATP酶活性分别为（17.27±0.92）、（19.57±1.33）、（5.14±0.80）和（20.00±2.11）U·g prot-1，SOD含量分别为（89.22±9.07）、（86.29±7.22）、（73.62±7.36）和（89.43±8.85）U·mg prot-1，心肌组织中CaM mRNA相对表达水平分别为1.28±0.08、1.06±0.08、2.34±0.30和1.00±0.10，心肌组织中CaMK Ⅱ mRNA相对表达水平分别为1.46±0.09、1.15±0.09、2.80±0.19和1.00±0.11。中、高剂量实验组的上述指标与模型组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 POR提取物可以有效治疗EA大鼠，其机制与提高ATP含量、Na+/K+ ATP酶活性和抗氧化活性，以及抑制Ca2+/CaM/CaMK Ⅱ信号通路有关。
, authors=凌占一
1, 萨如拉
2, 李翠花
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凌占一（1982-），男，教授，主要从事体育训练学的相关研究及教学工作
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