Article(id=1291404287851094816, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728489600000, receivedDateStr=2024-10-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824375355, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824375355, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824375355, creator=13701087609, updateTime=1785824375355, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=462, endPage=466, ext={EN=ArticleExt(id=1291404289440736033, articleId=1291404287851094816, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical comparative study of medroxyprogesterone acetate and dienogest in the treatment of patients with endometriosis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy of medroxyprogesterone acetate and dinogestrel in the treatment of endometriosis (EMs) respectively.
Methods EMs patients were divided into control group and treatment group according to cohort methods. Control group was given oral treatment with medroxyprogesterone acetate tablets, 10 mg each time, tid. Treatment group was given oral treatment with dinorgestrel tablets, 2 mg each time, qd. Patients in both groups continued to take the drug for 6 menstrual cycles. The levels of clinical efficacy, basal follicle-stimulating hormone (bF-SH), basal estradiol (bE2), anral follicle count (AFC) and anti-mullerian hormone (AMH) before and after treatment were compared between the two groups.
Results In this trial, 38 cases were enrolled in the control group and 42 cases in the treatment group. After treatment, the total effective rates of the treatment group and the control group were 90.48% (38 cases / 42 cases) and 71.05% (27 cases / 38 cases), respectively, and the difference was statistically significant (P<0.05). After treatment, the levels of bF-SH in the treatment group and control group were (11.25±3.02) and (13.41±3.56) IU·L-1, respectively; the bE2 levels were (2.14±0.63) and (2.58±0.87) pmol·L-1, respectively; the AFC levels were 7.80±1.69 and 6.97±1.63, respectively; the AMH levels were (1.12±0.14) and (1.03±0.21) ng·mL-1, respectively; the above indexes were statistically significant (P<0.01,P<0.001). The adverse drug reactions of the treatment group mainly included abnormal vaginal bleeding, hot flashes and increased body weight, while the adverse drug reactions of the control group mainly included bleeding and hot flashes. The incidence of total adverse drug reactions in the treatment group and the control group was 11.90% (5 cases/42 cases) and 7.89% (3 cases/38 cases), respectively, and the difference was not statistically significant (P>0.05).
Conclusion Dienogest tablets has a good effect in the treatment of EMs patients, which can effectively relieve pain symptoms, inhibit estrogen expression, improve uterine artery blood flow, and reduce the level of inflammation in the body, with low adverse drug reactions.
, authors=Jing-wen MA, Shu-xia HAN, Zhi-juan YANG, authorsList=Jing-wen MA, Shu-xia HAN, Zhi-juan YANG, authorCompany=null, correspAuthors=Zhi-juan YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404290065687330, articleId=1291404287851094816, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=醋酸甲羟孕酮与地诺孕素治疗子宫内膜异位症患者的临床对比研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察醋酸甲羟孕酮片与地诺孕素片分别治疗子宫内膜异位症（EMs）的临床疗效及安全性。
方法 将EMs患者按队列法分为对照组和试验组。对照组患者给予醋酸甲羟孕酮片口服治疗，每次10 mg，tid。试验组患者给予地诺孕素片口服治疗，每次2 mg，qd。2组患者均持续用药6个月经周期。比较2组患者治疗前后的临床疗效、基础卵泡刺激素（bF-SH）、基础雌二醇（bE2）、窦卵泡计数（AFC）及抗苗勒管激素（AMH）水平，并进行安全性评价。
结果 本研究对照组入组38例，试验组入组42例。治疗后，试验组和对照组的总有效率分别为90.48%（38例/42例）和71.05%（27例/38例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的bF-SH水平分别为（11.25±3.02）和（13.41±3.56）IU·L-1，bE2水平分别为（2.14±0.63）和（2.58±0.87）pmol·L-1，AFC水平分别为（7.80±1.69）和（6.97±1.63）个，AMH水平分别为（1.12±0.14）和（1.03±0.21）ng·mL-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（P<0.01，P<0.001）。试验组的药物不良反应主要有阴道异常出血、潮热、体质量增加，对照组的药物不良反应主要有出血、潮热。试验组和对照组的药物不良反应总发生率分别为11.90%（5例/42例）和7.89%（3例/38例），在统计学上差异无统计学意义（P>0.05）。
结论 地诺孕素片治疗EMs患者的效果较好，可以有效缓解患者疼痛症状，抑制雌激素表达，改善子宫动脉血流，降低机体炎症水平，药物不良反应较低。
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马静文（1987-），女，副主任医师，主要从事妇科内分泌疾病及妇科肿瘤临床诊疗方面的工作
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