Article(id=1291404285519061769, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1726329600000, receivedDateStr=2024-09-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824374798, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824374798, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824374798, creator=13701087609, updateTime=1785824374798, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=451, endPage=456, ext={EN=ArticleExt(id=1291404285724582666, articleId=1291404285519061769, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical characteristics and pathogenic analysis of acute empyema in adults, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To analyze the clinical characteristics and distribution of pathogens in adult acute empyema.

Methods

Adult patients with acute empyema were divided into the control group (patients with community-acquired empyema) and the treatment group (patients with hospital-acquired empyema) according to cohort method. The general data, clinical manifestations, laboratory examinations, imaging data, antimicrobial drugs use, invasive treatment and outcomes of the two groups were collected and compared.

Results

There were 59 cases in the treatment group and 102 cases in the control group. Compared with the control group, the proportion of lung abscess in the treatment group was lower (1.69% vs 10.78%, P<0.05), the proportion of pneumothorax, positive rates of pus culture and mixed infection were higher (47.46% vs 18.63%, 55.93% vs 24.51%, 27.12% vs 1.96%, all P<0.05). In the control group, 27 strains of pathogens were isolated, predominantly Gram-positive cocci (74.07%), with Streptococcus anginosus group being the most common (44.44%). In the treatment group, 52 strains were isolated, predominantly Gram-negative bacilli (67.31%), with Pseudomonas aeruginosa being the most common (21.15%). Streptococcus anginosus group was sensitive to penicilins and cephalosporins, while the multidrug resistance rate of Gram-negative bacilli was high, with Pseudomonas aeruginosa showing a 69.23% resistance to meropenem. Six patients in total died, all from the treatment group and receiving non-surgical treatment, due to malignant tumors or hospital-acquired pneumonia.

Conclusion

In adult acute empyema, non-parapneumonic empyema is common, and there were significant differences in the pathogenic distribution between community-acquired empyema and hospital-acquired empyema.

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目的

分析成人急性脓胸的临床特征及病原学分布特点。

方法

将成人急性脓胸患者按队列法分为对照组(社区获得性脓胸患者)和试验组(医院获得性脓胸患者)。收集并比较2组患者的一般资料、临床表现、实验室检查、影像学资料、抗菌药物使用情况、有创治疗手段及结局转归。

结果

试验组入组59例,对照组入组102例。试验组与对照组相比,肺脓肿构成比更低(1.69% vs 10.78%,P<0.05),气胸构成比、脓液培养阳性率及混合感染占比更高(47.46% vs 18.63%、55.93% vs 24.51%、27.12% vs 1.96%,均P<0.05)。对照组脓液培养检出致病菌27株,以革兰氏阳性球菌为主(74.07%),咽峡炎链球菌群占比最高(44.44%);试验组检出52株,以革兰氏阴性杆菌为主(67.31%),铜绿假单胞菌占比最高(21.15%)。咽峡炎链球菌群对青霉素、头孢菌素均敏感;革兰氏阴性杆菌多重耐药率高,其中铜绿假单胞菌对美罗培南耐药率为69.23%。所有患者中有6例发生临床死亡,均属试验组、均属于非手术治疗患者,死因为恶性肿瘤或医院获得性肺炎。

结论

成人急性脓胸以非肺炎旁脓胸更常见,社区获得性脓胸和医院获得性脓胸的病原学分布存在显著差异。

, authors=辛彩焕, 熊辉, authorsList=辛彩焕, 熊辉, authorCompany=null, correspAuthors=熊辉, authorNote=

辛彩焕(1986-),女,主治医师,主要从事急诊科的临床诊疗工作

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熊辉,主任医师,硕士生导师 MP: 13911875206 E-mail:
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成人急性脓胸的临床特征及病原学分析
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辛彩焕 , 熊辉
中国临床药理学杂志 | 临床与基础桥接研究 2025,41(4): 451-456
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中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (4) : 451 -456
成人急性脓胸的临床特征及病原学分析
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辛彩焕, 熊辉
作者信息
  • 北京大学 第一医院 急诊科,北京 100034
通讯作者:
熊辉,主任医师,硕士生导师 MP: 13911875206 E-mail:
作者简介:

辛彩焕(1986-),女,主治医师,主要从事急诊科的临床诊疗工作

Clinical characteristics and pathogenic analysis of acute empyema in adults
Cai-huan XIN, Hui XIONG
Affiliations
  • Emergency Department, Peking University First Hospital, Beijing 100034, China
出版时间: 2025-02-28 doi: 10.13699/j.cnki.1001-6821.2025.04.001
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目的

分析成人急性脓胸的临床特征及病原学分布特点。

方法

将成人急性脓胸患者按队列法分为对照组(社区获得性脓胸患者)和试验组(医院获得性脓胸患者)。收集并比较2组患者的一般资料、临床表现、实验室检查、影像学资料、抗菌药物使用情况、有创治疗手段及结局转归。

结果

试验组入组59例,对照组入组102例。试验组与对照组相比,肺脓肿构成比更低(1.69% vs 10.78%,P<0.05),气胸构成比、脓液培养阳性率及混合感染占比更高(47.46% vs 18.63%、55.93% vs 24.51%、27.12% vs 1.96%,均P<0.05)。对照组脓液培养检出致病菌27株,以革兰氏阳性球菌为主(74.07%),咽峡炎链球菌群占比最高(44.44%);试验组检出52株,以革兰氏阴性杆菌为主(67.31%),铜绿假单胞菌占比最高(21.15%)。咽峡炎链球菌群对青霉素、头孢菌素均敏感;革兰氏阴性杆菌多重耐药率高,其中铜绿假单胞菌对美罗培南耐药率为69.23%。所有患者中有6例发生临床死亡,均属试验组、均属于非手术治疗患者,死因为恶性肿瘤或医院获得性肺炎。

结论

成人急性脓胸以非肺炎旁脓胸更常见,社区获得性脓胸和医院获得性脓胸的病原学分布存在显著差异。

脓胸  /  临床特征  /  病原学
Objective

To analyze the clinical characteristics and distribution of pathogens in adult acute empyema.

Methods

Adult patients with acute empyema were divided into the control group (patients with community-acquired empyema) and the treatment group (patients with hospital-acquired empyema) according to cohort method. The general data, clinical manifestations, laboratory examinations, imaging data, antimicrobial drugs use, invasive treatment and outcomes of the two groups were collected and compared.

Results

There were 59 cases in the treatment group and 102 cases in the control group. Compared with the control group, the proportion of lung abscess in the treatment group was lower (1.69% vs 10.78%, P<0.05), the proportion of pneumothorax, positive rates of pus culture and mixed infection were higher (47.46% vs 18.63%, 55.93% vs 24.51%, 27.12% vs 1.96%, all P<0.05). In the control group, 27 strains of pathogens were isolated, predominantly Gram-positive cocci (74.07%), with Streptococcus anginosus group being the most common (44.44%). In the treatment group, 52 strains were isolated, predominantly Gram-negative bacilli (67.31%), with Pseudomonas aeruginosa being the most common (21.15%). Streptococcus anginosus group was sensitive to penicilins and cephalosporins, while the multidrug resistance rate of Gram-negative bacilli was high, with Pseudomonas aeruginosa showing a 69.23% resistance to meropenem. Six patients in total died, all from the treatment group and receiving non-surgical treatment, due to malignant tumors or hospital-acquired pneumonia.

Conclusion

In adult acute empyema, non-parapneumonic empyema is common, and there were significant differences in the pathogenic distribution between community-acquired empyema and hospital-acquired empyema.

empyema  /  clinical feature  /  pathogen
辛彩焕, 熊辉. 成人急性脓胸的临床特征及病原学分析. 中国临床药理学杂志, 2025 , 41 (4) : 451 -456 . DOI: 10.13699/j.cnki.1001-6821.2025.04.001
Cai-huan XIN, Hui XIONG. Clinical characteristics and pathogenic analysis of acute empyema in adults[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (4) : 451 -456 . DOI: 10.13699/j.cnki.1001-6821.2025.04.001
  • 中央高水平医院临床科研业务费(北京大学第一医院青年临床研究专项基金)资助项目(2023YC17)
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doi: 10.13699/j.cnki.1001-6821.2025.04.001
  • 接收时间:2024-09-15
  • 首发时间:2026-08-04
  • 出版时间:2025-02-28
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  • 收稿日期:2024-09-15
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中央高水平医院临床科研业务费(北京大学第一医院青年临床研究专项基金)资助项目(2023YC17)
作者信息
    北京大学 第一医院 急诊科,北京 100034

通讯作者:

熊辉,主任医师,硕士生导师 MP: 13911875206 E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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