首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1291339289028190865, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1716998400000, receivedDateStr=2024-05-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808878428, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808878428, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808878428, creator=13041195026, updateTime=1785808878428, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=361, endPage=365, ext={EN=ArticleExt(id=1291339289258877586, articleId=1291339289028190865, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Non-targeted metabolomics research of harmine anti-Echinococcus granulosus in vitro, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the mechanism of action of harmine (HM) in anti-Echinococcus granulosus (E.g) based on non-targeted metabolomics.

Methods

The aseptically cultured fine-grained E.g was divided into blank group (KB group, conventional culture), solvent group (DMSO group, DMSO 2 μL) and administration group (HM group, 20 mmoL·L-1 HM solution 2 μL). Survival rate was observed by eosin staining after 48 h of intervention and the ultrastructural changes were observed by scanning electron microscopy, respectively. Meanwhile, non-targeted metabolomics analysis was performed based on ultra performance liquid chromatography-mass spectrometry (UPLC-MS/MS) technology on each group of E.g to screen the differential metabolites and explore the effect of harmine on the metabolic profile of E.g.

Results

Eosin staining and scanning electron microscopy results showed that harmine had a significant inhibitory effect on E.g in vitro. Metabolomics results showed that there were a total of 15 metabolites with significant differences between the harmine and blank groups (all P<0.05). Enrichment of the differential metabolites by Kyoto Encyclopedia of Genes and Genomes (KEGG) showed that harmine mainly affected the metabolic pathways of amino acid metabolism, fatty acid metabolism and nucleotide metabolism in E.g.

Conclusion

Harmine had a significant inhibitory effect on E.g, the mechanism of which may be related to the regulation of amino acid metabolism, fatty acid metabolism and nucleotide metabolism pathways, which can provide a new way of thinking for the development of the subsequent anti-cystic echinococlosis drug targets.

, authors=Qin-wei XU1, Hui-jing GAO2, 3, KADIERYA Ku-er-ban1, Qin MA4, Liang TENG2, 3, authorsList=Qin-wei XU, Hui-jing GAO, KADIERYA Ku-er-ban, Qin MA, Liang TENG, authorCompany=null, correspAuthors=Liang TENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339289594421907, articleId=1291339289028190865, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=去氢骆驼蓬碱体外抗细粒棘球蚴的非靶向代谢组学研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

基于非靶向代谢组学研究去氢骆驼蓬碱（HM）抑制细粒棘球蚴的作用机制。

方法

将无菌培养的细粒棘球蚴分为空白组（KB组，常规培养）、溶剂组（DMSO组，DMSO 2 μL）及给药组（HM组，20 mmoL·L-1HM溶液2 μL），干预48 h后伊红染色观察其存活率，扫描电镜观察其超微结构变化。同时，基于超高效液相色谱-质谱联用（UPLC-MS/MS）技术对各组细粒棘球蚴进行非靶向代谢组学分析，筛选差异代谢物，探究HM对细粒棘球蚴代谢谱的影响。

结果

伊红染色及扫描电镜结果显示，HM在体外对细粒棘球蚴具有明显的抑制作用。代谢组学结果显示，HM组与KB组共有15种具有显著差异的代谢物（均P<0.05）。将差异代谢物经京都基因与基因组百科全书（KEGG）富集后，结果显示HM主要影响细粒棘球蚴的氨基酸代谢、脂肪酸代谢及核苷酸代谢等代谢通路。

结论

HM对细粒棘球蚴具有显著的抑制作用，其机制可能与调节氨基酸代谢、脂肪酸代谢和核苷酸代谢等途径相关，可以为后续抗囊型包虫病药物靶点的开发提供新思路。

, authors=徐勤伟1, 高惠静2, 3, 卡地尔亚·库尔班1, 马芹4, 滕亮2, 3, authorsList=徐勤伟, 高惠静, 卡地尔亚·库尔班, 马芹, 滕亮, authorCompany=null, correspAuthors=滕亮, authorNote=

徐勤伟（1999-），男，硕士研究生，主要从事新药研发相关的研究

, correspAuthorsNote=
滕亮，主任药师 MP: 15899225212 E-mail:
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=Qk4L0MuCM1JdiWQrwUiB0g==, magXml=PE3kYjcKWkzVg/Zt2RGJGw==, pdfUrl=null, pdf=h3Zoib0uLljfOAYWqzrTWQ==, pdfFileSize=2273549, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=WD+VlpdLusuuhaCWTqq4Pg==, mapNumber=null, fund=null)}, authors=[Author(id=1291339291343446689, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339291486053027, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339291343446689, language=EN, stringName=Qin-wei XU, firstName=Qin-wei, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339291569939108, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339291343446689, language=CN, stringName=徐勤伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011, bio={"content":"

徐勤伟（1999-），男，硕士研究生，主要从事新药研发相关的研究

"}, bioImg=null, bioContent=

徐勤伟（1999-），男，硕士研究生，主要从事新药研发相关的研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339289770582676, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=1., ext=[AuthorCompanyExt(id=1291339289778971285, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289812525718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011)])]), Author(id=1291339291645436582, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339291972592297, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339291645436582, language=EN, stringName=Hui-jing GAO, firstName=Hui-jing, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, address=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339292031312554, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339291645436582, language=CN, stringName=高惠静, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, address=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054
3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339289883828887, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=2., ext=[AuthorCompanyExt(id=1291339289892217496, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289900606105, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054)]), AuthorCompany(id=1291339289967714970, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=3., ext=[AuthorCompanyExt(id=1291339289976103579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289980297884, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054)])]), Author(id=1291339292111004332, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339292350079662, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339292111004332, language=EN, stringName=KADIERYA Ku-er-ban, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339292433965743, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339292111004332, language=CN, stringName=卡地尔亚·库尔班, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339289770582676, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=1., ext=[AuthorCompanyExt(id=1291339289778971285, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289812525718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011)])]), Author(id=1291339292773704369, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339293163774643, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339292773704369, language=EN, stringName=Qin MA, firstName=Qin, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4.Xinjiang Huashidan Pharmaceutical Co., Ltd., Urumqi 830011, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339293243466420, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339292773704369, language=CN, stringName=马芹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4.新疆华世丹药业股份有限公司，新疆维吾尔自治区 乌鲁木齐 830011, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339291234394781, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=4., ext=[AuthorCompanyExt(id=1291339291246977694, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339291234394781, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4.Xinjiang Huashidan Pharmaceutical Co., Ltd., Urumqi 830011, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339291272143519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339291234394781, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4.新疆华世丹药业股份有限公司，新疆维吾尔自治区 乌鲁木齐 830011)])]), Author(id=1291339293310575286, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=tl750212@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291339293650313913, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339293310575286, language=EN, stringName=Liang TENG, firstName=Liang, middleName=null, lastName=TENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, address=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339293725811386, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339293310575286, language=CN, stringName=滕亮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, address=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054
3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339289883828887, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=2., ext=[AuthorCompanyExt(id=1291339289892217496, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289900606105, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054)]), AuthorCompany(id=1291339289967714970, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=3., ext=[AuthorCompanyExt(id=1291339289976103579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289980297884, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054)])])], keywords=[Keyword(id=1291339294011024059, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=EN, orderNo=1, keyword=harmine), Keyword(id=1291339294090715836, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=EN, orderNo=2, keyword=non-targeted metabolomics), Keyword(id=1291339294149436093, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=EN, orderNo=3, keyword=Echinococcus granulosus), Keyword(id=1291339294220739262, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=EN, orderNo=4, keyword=amino acid metabolism), Keyword(id=1291339294447231679, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=EN, orderNo=5, keyword=fatty acid metabolism), Keyword(id=1291339294518534848, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=CN, orderNo=1, keyword=去氢骆驼蓬碱), Keyword(id=1291339294602420929, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=CN, orderNo=2, keyword=非靶向代谢组学), Keyword(id=1291339294887633602, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=CN, orderNo=3, keyword=细粒棘球蚴), Keyword(id=1291339294958936771, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=CN, orderNo=4, keyword=氨基酸代谢), Keyword(id=1291339295260926660, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, language=CN, orderNo=5, keyword=脂肪酸代谢)], refs=null, funds=[Fund(id=1291339295390950085, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, awardId=SKL-HIDCA-2022-BC3; SKL-HIDCA-2023-YX1, language=CN, fundingSource=省部共建中亚高发病成因与防治国家重点实验室开放课题基金资助项目(SKL-HIDCA-2022-BC3; SKL-HIDCA-2023-YX1), fundOrder=null, country=null), Fund(id=1291339295705522886, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, awardId=2022B03013-4, language=CN, fundingSource=新疆维吾尔自治区重点研发基金资助项目(2022B03013-4), fundOrder=null, country=null), Fund(id=1291339295785214663, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, awardId=2023D01D16; 2023D01A120, language=CN, fundingSource=新疆维吾尔自治区自然科学基金资助项目(2023D01D16; 2023D01A120), fundOrder=null, country=null), Fund(id=1291339296108176072, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, awardId=Z-2021-46-2101-2023, language=CN, fundingSource=中华国际医学交流会基金会-中华医学会临床药学分会临床药学科研基金资助项目(Z-2021-46-2101-2023), fundOrder=null, country=null), Fund(id=1291339296187867849, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, awardId=2023AB009-04, language=CN, fundingSource=兵团科技攻关计划基金资助项目(2023AB009-04), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291339289770582676, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=1., ext=[AuthorCompanyExt(id=1291339289778971285, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289812525718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011)]), AuthorCompany(id=1291339289883828887, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=2., ext=[AuthorCompanyExt(id=1291339289892217496, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289900606105, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054)]), AuthorCompany(id=1291339289967714970, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=3., ext=[AuthorCompanyExt(id=1291339289976103579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289980297884, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054)]), AuthorCompany(id=1291339291234394781, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=4., ext=[AuthorCompanyExt(id=1291339291246977694, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339291234394781, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4.Xinjiang Huashidan Pharmaceutical Co., Ltd., Urumqi 830011, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339291272143519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339291234394781, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4.新疆华世丹药业股份有限公司，新疆维吾尔自治区 乌鲁木齐 830011)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.03.013, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.03.013, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.03.013, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.03.013, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1739721600000, fullTextJson=null, articleText=null, reference=null)
收藏切换
去氢骆驼蓬碱体外抗细粒棘球蚴的非靶向代谢组学研究
收藏切换
PDF下载
徐勤伟 1 , 高惠静 2, 3 , 卡地尔亚·库尔班 1 , 马芹 4 , 滕亮 2, 3
中国临床药理学杂志 | 临床与基础桥接研究 2025,41(3): 361-365
收起
收藏切换
中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (3) : 361 -365
去氢骆驼蓬碱体外抗细粒棘球蚴的非靶向代谢组学研究
全屏
[Author(id=1291339291343446689, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339291486053027, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339291343446689, language=EN, stringName=Qin-wei XU, firstName=Qin-wei, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339291569939108, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339291343446689, language=CN, stringName=徐勤伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011, bio={"content":"

徐勤伟（1999-），男，硕士研究生，主要从事新药研发相关的研究

"}, bioImg=null, bioContent=

徐勤伟（1999-），男，硕士研究生，主要从事新药研发相关的研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339289770582676, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=1., ext=[AuthorCompanyExt(id=1291339289778971285, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289812525718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011)])]), Author(id=1291339291645436582, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339291972592297, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339291645436582, language=EN, stringName=Hui-jing GAO, firstName=Hui-jing, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, address=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339292031312554, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339291645436582, language=CN, stringName=高惠静, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, address=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054
3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339289883828887, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=2., ext=[AuthorCompanyExt(id=1291339289892217496, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289900606105, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054)]), AuthorCompany(id=1291339289967714970, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=3., ext=[AuthorCompanyExt(id=1291339289976103579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289980297884, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054)])]), Author(id=1291339292111004332, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339292350079662, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339292111004332, language=EN, stringName=KADIERYA Ku-er-ban, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339292433965743, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339292111004332, language=CN, stringName=卡地尔亚·库尔班, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=1, address=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339289770582676, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=1., ext=[AuthorCompanyExt(id=1291339289778971285, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289812525718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289770582676, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011)])]), Author(id=1291339292773704369, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339293163774643, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339292773704369, language=EN, stringName=Qin MA, firstName=Qin, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4.Xinjiang Huashidan Pharmaceutical Co., Ltd., Urumqi 830011, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339293243466420, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339292773704369, language=CN, stringName=马芹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=4, address=4.新疆华世丹药业股份有限公司，新疆维吾尔自治区 乌鲁木齐 830011, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339291234394781, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=4., ext=[AuthorCompanyExt(id=1291339291246977694, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339291234394781, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4.Xinjiang Huashidan Pharmaceutical Co., Ltd., Urumqi 830011, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339291272143519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339291234394781, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=4.新疆华世丹药业股份有限公司，新疆维吾尔自治区 乌鲁木齐 830011)])]), Author(id=1291339293310575286, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=tl750212@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291339293650313913, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339293310575286, language=EN, stringName=Liang TENG, firstName=Liang, middleName=null, lastName=TENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, address=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339293725811386, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, authorId=1291339293310575286, language=CN, stringName=滕亮, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=2, 3, address=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054
3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339289883828887, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=2., ext=[AuthorCompanyExt(id=1291339289892217496, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289900606105, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289883828887, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054)]), AuthorCompany(id=1291339289967714970, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, xref=3., ext=[AuthorCompanyExt(id=1291339289976103579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China), AuthorCompanyExt(id=1291339289980297884, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339289028190865, companyId=1291339289967714970, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054)])])]
徐勤伟1, 高惠静2, 3, 卡地尔亚·库尔班1, 马芹4, 滕亮2, 3
作者信息
  • 1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011
  • 2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054
  • 3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054
  • 4.新疆华世丹药业股份有限公司，新疆维吾尔自治区 乌鲁木齐 830011
通讯作者:
滕亮，主任药师 MP: 15899225212 E-mail:
作者简介:

徐勤伟（1999-），男，硕士研究生，主要从事新药研发相关的研究

Non-targeted metabolomics research of harmine anti-Echinococcus granulosus in vitro
Qin-wei XU1, Hui-jing GAO2, 3, KADIERYA Ku-er-ban1, Qin MA4, Liang TENG2, 3
Affiliations
  • 1.College of Pharmacy, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
  • 2.State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • 3.Department of Pharmacy, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
  • 4.Xinjiang Huashidan Pharmaceutical Co., Ltd., Urumqi 830011, Xinjiang Uygur Autonomous Region, China
出版时间: 2025-02-17 doi: 10.13699/j.cnki.1001-6821.2025.03.013
文章导航
收藏切换
摘要
收起
目的

基于非靶向代谢组学研究去氢骆驼蓬碱（HM）抑制细粒棘球蚴的作用机制。

方法

将无菌培养的细粒棘球蚴分为空白组（KB组，常规培养）、溶剂组（DMSO组，DMSO 2 μL）及给药组（HM组，20 mmoL·L-1HM溶液2 μL），干预48 h后伊红染色观察其存活率，扫描电镜观察其超微结构变化。同时，基于超高效液相色谱-质谱联用（UPLC-MS/MS）技术对各组细粒棘球蚴进行非靶向代谢组学分析，筛选差异代谢物，探究HM对细粒棘球蚴代谢谱的影响。

结果

伊红染色及扫描电镜结果显示，HM在体外对细粒棘球蚴具有明显的抑制作用。代谢组学结果显示，HM组与KB组共有15种具有显著差异的代谢物（均P<0.05）。将差异代谢物经京都基因与基因组百科全书（KEGG）富集后，结果显示HM主要影响细粒棘球蚴的氨基酸代谢、脂肪酸代谢及核苷酸代谢等代谢通路。

结论

HM对细粒棘球蚴具有显著的抑制作用，其机制可能与调节氨基酸代谢、脂肪酸代谢和核苷酸代谢等途径相关，可以为后续抗囊型包虫病药物靶点的开发提供新思路。

去氢骆驼蓬碱  /  非靶向代谢组学  /  细粒棘球蚴  /  氨基酸代谢  /  脂肪酸代谢
Objective

To investigate the mechanism of action of harmine (HM) in anti-Echinococcus granulosus (E.g) based on non-targeted metabolomics.

Methods

The aseptically cultured fine-grained E.g was divided into blank group (KB group, conventional culture), solvent group (DMSO group, DMSO 2 μL) and administration group (HM group, 20 mmoL·L-1 HM solution 2 μL). Survival rate was observed by eosin staining after 48 h of intervention and the ultrastructural changes were observed by scanning electron microscopy, respectively. Meanwhile, non-targeted metabolomics analysis was performed based on ultra performance liquid chromatography-mass spectrometry (UPLC-MS/MS) technology on each group of E.g to screen the differential metabolites and explore the effect of harmine on the metabolic profile of E.g.

Results

Eosin staining and scanning electron microscopy results showed that harmine had a significant inhibitory effect on E.g in vitro. Metabolomics results showed that there were a total of 15 metabolites with significant differences between the harmine and blank groups (all P<0.05). Enrichment of the differential metabolites by Kyoto Encyclopedia of Genes and Genomes (KEGG) showed that harmine mainly affected the metabolic pathways of amino acid metabolism, fatty acid metabolism and nucleotide metabolism in E.g.

Conclusion

Harmine had a significant inhibitory effect on E.g, the mechanism of which may be related to the regulation of amino acid metabolism, fatty acid metabolism and nucleotide metabolism pathways, which can provide a new way of thinking for the development of the subsequent anti-cystic echinococlosis drug targets.

harmine  /  non-targeted metabolomics  /  Echinococcus granulosus  /  amino acid metabolism  /  fatty acid metabolism
徐勤伟, 高惠静, 卡地尔亚·库尔班, 马芹, 滕亮. 去氢骆驼蓬碱体外抗细粒棘球蚴的非靶向代谢组学研究. 中国临床药理学杂志, 2025 , 41 (3) : 361 -365 . DOI: 10.13699/j.cnki.1001-6821.2025.03.013
Qin-wei XU, Hui-jing GAO, KADIERYA Ku-er-ban, Qin MA, Liang TENG. Non-targeted metabolomics research of harmine anti-Echinococcus granulosus in vitro[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (3) : 361 -365 . DOI: 10.13699/j.cnki.1001-6821.2025.03.013
基金
收起
  • 省部共建中亚高发病成因与防治国家重点实验室开放课题基金资助项目(SKL-HIDCA-2022-BC3; SKL-HIDCA-2023-YX1)
  • 新疆维吾尔自治区重点研发基金资助项目(2022B03013-4)
  • 新疆维吾尔自治区自然科学基金资助项目(2023D01D16; 2023D01A120)
  • 中华国际医学交流会基金会-中华医学会临床药学分会临床药学科研基金资助项目(Z-2021-46-2101-2023)
  • 兵团科技攻关计划基金资助项目(2023AB009-04)
文献
收起
参考文献 引证文献
排序方式：
2025年第41卷第3期
PDF下载
3
1
引用本文
BibTeX
文章信息
doi: 10.13699/j.cnki.1001-6821.2025.03.013
  • 接收时间：2024-05-30
  • 首发时间：2026-08-04
  • 出版时间：2025-02-17
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2024-05-30
基金
省部共建中亚高发病成因与防治国家重点实验室开放课题基金资助项目(SKL-HIDCA-2022-BC3; SKL-HIDCA-2023-YX1)
新疆维吾尔自治区重点研发基金资助项目(2022B03013-4)
新疆维吾尔自治区自然科学基金资助项目(2023D01D16; 2023D01A120)
中华国际医学交流会基金会-中华医学会临床药学分会临床药学科研基金资助项目(Z-2021-46-2101-2023)
兵团科技攻关计划基金资助项目(2023AB009-04)
作者信息
    1.新疆医科大学 药学院，新疆维吾尔自治区 乌鲁木齐 830011
    2.省部共建中亚高发病成因与防治国家重点实验室，新疆维吾尔自治区 乌鲁木齐 830054
    3.新疆医科大学 第一附属医院 药学部，新疆维吾尔自治区 乌鲁木齐 830054
    4.新疆华世丹药业股份有限公司，新疆维吾尔自治区 乌鲁木齐 830011

通讯作者:

滕亮，主任药师 MP: 15899225212 E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.03.013
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257（仅加盟咨询）
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持