Article(id=1291339191779057715, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339021272211834, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.02.023, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1718553600000, receivedDateStr=2024-06-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808855242, onlineDateStr=2026-08-04, pubDate=1737993600000, pubDateStr=2025-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808855242, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808855242, creator=13041195026, updateTime=1785808855242, updator=13041195026, issue=Issue{id=1291339021272211834, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1737993600000', pubDateStr='2025-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808814590, creator='13041195026', updateTime=1785808814590, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=264, endPage=268, ext={EN=ArticleExt(id=1291339194224336948, articleId=1291339191779057715, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of autophagy in the pathogenesis of rheumatoid arthritis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

With the deepening of molecular biology and cell biology research, the regulatory mechanism of autophagy has been gradually revealed, providing new ideas for the treatment of numerous diseases. Autophagy may be closely related to pathological changes such as apoptosis resistance of fibroblast-like synoviocytes, disturbances in bone metabolic homeostasis, and antigen presentation, the regulation of autophagy homeostasis may be an important approach for the treatment of rheumatoid arthritis (RA). In this paper, we provide a review on the pathological mechanism of autophagy in RA, with a view to providing a theoretical basis for later studies.

, authors=Wen-xia QI1, Gang WANG2, Yan-feng YAN3, Jie-xiang TIAN2, Tao WANG2, Yong WEI2, Zhan-dong WANG1, Yuan-yuan ZHANG2, authorsList=Wen-xia QI, Gang WANG, Yan-feng YAN, Jie-xiang TIAN, Tao WANG, Yong WEI, Zhan-dong WANG, Yuan-yuan ZHANG, authorCompany=null, correspAuthors=Gang WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339195478433845, articleId=1291339191779057715, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=自噬在类风湿关节炎病理机制中的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

随着分子生物学和细胞生物学研究的深入,自噬的调控机制被逐渐揭示,为众多疾病的治疗提供了新的思路。自噬可能与成纤维样滑膜细胞的凋亡抵抗、骨代谢平衡紊乱、抗原提呈等病理变化密切相关,调节自噬平衡可能是治疗类风湿关节炎(RA)的重要方法。本文就自噬在RA的病理机制做一综述,以期为后期的研究提供理论依据。

, authors=漆文霞1, 王钢2, 闫彦峰3, 田杰祥2, 王涛2, 魏勇2, 汪湛东1, 张媛媛2, authorsList=漆文霞, 王钢, 闫彦峰, 田杰祥, 王涛, 魏勇, 汪湛东, 张媛媛, authorCompany=null, correspAuthors=王钢, authorNote=

漆文霞(1995-),女,博士研究生,主要从事中西医结合防治风湿病的相关研究

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王钢,主任医师,博士生导师 MP: 18419379458 E-mail:
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漆文霞(1995-),女,博士研究生,主要从事中西医结合防治风湿病的相关研究

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漆文霞(1995-),女,博士研究生,主要从事中西医结合防治风湿病的相关研究

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自噬在类风湿关节炎病理机制中的研究现状
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漆文霞 1 , 王钢 2 , 闫彦峰 3 , 田杰祥 2 , 王涛 2 , 魏勇 2 , 汪湛东 1 , 张媛媛 2
中国临床药理学杂志 | 综述 2025,41(2): 264-268
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中国临床药理学杂志 |综述 2025 , 41 (2) : 264 -268
自噬在类风湿关节炎病理机制中的研究现状
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漆文霞(1995-),女,博士研究生,主要从事中西医结合防治风湿病的相关研究

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漆文霞(1995-),女,博士研究生,主要从事中西医结合防治风湿病的相关研究

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漆文霞1, 王钢2 , 闫彦峰3, 田杰祥2, 王涛2, 魏勇2, 汪湛东1, 张媛媛2
作者信息
  • 1.甘肃中医药大学 中西医结合学院,甘肃 兰州 730000
  • 2.甘肃中医药大学 附属医院 风湿骨病科,甘肃 兰州 730020
  • 3.甘肃中医药大学 第四附属医院 呼吸与危重症医学科,甘肃 兰州 730060
通讯作者:
王钢,主任医师,博士生导师 MP: 18419379458 E-mail:
作者简介:

漆文霞(1995-),女,博士研究生,主要从事中西医结合防治风湿病的相关研究

Research status of autophagy in the pathogenesis of rheumatoid arthritis
Wen-xia QI1, Gang WANG2 , Yan-feng YAN3, Jie-xiang TIAN2, Tao WANG2, Yong WEI2, Zhan-dong WANG1, Yuan-yuan ZHANG2
Affiliations
  • 1.School of Traditional Chinese of Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Department of Rheumatology and Orthopedics, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730020, Gansu Province, China
  • 3.Department of Respiratory and Critical Care Medicine, Fourth Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou 730060, Gansu Province, China
出版时间: 2025-01-28 doi: 10.13699/j.cnki.1001-6821.2025.02.023
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随着分子生物学和细胞生物学研究的深入,自噬的调控机制被逐渐揭示,为众多疾病的治疗提供了新的思路。自噬可能与成纤维样滑膜细胞的凋亡抵抗、骨代谢平衡紊乱、抗原提呈等病理变化密切相关,调节自噬平衡可能是治疗类风湿关节炎(RA)的重要方法。本文就自噬在RA的病理机制做一综述,以期为后期的研究提供理论依据。

类风湿关节炎  /  自噬  /  病理机制  /  研究现状

With the deepening of molecular biology and cell biology research, the regulatory mechanism of autophagy has been gradually revealed, providing new ideas for the treatment of numerous diseases. Autophagy may be closely related to pathological changes such as apoptosis resistance of fibroblast-like synoviocytes, disturbances in bone metabolic homeostasis, and antigen presentation, the regulation of autophagy homeostasis may be an important approach for the treatment of rheumatoid arthritis (RA). In this paper, we provide a review on the pathological mechanism of autophagy in RA, with a view to providing a theoretical basis for later studies.

rheumatoid arthritis  /  autophagy  /  pathomechanism  /  research status
漆文霞, 王钢, 闫彦峰, 田杰祥, 王涛, 魏勇, 汪湛东, 张媛媛. 自噬在类风湿关节炎病理机制中的研究现状. 中国临床药理学杂志, 2025 , 41 (2) : 264 -268 . DOI: 10.13699/j.cnki.1001-6821.2025.02.023
Wen-xia QI, Gang WANG, Yan-feng YAN, Jie-xiang TIAN, Tao WANG, Yong WEI, Zhan-dong WANG, Yuan-yuan ZHANG. Research status of autophagy in the pathogenesis of rheumatoid arthritis[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (2) : 264 -268 . DOI: 10.13699/j.cnki.1001-6821.2025.02.023
  • 国家自然科学基金资助项目(81860858; 81960832)
  • 甘肃省科技基金资助项目(22JR11RA131)
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2025年第41卷第2期
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文章信息
doi: 10.13699/j.cnki.1001-6821.2025.02.023
  • 接收时间:2024-06-17
  • 首发时间:2026-08-04
  • 出版时间:2025-01-28
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出版历史
  • 收稿日期:2024-06-17
基金
国家自然科学基金资助项目(81860858; 81960832)
甘肃省科技基金资助项目(22JR11RA131)
作者信息
    1.甘肃中医药大学 中西医结合学院,甘肃 兰州 730000
    2.甘肃中医药大学 附属医院 风湿骨病科,甘肃 兰州 730020
    3.甘肃中医药大学 第四附属医院 呼吸与危重症医学科,甘肃 兰州 730060

通讯作者:

王钢,主任医师,博士生导师 MP: 18419379458 E-mail:
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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.02.023
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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