Article(id=1291339181809201204, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1724774400000, receivedDateStr=2024-08-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808852864, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808852864, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808852864, creator=13041195026, updateTime=1785808852864, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=422, endPage=427, ext={EN=ArticleExt(id=1291339182044082229, articleId=1291339181809201204, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of traditional Chinese medicine monomer components regulating TLR4/NF-κB signaling pathway in the treatment of liver cancer, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Toll-like receptor 4(TLR4)/ nuclear factor-κB (NF-κB) signaling pathway plays an important role in invasion, proliferation, migration, apoptosis and autophagy of hepatocellular carcinoma cells. Traditional Chinese medicine (TCM) monomers inhibit M2 macrophage polarization, epithelial-mesenchymal transformation (EMT), snail family transcriptional repressor 2 (SLUG) deubiquitination by ubiquitin-specific proteases (USP) and lipopolysaccharide (LPS) -induced cell damage by intervening TLR4/NF-κB signaling pathway. Serum inflammatory chemokine ligand 1(CXCL1) level and cyclooxygenase-2 (COX-2) protein level were significantly decreased and matrixmetalloprotease-9 (MMP-9) protein level was significantly decreased. The expression of MMP-9, decreased the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF), and interfered with mitochondrial membrane potential (MMP), thereby inhibiting tumor cell invasion and migration, and promoting autophagy and apoptosis of hepatoma cells. The main purpose of this review is to update the latest TCM monomer components that exert anti-liver cancer effect through TLR4/NF-κB signaling, and to clarify the main mechanism of their action on liver cancer, and to provide ideas and methods for exploring more TCM with anti-liver cancer properties, so as to better promote the further development and utilization of TCM resources.

, authors=Zong-bo ZHANG¹, Guo-jing MA², Wei-wang TUO¹, Jie HAI¹, Hong-juan YANG¹, Xu-dong TIAN³, authorsList=Zong-bo ZHANG, Guo-jing MA, Wei-wang TUO, Jie HAI, Hong-juan YANG, Xu-dong TIAN, authorCompany=null, correspAuthors=Xu-dong TIAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339182652256310, articleId=1291339181809201204, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药单体调控TLR4/NF-κB信号通路治疗肝癌的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

Toll样受体4（TLR4）/核转录因子-κB（NF-κB）信号通路，在肝癌细胞的侵袭、增殖、迁移、凋亡和自噬方面发挥重要的作用。中药单体成分通过干预TLR4/NF-κB信号通路抑制M2巨噬细胞极化、上皮-间质转化（EMT）、泛素特异性蛋白酶（USPs）对锌指转录因子（SLUG）的去泛素化和脂多糖（LPS）诱导的细胞损伤，显著降低血清炎症趋化因子配体1（CXCL1）水平和环氧合酶-2（COX-2）蛋白水平降低基质金属蛋白酶-9（MMP-9）的表达，降低粒细胞-巨噬细胞集落刺激因子（GM-CSF）和粒细胞集落刺激因子（G-CSF）的水平和干扰线粒体膜电位（MMP），从而抑制肿瘤细胞侵袭迁移，促进肝癌细胞自噬和凋亡。该综述的主要目的是更新通过TLR4/NF-κB信号发挥抗肝癌作用的最新中药单体成分，以及阐明其对肝癌的主要作用机制，同时为探索出更多具有抗肝癌特性的中药成提供思路和方法，更好地促进中药资源的进一步开发利用。

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张宗博（1997-），男，硕士研究生，主要从事中西医结合防治消化道疾病的研究

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张宗博（1997-），男，硕士研究生，主要从事中西医结合防治消化道疾病的研究

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