Article(id=1291339178738966538, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339021272211834, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.02.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1718208000000, receivedDateStr=2024-06-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808852132, onlineDateStr=2026-08-04, pubDate=1737993600000, pubDateStr=2025-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808852132, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808852132, creator=13041195026, updateTime=1785808852132, updator=13041195026, issue=Issue{id=1291339021272211834, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1737993600000', pubDateStr='2025-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808814590, creator='13041195026', updateTime=1785808814590, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=250, endPage=253, ext={EN=ArticleExt(id=1291339180890644491, articleId=1291339178738966538, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=New approved drug for the treatment of relapsed or refractory pediatric low-grade glioma——Tovorafenib, columnId=1291339032068354347, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=New Drugs Introduction, runingTitle=null, highlight=null, articleAbstract=

Tovorafenib has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients 6 months of age and older with relapsed or refractory pediatric low-grade glioma(LGGs) harboring the serine threonine kinae v-RAF murine sarcoma viral oncogene homologue B1 (BRAF) fusion or rearrangement, or BRA^V600E mutation. Tovorafenib is an oral, greater brain-penetrant, selective, type Ⅱ RAF inhibitor which has potent activity against both oncogenic BRAF fusions and BRAF^V600E mutations. Most tumors have been showed some degree of shrinkage. The mechanism of action, pharmacodynamics, pharmacokinetics, clinical study and safety were introduced.

, authors=Ting-ting BIAN^1a, Du-han BO^1b, Xin HE², Yan-ni CHEN², authorsList=Ting-ting BIAN, Du-han BO, Xin HE, Yan-ni CHEN, authorCompany=null, correspAuthors=Yan-ni CHEN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339182455119884, articleId=1291339178738966538, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=治疗复发或难治性儿童低级别胶质瘤的新药——Tovorafenib, columnId=1291339032219349293, journalTitle=中国临床药理学杂志, columnName=新药介绍, runingTitle=null, highlight=null, articleAbstract=

Tovorafenib是由美国食品药品监督管理局正式批准用于治疗6个月及以上儿童的复发或难治性低级别胶质瘤（LGGs），这些患者存在丝氨酸/苏氨酸激酶v-RAF鼠肉瘤病毒致癌基因同源物B1（BRAF）基因融合或BRAF^V600E基因突变。Tovorafenib是一款口服、较高脑渗透性、选择性Ⅱ型RAF激酶抑制药，可抑制BRAF基因融合、BRAF^V600E基因突变，大多数患者肿瘤显示出一定程度的缩小，现对其作用机制、药效学、药代动力学、临床研究及安全性等做一介绍。

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