Article(id=1291339140025537248, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339021272211834, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.02.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1719072000000, receivedDateStr=2024-06-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808842899, onlineDateStr=2026-08-04, pubDate=1737993600000, pubDateStr=2025-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808842899, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808842899, creator=13041195026, updateTime=1785808842899, updator=13041195026, issue=Issue{id=1291339021272211834, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1737993600000', pubDateStr='2025-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808814590, creator='13041195026', updateTime=1785808814590, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=193, endPage=197, ext={EN=ArticleExt(id=1291339140394636001, articleId=1291339140025537248, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of
miR-508-3
p involvement in ovarian cancer progression by regulating ZEB1, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the expression of microRNA-508-3p (miR-508-3p) in epithelial ovarian cancer (EOC) tissue, its impact on the migration and invasion of ovarian cancer cells, and its regulatory relationship with zinc-finger E-box-binding homeobox 1 (ZEB1).
Methods The surgical resection of EOC cancer tissues and paired adjacent normal tissues were collected. SKOV3 cells were divided into the NC mimic group (transfected with NC mimic), miR-508-3p mimic group (transfected with miR-508-3p mimic), si-NC group (transfected with si-NC), si-ZEB1 group (transfected with si-ZEB1) and co-transfection group (co-transfected with si-ZEB1 and miR-508-3p mimic). The mRNA expression levels of miR-508-3p and ZEB1 in EOC cancer tissues, adjacent normal tissues and five groups of cells were measured by real-time quantitative polymerase chain reaction. The Transwell assay was used to detect the cell migration and invasion abilities.
Results The relative expression levels of miR-508-3p in EOC tissues and adjacent normal tissues were 0.77±0.36 and 1.07±0.40, the relative expression levels of ZEB1 mRNA in EOC tissues and adjacent normal tissues were 2.10±1.21 and 1.29±0.95, and the differences were statistically significant (all P<0.01). The migration cell number of the NC mimic, miR-508-3p mimic, si-NC, si-ZEB1 and co-transfection groups was 633.00±32.49, 319.20±19.89, 650.40±25.85, 375.00±17.25 and 129.40±17.10; the invasion cell number was 527.20±25.01, 288.60±16.68, 520.00±25.83, 293.40±18.37 and 76.60±8.76; the relative expression levels of miR-508-3p were 1.05±0.37, 3.94±1.21, 1.01±0.21, 1.26±0.34 and 3.40±0.41; the relative expression levels of ZEB1 mRNA were 1.00±0.04, 0.58±0.05, 1.00±0.08, 0.54±0.07 and 0.29±0.03, respectively. The above indicators showed statistically significant differences between the miR-508-3p mimic group and the NC mimic group, between the si-NC group and the co-transfection group (P<0.01, P<0.05).
Conclusion MiR-508-3p is lowly expressed in EOC cancer tissue, and it may inhibit the migration and invasion of ovarian cancer cells by targeting ZEB1 expression.
, authors=Yu-hong XU, Shuai-ying ZHU, Jiang-jing SHAN, Wei-ping ZHENG, Hui-ya ZHANG, Yun-gen WANG, authorsList=Yu-hong XU, Shuai-ying ZHU, Jiang-jing SHAN, Wei-ping ZHENG, Hui-ya ZHANG, Yun-gen WANG, authorCompany=null, correspAuthors=Jiang-jing SHAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339140973449954, articleId=1291339140025537248, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=
miR-508-3
p通过调控ZEB1参与卵巢癌进展的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究微小RNA-508-3p（miR-508-3p）在上皮性卵巢癌（EOC）癌组织中的表达情况，对卵巢癌细胞迁移、侵袭能力的影响，及其与锌指E盒结合蛋白1（ZEB1）的调控关系。
方法 收集手术切除的EOC癌组织及配对的癌旁正常组织。将SKOV3细胞分为NC mimic组（转染NC mimic）、miR-508-3p mimic组（转染miR-508-3p mimic）、si-NC组（转染si-NC）、si-ZEB1组（转染si-ZEB1）和共转染组（共转染si-ZEB1和miR-508-3p mimic）。用实时荧光定量聚合酶链反应法检测EOC癌组织及癌旁正常组织与5组细胞中miR-508-3p和ZEB1 mRNA的表达水平，用Transwell实验法检测细胞的迁移、侵袭能力。
结果 EOC癌组织和癌旁正常组织中miR-508-3p相对表达水平分别为0.77±0.36和1.07±0.40，ZEB1 mRNA相对表达水平分别为2.10±1.21和1.29±0.95，在统计学上差异均有统计学意义（均P<0.01）。NC mimic组、miR-508-3p mimic组、si-NC组、si-ZEB1组和共转染组的迁移细胞数分别为（633.00±32.49）、（319.20±19.89）、（650.40±25.85）、（375.00±17.25）和（129.40±17.10）个，侵袭细胞数分别为（527.20±25.01）、（288.60±16.68）、（520.00±25.83）、（293.40±18.37）和（76.60±8.76）个，miR-508-3p相对表达水平分别为1.05±0.37、3.94±1.21、1.01±0.21、1.26±0.34和3.40±0.41，ZEB1 mRNA相对表达水平分别为1.00±0.04、0.58±0.05、1.00±0.08、0.54±0.07和0.29±0.03。miR-508-3p mimic组的上述指标与NC mimic组比较，si-ZEB1组的上述指标与共转染组比较，在统计学上差异均有统计学意义（P<0.01，P<0.05）。
结论 miR-508-3p在EOC癌组织中低表达，其可能通过靶控ZEB1表达，从而抑制卵巢癌细胞的迁移和侵袭。
, authors=徐玉红, 朱帅莹, 单江静, 郑伟平, 张慧雅, 王运根, authorsList=徐玉红, 朱帅莹, 单江静, 郑伟平, 张慧雅, 王运根, authorCompany=null, correspAuthors=单江静, authorNote=
徐玉红（1988-），女，副主任医师，主要从事妇科方向的临床诊疗工作
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=4AgUzxdqvXr9VJmSr0Koyw==, magXml=Bmkgs2LVXijWMFaFb5YNDQ==, pdfUrl=null, pdf=3p+6k5DMaMk5RxiJ3ZkeVg==, pdfFileSize=1737512, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=jhtMMqReCuDT2nW+l/9LpQ==, mapNumber=null, fund=null)}, authors=[Author(id=1291339141531292391, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339141682287337, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339141531292391, language=EN, stringName=Yu-hong XU, firstName=Yu-hong, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339141837476586, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339141531292391, language=CN, stringName=徐玉红, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=绍兴市人民医院 妇科，浙江 绍兴 312000, bio={"content":"
徐玉红（1988-），女，副主任医师，主要从事妇科方向的临床诊疗工作
"}, bioImg=null, bioContent=
徐玉红（1988-），女，副主任医师，主要从事妇科方向的临床诊疗工作
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339141401268963, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, xref=null, ext=[AuthorCompanyExt(id=1291339141409657572, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China), AuthorCompanyExt(id=1291339141422240485, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=绍兴市人民医院 妇科，浙江 绍兴 312000)])]), Author(id=1291339142013637356, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339142202381038, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339142013637356, language=EN, stringName=Shuai-ying ZHU, firstName=Shuai-ying, middleName=null, lastName=ZHU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339143993348847, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339142013637356, language=CN, stringName=朱帅莹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=绍兴市人民医院 妇科，浙江 绍兴 312000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339141401268963, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, xref=null, ext=[AuthorCompanyExt(id=1291339141409657572, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China), AuthorCompanyExt(id=1291339141422240485, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=绍兴市人民医院 妇科，浙江 绍兴 312000)])]), Author(id=1291339144211452657, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=sjj128@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291339144362447603, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339144211452657, language=EN, stringName=Jiang-jing SHAN, firstName=Jiang-jing, middleName=null, lastName=SHAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339144475693812, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339144211452657, language=CN, stringName=单江静, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=绍兴市人民医院 妇科，浙江 绍兴 312000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339141401268963, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, xref=null, ext=[AuthorCompanyExt(id=1291339141409657572, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China), AuthorCompanyExt(id=1291339141422240485, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=绍兴市人民医院 妇科，浙江 绍兴 312000)])]), Author(id=1291339144597328630, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339144706380536, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339144597328630, language=EN, stringName=Wei-ping ZHENG, firstName=Wei-ping, middleName=null, lastName=ZHENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339144777683705, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339144597328630, language=CN, stringName=郑伟平, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=绍兴市人民医院 妇科，浙江 绍兴 312000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339141401268963, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, xref=null, ext=[AuthorCompanyExt(id=1291339141409657572, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China), AuthorCompanyExt(id=1291339141422240485, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=绍兴市人民医院 妇科，浙江 绍兴 312000)])]), Author(id=1291339144848986875, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339144932872957, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339144848986875, language=EN, stringName=Hui-ya ZHANG, firstName=Hui-ya, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339145008370430, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339144848986875, language=CN, stringName=张慧雅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=绍兴市人民医院 妇科，浙江 绍兴 312000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339141401268963, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, xref=null, ext=[AuthorCompanyExt(id=1291339141409657572, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China), AuthorCompanyExt(id=1291339141422240485, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=绍兴市人民医院 妇科，浙江 绍兴 312000)])]), Author(id=1291339145222279936, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339145297777410, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339145222279936, language=EN, stringName=Yun-gen WANG, firstName=Yun-gen, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339145369080579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, authorId=1291339145222279936, language=CN, stringName=王运根, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=绍兴市人民医院 妇科，浙江 绍兴 312000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339141401268963, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, xref=null, ext=[AuthorCompanyExt(id=1291339141409657572, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China), AuthorCompanyExt(id=1291339141422240485, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=绍兴市人民医院 妇科，浙江 绍兴 312000)])])], keywords=[Keyword(id=1291339145507492612, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=EN, orderNo=1, keyword=microRNA-508-3p), Keyword(id=1291339145566212869, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=EN, orderNo=2, keyword=zinc-finger E-box-binding homeobox 1), Keyword(id=1291339145645904646, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=EN, orderNo=3, keyword=epithelial ovarian cancer), Keyword(id=1291339145742373639, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=EN, orderNo=4, keyword=migration), Keyword(id=1291339145834648328, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=EN, orderNo=5, keyword=invasion), Keyword(id=1291339145910145801, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=CN, orderNo=1, keyword=微小RNA-508-3p), Keyword(id=1291339145973060362, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=CN, orderNo=2, keyword=锌指E盒结合蛋白1), Keyword(id=1291339146035974923, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=CN, orderNo=3, keyword=上皮性卵巢癌), Keyword(id=1291339146103083788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=CN, orderNo=4, keyword=迁移), Keyword(id=1291339146199552781, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, language=CN, orderNo=5, keyword=侵袭)], refs=null, funds=[Fund(id=1291339146287633166, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, awardId=2023KY1250; 2023KY362, language=CN, fundingSource=浙江省医药卫生科技计划基金资助项目(2023KY1250; 2023KY362), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291339141401268963, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, xref=null, ext=[AuthorCompanyExt(id=1291339141409657572, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Gynecology, Shaoxing People’s Hospital, Shaoxing 312000, Zhejiang Province, China), AuthorCompanyExt(id=1291339141422240485, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339140025537248, companyId=1291339141401268963, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=绍兴市人民医院 妇科，浙江 绍兴 312000)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.02.009, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.02.009, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.02.009, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.02.009, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1737993600000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
4
1
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
