Article(id=1291339104076157514, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339021272211834, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.02.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1721145600000, receivedDateStr=2024-07-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808834332, onlineDateStr=2026-08-04, pubDate=1737993600000, pubDateStr=2025-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808834332, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808834332, creator=13041195026, updateTime=1785808834332, updator=13041195026, issue=Issue{id=1291339021272211834, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1737993600000', pubDateStr='2025-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808814590, creator='13041195026', updateTime=1785808814590, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=178, endPage=182, ext={EN=ArticleExt(id=1291339104306844235, articleId=1291339104076157514, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of bevacizumab combined with paclitaxel and carboplatin in the treatment of patients with advanced ovarian cancer, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the long-term survival benefit status of bevacizumab injection combined with chemotherapy in the treatment of advanced ovarian cancer.
Methods The patients with advanced ovarian cancer were classified into control group and treatment group according to cohort method. The control group was treated with 175 mg·m-2 of paclitaxel injection + area under curve (AUC) 5 intravenous infusion of carboplatin injection once every 3 weeks for 6 cycles, and on the basis of the control group, the treatment group was additionally given intravenous injection of 15 mg·kg-1 of bevacizumab injection in the second cycle, once every 3 weeks, maintained monotherapy after 6 cycles until disease progression (up to 22 cycles of treatment). The solid tumor efficacy at 6 cycles of treatment and levels of serum tumor markers [carbohydrate antigen (CA) 125, CA199, human epididymis protein 4 (HE4)], vascular endothelial growth factor (VEGF), macrophage migration inhibitory factor (MIF), long term survival status (overall survival time, progression-free survival time) and safety evaluation before treatment and at 6 cycles of treatment were compared.
Results There were 51 cases in the control group and 31 cases in the treatment group. After 6 cycles of treatment, the total effective rates of the treatment group and the control group was 77.42% (24 cases/31 cases) and 52.94% (27 cases/51 cases), respectively, and the difference was statistically significant (P<0.05). After 6 cycles of treatment, serum CA125 levels in treatment group and control group were (63.71±8.53) and (73.09±9.55) U·mL-1; the CA199 levels were (58.97±10.87) and (69.39±12.45) U·mL-1; the HE4 levels were (117.96±22.73) and (155.60±30.92) pmol·L-1; levels of VEGF were (285.50±60.42) and (377.82±73.31) ng·L-1; the levels of MIF were (20.26±3.42) and (22.34±3.19) μg·L-1, the progression-free survival time was 7 (0, 17) and 2 (0, 6) months; there were statistically significant differences in the above indexes between the treatment group and the control group(P<0.05, P<0.01, P<0.001). The overall survival time in treatment group and control group was 10 (6, 20) months and 8 (4, 11) months. The differences were statistically significant(P>0.05). The adverse drug reactions in treatment group were mainly nausea and vomiting, hypertension and bone marrow suppression while the adverse drug reactions in control group were mainly nausea and vomiting and bone marrow suppression, and the total incidences of adverse drug reactions were 45.16% (14 cases/31 cases) and 35.29% (18 cases/51 cases) respectively (P>0.05).
Conclusion Bevacizumab injection combined with chemotherapy has good clinical efficacy in the treatment of advanced ovarian cancer, and significantly prolong the progression-free survival time of patients.
, authors=Li XU, authorsList=Li XU, authorCompany=null, correspAuthors=Li XU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339104717886028, articleId=1291339104076157514, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=贝伐珠单抗联合紫杉醇和卡铂治疗晚期卵巢癌患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察贝伐珠单抗注射液联合紫杉醇注射液和卡铂注射液对晚期卵巢癌患者远期生存获益的影响。
方法 将晚期卵巢癌患者根据队列法分为对照组和试验组。对照组给予紫杉醇注射液175 mg·m-2+卡铂注射液药时曲线下面积（AUC）5静脉滴注治疗，每3周1次，治疗6个周期；试验组在对照组治疗的基础上，于第二周期加用贝伐珠单抗注射液15 mg·kg-1静脉注射，每3周1次，治疗6个周期后维持单药治疗至疾病进展，最多治疗22个周期。比较2组患者治疗6个周期后的实体瘤疗效，血清肿瘤标志物水平[糖类抗原（CA）125、CA199、人附睾蛋白4（HE4）]、血管内皮生长因子（VEGF）、巨噬细胞移动抑制因子（MIF）水平，远期生存情况[总生存期、无进展生存期]，以及安全性评价。
结果 对照组入组51例，试验组入组31例。治疗6个周期后，试验组和对照组的总有效率分别为77.42%（24例/31例）和52.94%（27例/51例），在统计学上差异有统计学意义（P<0.05）。治疗6个周期后，试验组和对照组血清CA125水平分别为（63.71±8.53）和（73.09±9.55）U·mL-1，CA199水平分别为（58.97±10.87）和（69.39±12.45）U·mL-1，HE4水平分别为（117.96±22.73）和（155.60±30.92）pmol·L-1，VEGF水平分别为（285.50±60.42）和（377.82±73.31）ng·L-1，MIF水平分别为（20.26±3.42）和（22.34±3.19）μg·L-1，无进展生存期分别为7（0，17）和2（0，6）个月，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）。试验组和对照组的总生存期分别为10（6，20）和8（4，11）个月，在统计学上差异无统计学意义（P>0.05）。试验组发生的药物不良反应主要有恶心呕吐、高血压、骨髓抑制，对照组发生的药物不良反应主要有恶心呕吐、骨髓抑制。试验组和对照组的总药物不良反应发生率分别为45.16%（14例/31例）和35.29%（18例/51例），在统计学上差异无统计学意义（P<0.05）。
结论 贝伐珠单抗注射液联合紫杉醇注射液和卡铂注射液治疗晚期卵巢癌患者的临床疗效较好，能够显著延长患者的无进展生存期。
, authors=徐丽, authorsList=徐丽, authorCompany=null, correspAuthors=徐丽, authorNote=
徐丽（1973-），女，副主任医师，主要从事妇科方面的临床诊疗工作
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徐丽（1973-），女，副主任医师，主要从事妇科方面的临床诊疗工作
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徐丽（1973-），女，副主任医师，主要从事妇科方面的临床诊疗工作
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