Article(id=1291339082450334315, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.026, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1722960000000, receivedDateStr=2024-08-07, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808829176, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808829176, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808829176, creator=13041195026, updateTime=1785808829176, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=428, endPage=432, ext={EN=ArticleExt(id=1291339082949456492, articleId=1291339082450334315, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Status in the application of Saccharomyces boulardii versus in the treatment of pediatric diarrhea, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Saccharomyces boulardii (S. boulardii), as the sole fungal probiotic, exhibits significant therapeutic efficacy in treating various gastrointestinal disorders. In contrast to traditional bacterial probiotic preparations, S. boulardii stands out for its diverse array of biological activities, including anti-inflammatory, antibacterial, enzymatic, metabolic, and anti-toxin properties. S. boulardii is not indigenous to the human microbiome and is resistant to gastric acid, ensuring its stability and tolerability. Clinical research indicates that S. boulardii offers a positive therapeutic effect in treating gastrointestinal disorders such as acute diarrhea, antibiotic-induced diarrhea, inflammatory bowel disease, and irritable bowel syndrome, while also demonstrating high oral safety. Although the specific mechanisms of action of S. boulardii remain unclear, its clinical efficacy has been widely recognized. This article provides an overview of the advancements in S. boulardii’s application in treating childhood gastrointestinal diseases, serving as a reference for future research directions and clinical applications of this fungus.

, authors=Li-li MOU^1a, Jian-zhao CHEN^1a, Mei ZHUANG^1a, Jin-lian XUE^1b, Lan-lan CHEN^1b, Ying YANG^1b, Yong LIU^1c, Mei-xing YAN², authorsList=Li-li MOU, Jian-zhao CHEN, Mei ZHUANG, Jin-lian XUE, Lan-lan CHEN, Ying YANG, Yong LIU, Mei-xing YAN, authorCompany=null, correspAuthors=Mei-xing YAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339084912390765, articleId=1291339082450334315, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=布拉氏酵母菌在治疗儿童胃肠道疾病的应用现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

布拉氏酵母菌作为唯一一种真菌类益生菌，在治疗多种胃肠道疾病方面疗效显著。与传统的细菌类益生菌制剂不同，布拉氏酵母菌以其抗炎、抗菌、酶促、代谢和抗毒素等多种生物活性而备受关注。布拉氏酵母菌不属于人体原籍菌，不易被胃酸破坏，具有良好的稳定性和耐受作用。临床研究表明，布拉氏酵母菌对于急性腹泻、抗菌药物相关性腹泻、炎症性肠病以及肠易激综合征等胃肠道疾病具有积极的治疗效果，并且具有较高的口服安全性。尽管布拉氏酵母菌的具体作用机制尚未完全明确，但其在临床上的治疗效果已得到了广泛认可。本文综述了布拉氏酵母菌在治疗儿童胃肠道疾病的应用进展，为未来布拉氏酵母菌的研究方向和临床应用提供参考。

, authors=牟丽莉^1a, 陈剑钊^1a, 庄梅^1a, 薛金莲^1b, 陈兰兰^1b, 杨颖^1b, 刘勇^1c, 闫美兴², authorsList=牟丽莉, 陈剑钊, 庄梅, 薛金莲, 陈兰兰, 杨颖, 刘勇, 闫美兴, authorCompany=null, correspAuthors=闫美兴, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=r3x1cdH3ayhFbYpE74UAGA==, magXml=gxwylcyKArfLplYVEHeOfA==, pdfUrl=null, pdf=RZmnEx5o6klrIPIb2oBILA==, pdfFileSize=1348864, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=JJRxn8RJMYf+XxlyS5GfCQ==, mapNumber=null, fund=null)}, authors=[Author(id=1291339087382835835, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339087785489021, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339087382835835, language=EN, stringName=Li-li MOU, firstName=Li-li, middleName=null, lastName=MOU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339088200725118, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339087382835835, language=CN, stringName=牟丽莉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.日照市中心医院，药学部，山东，日照 276800, bio={"content":"

牟丽莉（1985-），女，主管药师，主要从事临床药学方面的工作

"}, bioImg=null, bioContent=

牟丽莉（1985-），女，主管药师，主要从事临床药学方面的工作

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339085851914862, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1a., ext=[AuthorCompanyExt(id=1291339085860303471, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085851914862, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339085868692080, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085851914862, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.日照市中心医院，药学部，山东，日照 276800)])]), Author(id=1291339088288805504, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339088666292866, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339088288805504, language=EN, stringName=Jian-zhao CHEN, firstName=Jian-zhao, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339090306265731, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339088288805504, language=CN, stringName=陈剑钊, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.日照市中心医院，药学部，山东，日照 276800, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339085851914862, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1a., ext=[AuthorCompanyExt(id=1291339085860303471, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085851914862, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339085868692080, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085851914862, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.日照市中心医院，药学部，山东，日照 276800)])]), Author(id=1291339090377568901, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339090490815111, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339090377568901, language=EN, stringName=Mei ZHUANG, firstName=Mei, middleName=null, lastName=ZHUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339090549535368, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339090377568901, language=CN, stringName=庄梅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.日照市中心医院，药学部，山东，日照 276800, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339085851914862, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1a., ext=[AuthorCompanyExt(id=1291339085860303471, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085851914862, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339085868692080, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085851914862, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.日照市中心医院，药学部，山东，日照 276800)])]), Author(id=1291339090784416394, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339090872496780, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339090784416394, language=EN, stringName=Jin-lian XUE, firstName=Jin-lian, middleName=null, lastName=XUE, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339090943799949, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339090784416394, language=CN, stringName=薛金莲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.日照市中心医院，儿科，山东，日照 276800, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339085919023729, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1b., ext=[AuthorCompanyExt(id=1291339086111961714, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085919023729, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339086120350323, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085919023729, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.日照市中心医院，儿科，山东，日照 276800)])]), Author(id=1291339091220624015, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339091577139857, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339091220624015, language=EN, stringName=Lan-lan CHEN, firstName=Lan-lan, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339091983987346, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339091220624015, language=CN, stringName=陈兰兰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.日照市中心医院，儿科，山东，日照 276800, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339085919023729, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1b., ext=[AuthorCompanyExt(id=1291339086111961714, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085919023729, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339086120350323, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085919023729, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.日照市中心医院，儿科，山东，日照 276800)])]), Author(id=1291339092051096212, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339092130787990, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339092051096212, language=EN, stringName=Ying YANG, firstName=Ying, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339092483109527, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339092051096212, language=CN, stringName=杨颖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.日照市中心医院，儿科，山东，日照 276800, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339085919023729, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1b., ext=[AuthorCompanyExt(id=1291339086111961714, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085919023729, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339086120350323, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085919023729, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.日照市中心医院，儿科，山东，日照 276800)])]), Author(id=1291339092541829785, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339092625715867, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339092541829785, language=EN, stringName=Yong LIU, firstName=Yong, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1c, address=^1c.Department of Otolaryngology, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339092705407644, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339092541829785, language=CN, stringName=刘勇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1c, address=^1c.日照市中心医院，耳鼻喉科，山东，日照 276800, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339086527197812, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1c., ext=[AuthorCompanyExt(id=1291339086535586421, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339086527197812, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1c.Department of Otolaryngology, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339086548169334, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339086527197812, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1c.日照市中心医院，耳鼻喉科，山东，日照 276800)])]), Author(id=1291339092785099422, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=meixing@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291339092852208288, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339092785099422, language=EN, stringName=Mei-xing YAN, firstName=Mei-xing, middleName=null, lastName=YAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.Department of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao 266034, Shandong Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339094508958369, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, authorId=1291339092785099422, language=CN, stringName=闫美兴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=^2.青岛妇女儿童医院 药学部，山东 青岛 266034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339087017931383, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=2., ext=[AuthorCompanyExt(id=1291339087026319992, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339087017931383, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Department of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao 266034, Shandong Province, China), AuthorCompanyExt(id=1291339087038902905, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339087017931383, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.青岛妇女儿童医院 药学部，山东 青岛 266034)])])], keywords=[Keyword(id=1291339094634787490, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, language=EN, orderNo=1, keyword=Saccharomyces boulardii), Keyword(id=1291339094706090659, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, language=EN, orderNo=2, keyword=pediatric diarrhea), Keyword(id=1291339094785782436, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, language=EN, orderNo=3, keyword=gastrointestinal disease), Keyword(id=1291339094857085605, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, language=EN, orderNo=4, keyword=clinical research), Keyword(id=1291339094924194470, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, language=CN, orderNo=1, keyword=布拉氏酵母菌), Keyword(id=1291339094987109031, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, language=CN, orderNo=2, keyword=儿童腹泻), Keyword(id=1291339095058412200, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, language=CN, orderNo=3, keyword=胃肠道疾病), Keyword(id=1291339095159075497, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, language=CN, orderNo=4, keyword=临床研究)], refs=null, funds=[Fund(id=1291339095242961578, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, awardId=SDSYXH-KY-202208, language=CN, fundingSource=山东省药学会科研基金资助项目(SDSYXH-KY-202208), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1291339085851914862, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1a., ext=[AuthorCompanyExt(id=1291339085860303471, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085851914862, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.Department of Pharmacy, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339085868692080, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085851914862, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.日照市中心医院，药学部，山东，日照 276800)]), AuthorCompany(id=1291339085919023729, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1b., ext=[AuthorCompanyExt(id=1291339086111961714, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085919023729, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.Department of Pediatrics, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339086120350323, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339085919023729, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.日照市中心医院，儿科，山东，日照 276800)]), AuthorCompany(id=1291339086527197812, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=1c., ext=[AuthorCompanyExt(id=1291339086535586421, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339086527197812, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1c.Department of Otolaryngology, Rizhao Central Hospital, Rizhao 276800, Shandong Province, China), AuthorCompanyExt(id=1291339086548169334, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339086527197812, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1c.日照市中心医院，耳鼻喉科，山东，日照 276800)]), AuthorCompany(id=1291339087017931383, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, xref=2., ext=[AuthorCompanyExt(id=1291339087026319992, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339087017931383, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Department of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao 266034, Shandong Province, China), AuthorCompanyExt(id=1291339087038902905, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339082450334315, companyId=1291339087017931383, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.青岛妇女儿童医院 药学部，山东 青岛 266034)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.03.026, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.03.026, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.03.026, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.03.026, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1739721600000, fullTextJson=null, articleText=null, reference=null)