Article(id=1291339073482908360, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339021272211834, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.02.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1721923200000, receivedDateStr=2024-07-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808827038, onlineDateStr=2026-08-04, pubDate=1737993600000, pubDateStr=2025-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808827038, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808827038, creator=13041195026, updateTime=1785808827038, updator=13041195026, issue=Issue{id=1291339021272211834, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1737993600000', pubDateStr='2025-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808814590, creator='13041195026', updateTime=1785808814590, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=230, endPage=234, ext={EN=ArticleExt(id=1291339073650680521, articleId=1291339073482908360, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Determination of sotagliflozin in rat plasma by UPLC-MS/MS method, columnId=1246531413395263850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Research Method, runingTitle=null, highlight=null, articleAbstract=
Objective To establish a ultra-high performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS) method for determining the concentration of sotagliflozin in rat plasma and apply it to pharmacokinetic studies in rats.
Methods Electrospray negative ion multi-reaction ion detection was used. Chromatographic column: EXT-C18 (2.1 mm×100.0 mm, 2.7 μm); column temperature: 45 ℃; mobile phase: 5 mmol·L-1 ammonium acetate aqueous solution-acetonitrile; flow rate: 0.35 mL·min-1; ion pairs: sotagliflozin m/z 483.3→315.1, dapagliflozin m/z 467.4→329.2; injection volume: 6 μL, plasma samples were processed using methyl tert-butyl ether liquid-liquid extraction. Six male SD rats were administered a single oral dose of sogliflozin at 40 mg·kg-1, and detected the concentration of sogliflozin in plasma. Pharmacokinetic parameters were calculated using Drug And Statistics (DAS) 2.1.1.
Results Sotagliflozin showed good linearity within the range of 5-2 000 ng·mL-1, with intra-day and inter-day precision both less than 15%. The recovery rate, matrix effect, and stability were all within the specified range. Pharmacokinetic parameters: Cmax was (3 716.67±568.28) ng·mL-1, tmax was (1.00±0.32) h, t1/2 was (2.28±0.45) h, AUC0-t was (1.70×104±2 075.87) ng·mL-1·h.
Conclusion This study established a method for determining the concentration of sotagliflozin in rat plasma, which is characterized by high sensitivity, rapid detection, and good repeatability. It is suitable for the determination of sotagliflozin concentration in plasma and pharmacokinetic studies.
, authors=Ge-xi CAO
1, 2a, Xiao-xu ZHANG
2b, Yan-ru DENG
1, 2a, Bin YAN
1, 2a, Zhan-jun DONG
2a, 2c, authorsList=Ge-xi CAO, Xiao-xu ZHANG, Yan-ru DENG, Bin YAN, Zhan-jun DONG, authorCompany=null, correspAuthors=Zhan-jun DONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339074007196362, articleId=1291339073482908360, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=用UPLC-MS/MS法测定大鼠血浆中索格列净的浓度, columnId=1246531413600784769, journalTitle=中国临床药理学杂志, columnName=研究方法, runingTitle=null, highlight=null, articleAbstract=
目的 建立高效液相色谱串联质谱（UPLC-MS/MS）法，测定大鼠血浆中索格列净浓度，并应用于大鼠体内的药代动力学研究。
方法 电喷雾负离子方式多反应离子检测；色谱柱：EXT-C18柱（2.1 mm×100.0 mm，2.7 μm）；柱温：45 ℃；流动相：含5 mmol·L-1乙酸铵水-乙腈；流速：0.35 mL·min-1；索格列净离子对：m/z 483.3→315.1；达格列净离子对：m/z 467.4→329.2；进样量：6 μL，用甲基叔丁基醚液液萃取法处理血浆样品。将6只SD雄性大鼠单次灌胃索格列净40 mg·kg-1，检测血浆中索格列净的浓度，用Drug And Statistics（DAS）2.1.1软件计算药代动力学参数。
结果 索格列净在5~2 000 ng·mL-1内线性关系良好，日内和日间精密度均小于15%，回收率、基质效应与稳定性均在规定范围；药代动力学参数：Cmax为（3 716.67±568.28）ng·mL-1，tmax为（1.00±0.32）h，t1/2为（2.28±0.45）h，AUC0-t为（1.70×104±2 075.87）ng·mL-1·h。
结论 本研究建立了大鼠血浆中索格列净浓度的测定方法，具有灵敏度高、检测快速、重复性良好等特点，适用于血浆中索格列净浓度测定及药代动力学等研究。
, authors=曹格溪
1, 2a, 张晓旭
2b, 邓艳茹
1, 2a, 闫彬
1, 2a, 董占军
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曹格溪（1989-），女，硕士研究生，主管药师，主要从事临床药学方面的相关研究
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1.Graduate School, Hebei Medical University, Shijiazhuang 050051, Hebei Province, China
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1.河北医科大学 研究生学院，河北 石家庄 050051
2a.河北省人民医院，药学部，河北 石家庄 050051, bio={"content":"
曹格溪（1989-），女，硕士研究生，主管药师，主要从事临床药学方面的相关研究
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2b.Department of Acupuncture and Moxibustion, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339076750271201, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, authorId=1291339075005440734, language=CN, stringName=张晓旭, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2b.河北省人民医院，针灸科，河北 石家庄 050051, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339074468569809, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, xref=2b., ext=[AuthorCompanyExt(id=1291339074476958418, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, companyId=1291339074468569809, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2b.河北省人民医院，针灸科，河北 石家庄 050051)])]), Author(id=1291339076821574371, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339076909654758, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, authorId=1291339076821574371, language=EN, stringName=Yan-ru DENG, firstName=Yan-ru, middleName=null, lastName=DENG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2a, address=
1.Graduate School, Hebei Medical University, Shijiazhuang 050051, Hebei Province, China
2a.Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339076985152231, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, authorId=1291339076821574371, language=CN, stringName=邓艳茹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
1, 2a, address=
1.河北医科大学 研究生学院，河北 石家庄 050051
2a.河北省人民医院，药学部，河北 石家庄 050051, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339074275631819, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, xref=1., ext=[AuthorCompanyExt(id=1291339074288214732, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, companyId=1291339074275631819, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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1, 2a, address=
1.Graduate School, Hebei Medical University, Shijiazhuang 050051, Hebei Province, China
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1, 2a, address=
1.河北医科大学 研究生学院，河北 石家庄 050051
2a.河北省人民医院，药学部，河北 石家庄 050051, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339074275631819, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, xref=1., ext=[AuthorCompanyExt(id=1291339074288214732, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, companyId=1291339074275631819, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2a, 2c, address=
2a.Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
2c.Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339077517828851, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, authorId=1291339077371028207, language=CN, stringName=董占军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
2a, 2c, address=
2a.河北省人民医院，药学部，河北 石家庄 050051
2c.河北省人民医院，河北省临床药学重点实验室，河北 石家庄 050051, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339074372100814, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, xref=2a., ext=[AuthorCompanyExt(id=1291339074380489423, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339073482908360, companyId=1291339074372100814, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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