Article(id=1291339007661699178, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1719072000000, receivedDateStr=2024-06-23, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808811344, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808811344, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808811344, creator=13041195026, updateTime=1785808811344, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=6, endPage=10, ext={EN=ArticleExt(id=1291339007888191595, articleId=1291339007661699178, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trail of vericiguat combined with sacubitril valsartan sodium in the treatment of patients with heart failure with reduced ejection fraction, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of vericiguat tablets combined with sacubitril valsartan sodium (Sac/Val) tablets in the treatment of patients with heart failure with reduced ejection fraction (HFrEF).
Methods The HFrEF patients were divided into control group and treatment group according to the cohort method. The control group was treated with Sac/Val tablets 200 mg per time, bid, orally. On the basis of control group, the treatment group was treated with vericiguat tablets 2.5 mg per time, qd, taken with meal. Two groups were treated for 3 months. The clinical efficacy, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD) and end-systolic diameter (LVESD), levels of high sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), nitric oxide (NO), N-terminal pro-brain natriuretic peptide (NT-proBNP), blood urea nitrogen (BUN) and serum creatinine (SCr), and safety were compared between the two groups. During follow-up, the heart failure rehospitalization rates and major adverse cardiovascular events were compared between the two groups.
Results Treatment group was enrolled 53 patients, control group was enrolled 53 patients. After treatment, the total effective rates of treatment and control groups were 94.34% (50 cases / 53 cases) and 81.13% (43 cases / 53 cases) with statistical significant difference (P<0.05). After treatment, the LVEF of treatment and control groups were (48.02±5.20)% and (43.02±4.33)%, the LVEDDs were (52.85±6.30) and (55.63±6.88) mm, the LVESDs were (41.64±6.40) and (44.22±5.85) mm, the levels of hs-CRP were (10.22±2.63) and (14.60±2.98) mg·L-1, the levels of IL-6 were (14.48±2.40) and (17.36±2.52) pg·mL-1, the levels of NO were (102.60±20.16) and (92.16±16.33) μmol·L-1, the levels of NT-proBNP were (898.74±102.20) and (1315.60±182.64) ng·L-1, the levels of BUN were (12.02±2.28) and (13.45±2.33) mmol·L-1, the levels of SCr were (82.22±5.89) and (85.64±6.03) μmol·L-1, the heart failure rehospitalization rates were 5.66% and 13.21%, respectively; the differences were statistical significant between two groups (all P<0.05). The adverse drug reactions of treatment group were hyperkalemia, hypotension, renal dysfunction, dizziness and headache, while those in control group were renal dysfunction, hyperkalemia, and hypotension. The major adverse cardiovascular events of treatment group were angina pectoris and acute myocardial infarction, while those in control group were angina pectoris, acute myocardial infarction and atrial fibrillation. The incidences of total adverse drug reactions in treatment and control groups were 13.21% and 7.55%, the incidences of major adverse cardiovascular events were 5.66% and 13.21%, respectively, without statistically significant differences (all P>0.05).
Conclusion Vericiguat tablets combined with Sac/Val tablets have a definitive clinical efficacy in the treatment of HFrEF patients, which can improve cardiac and endothelial function, reduce inflammatory response and readmission times, without increasing the incidences of adverse drug reactions.
, authors=Miao-jun WANG, Shi-ping XU, Xiao-jin PAN, Zhi-dong YE, Yu-fang LIAN, Jun QIU, Shao-tang LU, Sheng-jie ZHOU, authorsList=Miao-jun WANG, Shi-ping XU, Xiao-jin PAN, Zhi-dong YE, Yu-fang LIAN, Jun QIU, Shao-tang LU, Sheng-jie ZHOU, authorCompany=null, correspAuthors=Sheng-jie ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339008605417580, articleId=1291339007661699178, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=维立西呱联合沙库巴曲缬沙坦钠治疗射血分数降低型心力衰竭患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察维立西呱片联合沙库巴曲缬沙坦钠（Sac/Val）片治疗射血分数降低型心力衰竭（HFrEF）患者的临床疗效及安全性。
方法 将HFrEF患者按队列法分为对照组和试验组。对照组给予Sac/Val片，每次200 mg，bid，口服；试验组在对照组治疗的基础上，给予维立西呱片，每次2.5 mg，qd，与餐同服。2组患者均治疗3个月。比较2组患者的临床疗效、左心室射血分数（LVEF），左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、超敏C-反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、一氧化氮（NO）、N-末端脑钠肽前体（NT-proBNP）、尿素氮（BUN）和肌酸酐（SCr）水平，以及安全性，并比较2组患者随访期间心力衰竭再住院率和主要不良心血管事件发生率。
结果 试验组和对照组各入组53例。治疗后，试验组和对照组的总有效率分别为94.34%（50例/53例）和81.13%（43例/53例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的LVEF分别为（48.02±5.20）%和（43.02±4.33）%，LVEDD分别为（52.85±6.30）和（55.63±6.88）mm，LVESD分别为（41.64±6.40）和（44.22±5.85）mm，hs-CRP水平分别为（10.22±2.63）和（14.60±2.98）mg·L-1，IL-6水平分别为（14.48±2.40）和（17.36±2.52）pg·mL-1，NO水平分别为（102.60±20.16）和（92.16±16.33）μmol·L-1，NT-proBNP水平分别为（898.74±102.20）和（1 315.60±182.64）ng·L-1，BUN水平分别为（12.02±2.28）和（13.45±2.33）mmol·L-1，SCr水平分别为（82.22±5.89）和（85.64±6.03）μmol·L-1，因心力衰竭再入院率分别为5.66%和13.21%，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要有高钾血症、低血压、肾功能损害、眩晕和头痛，对照组的药物不良反应主要有肾功能损害、高钾血症和低血压。试验组的不良心血管事件主要有心绞痛和急性心肌梗死，对照组的不良心血管事件主要有心绞痛、急性心肌梗死和心房颤动。试验组和对照组的总药物不良反应发生率分别为13.21%和7.55%，主要不良心血管事件发生率分别为5.66%和13.21%，在统计学上差异均无统计学意义（均P>0.05）。
结论 维立西呱片联合Sac/Val片治疗HFrEF患者的临床疗效显著，其能改善患者的心功能和血管内皮功能，减轻炎症反应，减少再入院次数，且不增加药物不良反应的发生率。
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王妙君（1985-），女，主治医师，主要从事高血压及心力衰竭方向的临床诊疗工作
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