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Article(id=1291339000166477841, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1714060800000, receivedDateStr=2024-04-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808809558, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808809558, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808809558, creator=13041195026, updateTime=1785808809558, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1, endPage=5, ext={EN=ArticleExt(id=1291339000627851282, articleId=1291339000166477841, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of budesonide and formoterol fumarate powder for inhalation in the treatment of elderly patients with cough variant asthma, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To compare the effects of different doses of budesonide and formoterol fumarate powder for inhalation combined with montelukast sodium tablet in the treatment of cough variant asthma (CVA) and the improvement of airway function and inflammatory factors.

Methods

Elderly patients with cough variant asthma were randomly divided into group A and group B. Both groups of patients received budesonide and formoterol fumarate powder for inhalation combined with montelukast sodium tablet. Group A was given budesonide and formoterol fumarate powder for inhalation(Ⅱ), 2 inhalation per time, twice a day; Group B was given budesonide and formoterol fumarate powder for inhalation, 4 inhalation per time, twice a day; budesonide fumatrol inhalation powder mist for continuous treatment for 6 months, and montelukast sodium tablet 10 mg once a day for at least 3 months. The nighttime cough scores of the two groups were compared before treatment and after treatment. The percentage of forced expiratory volume in one second (FEV1) in the predicted value, the maximum mid expiratory flow (MMEF), the fractional exhaled nitric oxide (FeNO), interleukin-5 (IL-5) and eosinophils were compared between the two groups. The incidence of adverse drug reactions and the recurrence rate within 1 year were compared between the two groups.

Results

A total of 45 cases were enrolled in both the group A and the group B. At 9 months after treatment, the nocturnal cough scores of the group A and the group B were (0.93±0.42) and (0.65±0.29) points, respectively; the percentage of FEV1 in the predicted value were (97.75±9.67)% and (100.93±11.06)%, respectively; the MMEF values were (2.81±1.04) and (3.08±1.09) L·s-1, respectively; the FeNO values were (18.94±9.75) and (15.94±7.96) ppb, respectively; the IL-5 levels were (10.88±7.06) and (8.11±5.56) pg·mL-1, respectively. The above indicators in group B showed statistically significant differences compared to group A (all P<0.05). The total incidence of adverse drug reactions in group A and group B were 8.89% (5 cases/45 cases) and 13.33% (6 cases/45 cases), respectively. The recurrence rates was 15.56% (7 cases/45 cases) and 13.33% (6 cases/45 cases), respectively. There was no statistically significant difference in the above indicators between group B and group A (all P>0.05).

Conclusion

For elderly patients with CVA, higher dose of budesonide and formoterol fumarate powder for inhalation combined with montelukast sodium tablet can better improve cough symptoms, reduce the level of airway hyperresponsiveness and inflammatory factors, reduce the recurrence rate, and the patients are well tolerated.

, authors=Ying SUN1a, Xin SONG1a, Jia WANG1a, Yan-fang HOU1b, Qun FU1a, Qi ZHANG1a, Jie LAI1a, Tao GENG1a, Chang-xin LI1a, Jia-hui HUO1a, Ying ZHANG2, Yan WENG1c, authorsList=Ying SUN, Xin SONG, Jia WANG, Yan-fang HOU, Qun FU, Qi ZHANG, Jie LAI, Tao GENG, Chang-xin LI, Jia-hui HUO, Ying ZHANG, Yan WENG, authorCompany=null, correspAuthors=Yan WENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339001806450707, articleId=1291339000166477841, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=布地奈德福莫特罗吸入粉雾剂治疗老年咳嗽变异性哮喘患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

比较不同剂量的布地奈德福莫特罗吸入粉雾剂（Ⅱ）联合孟鲁司特钠片治疗咳嗽变异性哮喘（CVA）患者的效果及对气道功能、炎症因子的改善情况。

方法

将老年CVA患者随机分为A组、B组。2组患者均接受布地奈德福莫特罗吸入粉雾剂（Ⅱ）联合孟鲁司特钠片治疗。A组给予布地奈德福莫特罗吸入粉雾剂，每日早晚各1次，每次2吸；B组给予布地奈德福莫特罗吸入粉雾剂（Ⅱ），每日早晚各1次，每次4吸。布地奈德福莫特罗吸入粉雾剂持续治疗6个月，孟鲁司特钠片1次10 mg，1日1次，持续治疗至少3个月。比较2组患者治疗前和治疗后的夜间咳嗽评分，比较2组患者1秒钟用力呼气量（FEV1）占预计值百分比、最大呼气中期流速（MMEF）、呼出气一氧化氮（FeNO）、白细胞介素-5（IL-5）、1年内的复发率，并进行安全性评价。

结果

A组入组45例，B组入组45例。治疗后9个月，A组和B组的夜间咳嗽评分分别为（0.93±0.42）和（0.65±0.29）分，FEV1占预计值百分比分别为（97.75±9.67）%和（100.93±11.06）%，MMEF分别为（2.81±1.04）和（3.08±1.09）L·s-1，FeNO分别为（18.94±9.75）和（15.94±7.96）ppb，IL-5分别为（10.88±7.06）和（8.11±5.56）pg·mL-1。B组的上述指标与A组比较，在统计学上差异均有统计学意义（均P<0.05）。A组与B组的药物不良反应总发生率分别为8.89%（5例/45例）和13.33%（6例/45例），复发率分别为15.56%（7例/45例）和13.33%（6例/45例）。B组的上述指标与A组比较，在统计学上差异均无统计学意义（均P>0.05）。

结论

对于老年CVA患者，用较高剂量的布地奈德福莫特罗吸入粉雾剂（Ⅱ）联合孟鲁司特钠片可以更好地改善咳嗽症状，降低气道高反应性和炎性因子水平，降低复发率，且患者耐受良好。

, authors=孙莹1a, 宋昕1a, 王佳1a, 侯艳芳1b, 付群1a, 张琦1a, 赖杰1a, 耿涛1a, 李长新1a, 霍佳慧1a, 张影2, 翁艳1c, authorsList=孙莹, 宋昕, 王佳, 侯艳芳, 付群, 张琦, 赖杰, 耿涛, 李长新, 霍佳慧, 张影, 翁艳, authorCompany=null, correspAuthors=翁艳, authorNote=

孙莹（1981-），女，硕士，副主任医师，主要从事呼吸与危重症方面的临床诊疗工作

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翁艳，副主任医师 MP: 13521732499 E-mail:
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布地奈德福莫特罗吸入粉雾剂治疗老年咳嗽变异性哮喘患者的临床研究
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孙莹 1a , 宋昕 1a , 王佳 1a , 侯艳芳 1b , 付群 1a , 张琦 1a , 赖杰 1a , 耿涛 1a , 李长新 1a , 霍佳慧 1a , 张影 2 , 翁艳 1c
中国临床药理学杂志 | 临床与基础桥接研究 2025,41(1): 1-5
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中国临床药理学杂志 |临床与基础桥接研究 2025 , 41 (1) : 1 -5
布地奈德福莫特罗吸入粉雾剂治疗老年咳嗽变异性哮喘患者的临床研究
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孙莹1a, 宋昕1a, 王佳1a, 侯艳芳1b, 付群1a, 张琦1a, 赖杰1a, 耿涛1a, 李长新1a, 霍佳慧1a, 张影2, 翁艳1c
作者信息
  • 1a.应急管理部应急总医院，综合医疗科，北京 100028
  • 1b.应急管理部应急总医院，呼吸与危重症医学科，北京 100028
  • 1c.应急管理部应急总医院，消化内科，北京 100028
  • 2.吉林省中西医结合医院 供应室，吉林 吉林 132012
通讯作者:
翁艳，副主任医师 MP: 13521732499 E-mail:
作者简介:

孙莹（1981-），女，硕士，副主任医师，主要从事呼吸与危重症方面的临床诊疗工作

Clinical trial of budesonide and formoterol fumarate powder for inhalation in the treatment of elderly patients with cough variant asthma
Ying SUN1a, Xin SONG1a, Jia WANG1a, Yan-fang HOU1b, Qun FU1a, Qi ZHANG1a, Jie LAI1a, Tao GENG1a, Chang-xin LI1a, Jia-hui HUO1a, Ying ZHANG2, Yan WENG1c
Affiliations
  • 1a.Comprehensive Medical Department, Emergency Management Department Emergency General Hospital, Beijing 100028, China
  • 1b.Respiratory and Critical Care Medicine Department, Emergency Management Department Emergency General Hospital, Beijing 100028, China
  • 1c.Gastroenterology Department, Emergency Management Department Emergency General Hospital, Beijing 100028, China
  • 2.Supply Department, Jilin Province Integrated Traditional Chinese and Western Medicine Hospital, Jilin 132012, Jilin Province, China
出版时间: 2025-01-17 doi: 10.13699/j.cnki.1001-6821.2025.01.001
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摘要
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目的

比较不同剂量的布地奈德福莫特罗吸入粉雾剂（Ⅱ）联合孟鲁司特钠片治疗咳嗽变异性哮喘（CVA）患者的效果及对气道功能、炎症因子的改善情况。

方法

将老年CVA患者随机分为A组、B组。2组患者均接受布地奈德福莫特罗吸入粉雾剂（Ⅱ）联合孟鲁司特钠片治疗。A组给予布地奈德福莫特罗吸入粉雾剂，每日早晚各1次，每次2吸；B组给予布地奈德福莫特罗吸入粉雾剂（Ⅱ），每日早晚各1次，每次4吸。布地奈德福莫特罗吸入粉雾剂持续治疗6个月，孟鲁司特钠片1次10 mg，1日1次，持续治疗至少3个月。比较2组患者治疗前和治疗后的夜间咳嗽评分，比较2组患者1秒钟用力呼气量（FEV1）占预计值百分比、最大呼气中期流速（MMEF）、呼出气一氧化氮（FeNO）、白细胞介素-5（IL-5）、1年内的复发率，并进行安全性评价。

结果

A组入组45例，B组入组45例。治疗后9个月，A组和B组的夜间咳嗽评分分别为（0.93±0.42）和（0.65±0.29）分，FEV1占预计值百分比分别为（97.75±9.67）%和（100.93±11.06）%，MMEF分别为（2.81±1.04）和（3.08±1.09）L·s-1，FeNO分别为（18.94±9.75）和（15.94±7.96）ppb，IL-5分别为（10.88±7.06）和（8.11±5.56）pg·mL-1。B组的上述指标与A组比较，在统计学上差异均有统计学意义（均P<0.05）。A组与B组的药物不良反应总发生率分别为8.89%（5例/45例）和13.33%（6例/45例），复发率分别为15.56%（7例/45例）和13.33%（6例/45例）。B组的上述指标与A组比较，在统计学上差异均无统计学意义（均P>0.05）。

结论

对于老年CVA患者，用较高剂量的布地奈德福莫特罗吸入粉雾剂（Ⅱ）联合孟鲁司特钠片可以更好地改善咳嗽症状，降低气道高反应性和炎性因子水平，降低复发率，且患者耐受良好。

布地奈德福莫特罗吸入粉雾剂（Ⅱ）  /  孟鲁司特钠片  /  咳嗽变异性哮喘  /  剂量  /  老年患者  /  小气道功能
Objective

To compare the effects of different doses of budesonide and formoterol fumarate powder for inhalation combined with montelukast sodium tablet in the treatment of cough variant asthma (CVA) and the improvement of airway function and inflammatory factors.

Methods

Elderly patients with cough variant asthma were randomly divided into group A and group B. Both groups of patients received budesonide and formoterol fumarate powder for inhalation combined with montelukast sodium tablet. Group A was given budesonide and formoterol fumarate powder for inhalation(Ⅱ), 2 inhalation per time, twice a day; Group B was given budesonide and formoterol fumarate powder for inhalation, 4 inhalation per time, twice a day; budesonide fumatrol inhalation powder mist for continuous treatment for 6 months, and montelukast sodium tablet 10 mg once a day for at least 3 months. The nighttime cough scores of the two groups were compared before treatment and after treatment. The percentage of forced expiratory volume in one second (FEV1) in the predicted value, the maximum mid expiratory flow (MMEF), the fractional exhaled nitric oxide (FeNO), interleukin-5 (IL-5) and eosinophils were compared between the two groups. The incidence of adverse drug reactions and the recurrence rate within 1 year were compared between the two groups.

Results

A total of 45 cases were enrolled in both the group A and the group B. At 9 months after treatment, the nocturnal cough scores of the group A and the group B were (0.93±0.42) and (0.65±0.29) points, respectively; the percentage of FEV1 in the predicted value were (97.75±9.67)% and (100.93±11.06)%, respectively; the MMEF values were (2.81±1.04) and (3.08±1.09) L·s-1, respectively; the FeNO values were (18.94±9.75) and (15.94±7.96) ppb, respectively; the IL-5 levels were (10.88±7.06) and (8.11±5.56) pg·mL-1, respectively. The above indicators in group B showed statistically significant differences compared to group A (all P<0.05). The total incidence of adverse drug reactions in group A and group B were 8.89% (5 cases/45 cases) and 13.33% (6 cases/45 cases), respectively. The recurrence rates was 15.56% (7 cases/45 cases) and 13.33% (6 cases/45 cases), respectively. There was no statistically significant difference in the above indicators between group B and group A (all P>0.05).

Conclusion

For elderly patients with CVA, higher dose of budesonide and formoterol fumarate powder for inhalation combined with montelukast sodium tablet can better improve cough symptoms, reduce the level of airway hyperresponsiveness and inflammatory factors, reduce the recurrence rate, and the patients are well tolerated.

budesonide and formoterol fumarate powder for inhalation(Ⅱ)  /  montelukast sodium tablet  /  cough variant asthma  /  dose  /  elderly patients  /  small airway function
孙莹, 宋昕, 王佳, 侯艳芳, 付群, 张琦, 赖杰, 耿涛, 李长新, 霍佳慧, 张影, 翁艳. 布地奈德福莫特罗吸入粉雾剂治疗老年咳嗽变异性哮喘患者的临床研究. 中国临床药理学杂志, 2025 , 41 (1) : 1 -5 . DOI: 10.13699/j.cnki.1001-6821.2025.01.001
Ying SUN, Xin SONG, Jia WANG, Yan-fang HOU, Qun FU, Qi ZHANG, Jie LAI, Tao GENG, Chang-xin LI, Jia-hui HUO, Ying ZHANG, Yan WENG. Clinical trial of budesonide and formoterol fumarate powder for inhalation in the treatment of elderly patients with cough variant asthma[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (1) : 1 -5 . DOI: 10.13699/j.cnki.1001-6821.2025.01.001

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doi: 10.13699/j.cnki.1001-6821.2025.01.001
  • 接收时间：2024-04-26
  • 首发时间：2026-08-04
  • 出版时间：2025-01-17
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  • 收稿日期：2024-04-26
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    1a.应急管理部应急总医院，综合医疗科，北京 100028
    1b.应急管理部应急总医院，呼吸与危重症医学科，北京 100028
    1c.应急管理部应急总医院，消化内科，北京 100028
    2.吉林省中西医结合医院 供应室，吉林 吉林 132012

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翁艳，副主任医师 MP: 13521732499 E-mail:
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
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