Article(id=1291338984165200050, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1722441600000, receivedDateStr=2024-08-01, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808805742, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808805742, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808805742, creator=13041195026, updateTime=1785808805742, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=60, endPage=64, ext={EN=ArticleExt(id=1291338985029226675, articleId=1291338984165200050, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Study of astaxanthin improves gouty chondrocyte injury induced by sodium urate crystals, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the protective effect of astaxanthin (ASTA) on gouty chondrocyte injury induced by monosodium urate crystal (MSU) and its mechanism.
Methods The gout cell model by sodium urate crystals was established. C-28I2 cells were randomly divided into blank group (conventional culture), model group (200 μg·mL-1 MSU), experimental-L group (200 μg·mL-1 MSU+20 μmol·mL-1 ASTA), experimental-H group (200 μg·mL-1 MSU+40 μmol·L-1 ASTA), experimental-H+Vector group (transfected with Vector +200 μg·mL-1 MSU+40 μmol·L-1 ASTA), experimental-H+NLRP3 group (transfected with NLRP3 plasmid +200 μg·mL-1 MSU+40 μmol·L-1 ASTA). Cell counting kit-8 (CCK-8) assay was used to detect the cell proliferation rate; Western blot assay was used to detect the expression of related proteins; the levels of Hyp and GAG were detected by enzyme-linked immunosorbent assay (ELISA).
Results The cell proliferation rate of blank group, model group, experimental-L group and experimental-H group were (100.00±5.40)%, (67.41±4.52)%, (72.69±5.05)% and (81.47±7.73)%, respectively. The above indicators showed statistically significant differences between the model group and the blank group, between the experimental-L, experimental-H groups and the model group (all P<0.05). Nucleotide binding oligomeric domain-like receptor protein 3 (NLRP3) protein expression levels in blank group, model group, experimental-L group, experimental-H group, experimental-H+Vector group and experimental-H+NLRP3 group were 0.44±0.04, 0.86±0.06, 0.72±0.10, 0.52±0.03, 0.51±0.03 and 1.13±0.10, respectively; the expression levels of cleaved Caspase-1 (Cl-caspase-1) protein were 0.33±0.05, 0.73±0.08, 0.61±0.07, 0.42±0.04, 0.39±0.04 and 0.70±0.06, respectively; the mature interleukin (m-IL)-1β protein expression levels were 0.26±0.03, 0.91±0.05, 0.70±0.11, 0.57±0.08, 0.58±0.06 and 0.79±0.08, respectively; the Hyp levels were (1.95±0.22), (3.33±0.25), (2.53±0.18), (2.22±0.21), (2.24±0.20) and (3.25±0.38) μg·mL-1, respectively; the GAG levels were (2.30±0.20), (3.71±0.26), (3.29±0.33), (2.90±0.16), (2.97±0.24) and (3.50±0.34) ng·mL-1, respectively. The above indicators showed statistically significant differences between the model group and the blank group, between the experimental-L, experimental-H groups and the model group, between the experimental-H+NLRP3 group and the experimental-H+Vector group (all P<0.05).
Conclusion Astaxanthin can regulate NLRP3 to play an anti-inflammatory role and has a protective effect on MSU-induced gouty cartilage injury.
, authors=Xiu-lin GAO
1, Li-qing ZHANG
2, Wei-feng LU
1, authorsList=Xiu-lin GAO, Li-qing ZHANG, Wei-feng LU, authorCompany=null, correspAuthors=Xiu-lin GAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291338986690171060, articleId=1291338984165200050, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=虾青素改善尿酸钠盐晶体诱导的痛风性软骨细胞损伤的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨虾青素（ASTA）对尿酸钠盐晶体（MSU）诱导的痛风性软骨细胞损伤的保护作用及其作用机制。
方法 用尿酸钠盐建立痛风性细胞模型。将C-28I2细胞随机分为空白组（常规培养）、模型组（200 μg·mL-1MSU）、低剂量实验组（200 μg·mL-1MSU+20 μmol·L-1 ASTA）、高剂量实验组（200 μg·mL-1 MSU+40 μmol·L-1 ASTA）、高剂量+Vector组（转染Vector载体+200 μg·mL-1MSU+40 μmol·L-1 ASTA）、高剂量+NLRP3组（转染过表达NLRP3质粒+200 μg·mL-1MSU+40 μmol·L-1 ASTA）。用细胞计数试剂盒-8（CCK-8）检测细胞的增殖情况，用蛋白质印迹法检测相关蛋白相对表达水平，用酶联免疫吸附试验（ELISA）法检测细胞羟脯氨酸（Hyp）、糖胺聚糖（GAG）水平。
结果 空白组、模型组、低剂量实验组、高剂量实验组的细胞增殖率分别为（100.00±5.40）%、（67.41±4.52）%、（72.69±5.05）%和（81.47±7.73）%，模型组的上述指标与空白组比较，低剂量实验组、高剂量实验组的上述指标与模型组分别比较，在统计学上差异均有统计学意义（均P<0.05）。空白组、模型组、低剂量实验组、高剂量实验组、高剂量+Vector组、高剂量+NLRP3组的核苷酸结合寡聚化结构域样受体蛋白3（NLRP3）蛋白相对表达水平分别为0.44±0.04、0.86±0.06、0.72±0.10、0.52±0.03、0.51±0.03和1.13±0.10，裂解的-胱天蛋白酶（Cl-caspase-1）蛋白相对表达水平分别为0.33±0.05、0.73±0.08、0.61±0.07、0.42±0.04、0.39±0.04和0.70±0.06，成熟-白细胞介素（m-IL）-1β蛋白相对表达水平分别为0.26±0.03、0.91±0.05、0.70±0.11、0.57±0.08、0.58±0.06和0.79±0.08，Hyp水平分别为（1.95±0.22）、（3.33±0.25）、（2.53±0.18）、（2.22±0.21）、（2.24±0.20）和（3.25±0.38）μg·mL-1，GAG水平分别为（2.30±0.20）、（3.71±0.26）、（3.29±0.33）、（2.90±0.16）、（2.97±0.24）和（3.50±0.34）ng·mL-1。模型组的上述指标与空白组比较，低剂量实验组、高剂量实验组的上述指标分别与模型组比较，高剂量+NLRP3组的上述指标与高剂量+Vector组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 虾青素可调控NLRP3发挥抗炎作用，在MSU诱导的痛风性软骨损伤中具有保护作用。
, authors=高秀林
1, 张丽卿
2, 陆伟锋
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高秀林（1987-），女，讲师，主要从事风湿性疾病临床诊治方面的工作
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