Article(id=1291338972387598394, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.027, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1717948800000, receivedDateStr=2024-06-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808802935, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808802935, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808802935, creator=13041195026, updateTime=1785808802935, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=132, endPage=136, ext={EN=ArticleExt(id=1291338973213876283, articleId=1291338972387598394, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status on the therapeutic potential of paeoniflorin in renal fibrosis based on the PI3K/Akt/mTOR signaling pathway, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway plays a crucial role in the regulation of renal fibrosis by participating in inflammatory response, oxidative stress and autophagy. Paeoniflorin exhibits remarkable efficacy in treating myocardial and liver fibrosis. This article provides a comprehensive review on the research progress of paeoniflora in preventing and treating renal fibrosis through modulation of the PI3K/Akt/mTOR signaling pathway, offering novel insights for traditional Chinese medicine-based approaches to prevent and treat renal fibrosis.

, authors=Lin-zhen JIA^1a, Tian-tian HAN^1a, Li-bo WEN^{1b, 2}, Kun ZHAO^{1b, 2}, Ren-jun GAO³, Ying LÜ^1b, Xue LI^{1b, 2}, authorsList=Lin-zhen JIA, Tian-tian HAN, Li-bo WEN, Kun ZHAO, Ren-jun GAO, Ying LÜ, Xue LI, authorCompany=null, correspAuthors=Xue LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291338975701098556, articleId=1291338972387598394, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于PI3K/Akt/mTOR信号通路探讨芍药苷治疗肾纤维化的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物西罗莫司靶蛋白（PI3K/Akt/mTOR）信号通路可以通过参与炎症反应、氧化应激和自噬来调控肾纤维化的发生发展。芍药苷对治疗心肌和肝纤维化效果显著。本文就芍药苷基于PI3K/Akt/mTOR信号通路防治肾纤维化的相关研究进行综述，为中医药防治肾纤维化提供了新的思路。

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贾淋珍（1998-），女，硕士研究生，主要从事肾药理学的相关研究

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贾淋珍（1998-），女，硕士研究生，主要从事肾药理学的相关研究

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