Article(id=1292135434704941779, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.11.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1766678400000, receivedDateStr=2025-12-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998694349, onlineDateStr=2026-08-06, pubDate=1781625600000, pubDateStr=2026-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998694349, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998694349, creator=13701087609, updateTime=1785998694349, updator=13701087609, issue=Issue{id=1292135402790482407, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1781625600000', pubDateStr='2026-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785998686739, creator='13701087609', updateTime=1786014315540, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292200954833686587, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292200954833686588, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1590, endPage=1594, ext={EN=ArticleExt(id=1292135435074040532, articleId=1292135434704941779, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=A hospital-wide intervention and evaluation of utilizing PDCA cycle and medication pathways to improve rational use of proton pump inhibitors, columnId=1291704944038536012, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Rational Use of Drugs, runingTitle=null, highlight=null, articleAbstract=
Objective To evaluate the effectiveness of the plan-do-check-act (PDCA) cycle combined with a drug use pathway in managing the rational use of proton pump inhibitors (PPIs) hospital-wide.
Methods Based on evidence-based medicine, PPI treatment and prophylactic medication pathways were established and implemented through the PDCA cycle. The changes in PPI usage rationality, quarterly average sales amount and its proportion of total drug consumption, medication frequency (DDDs), usage intensity (AUD), medication structure and intravenous usage rate in hospitalized patients were compared before implementation (fourth quarter of 2023) and after implementation (first to third quarters of 2024).
Results After the implementation of medication pathways, the rationality of PPI use across the hospital significantly improved. The prescription compliance rate increased from 95.17% (571 prescription/600 prescription) to 98.50% (589 prescription /600 prescription), and the order compliance rate rose from 93.33% (140 prescription /150 prescription) to 97.33% (149 prescription /150 prescription). Costs also decreased, with quarterly consumption dropping from 37.82 to 25.98 million yuan, with a reduction of 31.31%, and the cost proportion declining from 0.97% to 0.80%, with a decrease of 17.53%. The reduction in usage intensity was greater than the total volume, with AUD decreasing from 208.48 to 126.28 (with a 39.43% reduction) and DDDs dropping from 153 071.29 to 103 490.17 (with a 32.39% reduction). The medication structure continued to optimize, with the proportion of high-cost PPIs decreasing from 52.35% to 38.28% (with a 26.88% reduction), while the proportion of centralized procurement/essential drugs increased from 40.99% to 42.42% (with a 3.45% rise). The intravenous usage rate declined from 15.51% to 14.67% (with a 5.41% reduction). The intervention effectively achieved the goals of cost control, quality improvement, and compliance.
Conclusion The PDCA cycle can effectively promote the implementation of drug use pathways and enhance the level of rational drug use.
, authors=Ping JIANG
1a, Tian WANG
1b, Nan YU
1c, Bing-hua LI
1a, authorsList=Ping JIANG, Tian WANG, Nan YU, Bing-hua LI, authorCompany=null, correspAuthors=Bing-hua LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135435812238038, articleId=1292135434704941779, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于PDCA循环与药物使用路径的全院质子泵抑制剂合理用药管控模式构建及效果评价, columnId=1291704944210502478, journalTitle=中国临床药理学杂志, columnName=合理用药, runingTitle=null, highlight=null, articleAbstract=
目的 探讨计划-执行-检查-处理（PDCA）循环联合药物使用路径对全院质子泵抑制剂合理用药的管控效果。
方法 依据循证医学制定质子泵抑制剂（PPI）治疗与预防性用药路径，通过PDCA循环实施管理，比较实施前（2023年第四季度）与实施后（2024年第一至第三季度）的PPI使用合理率、季度平均销售金额及占总药品消耗金额、住院患者用药频度（DDDs）、使用强度（AUD）、用药结构、以及住院患者静脉使用率等指标变化。
结果 药物使用路径实施后，全院PPI使用合理性显著提升，处方合格率从95.17%（571张/600张）升至98.50%（589张/600张），医嘱合格率从93.33%（140张/150张）升至97.33%（149张/150张）。费用同步下降，季度消耗金额由37.82降至25.98万元，下降31.31%，费用占比由0.97%回落至0.80%，降低17.53%。用药强度降幅大于总量，AUD由208.48降至126.28，降低39.43%，DDDs由153 071.29降至103 490.17，降低32.39%。结构持续优化，高值PPI占比由52.35%降至38.28%，降低26.88%，集采/基药占比由40.99%升至42.42%，升高3.45%。静脉使用率由15.51%降至14.67%，降低5.41%。干预有效达成控费、提质、合规目标。
结论 PDCA循环能有效推动药物使用路径落地，提升合理用药水平。
, authors=姜萍
1a, 王恬
1b, 于囡
1c, 李丙华
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姜萍（1983-），女，主管药师，硕士研究生，主要从事临床药学相关的工作和研究
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