Article(id=1292135457865884604, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.11.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1768147200000, receivedDateStr=2026-01-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998699870, onlineDateStr=2026-08-06, pubDate=1781625600000, pubDateStr=2026-06-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998699870, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998699870, creator=13701087609, updateTime=1785998699870, updator=13701087609, issue=Issue{id=1292135402790482407, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='11', pageStart='1501', pageEnd='1650', issueExtLink='null', onlineDate='null', pubDate='1781625600000', pubDateStr='2026-06-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1785998686739, creator='13701087609', updateTime=1786014315540, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292200954833686587, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292200954833686588, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135402790482407, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1525, endPage=1530, ext={EN=ArticleExt(id=1292135458075599805, articleId=1292135457865884604, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of low-dose mifepristone combined with dienogest in the treatment of ovarian chocolate cyst patients, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of low-dose mifepristone tablets combined with dienogest tablets in the treatment of ovarian chocolate cyst patients.
Methods Patients with ovarian endometriomas were divided to control group, treated with dinoprost tablets at a dose of 2 mg once daily (qd), while the treatment group received additional low-dose mifepristone tablets at 5 mg qd in addition to the control regimen. Both groups were treated for 6 months. The clinical efficacy, dysmenorrhea symptom scores, hormone levels, carbohydrate antigen 125 (CA125) levels, endometrial thickness, uterine volume, inflammatory factor levels, and safety profiles before and after treatment were compared.
Results A total of 123 patients were enrolled, with 63 cases in the control group and 60 cases in the treatment group. The treatment group demonstrated a significantly higher overall response rate [91.67% (55 cases/60 cases) vs. 77.78% (49 cases/63 cases), P<0.05]. After treatment, the visual analog scale (VAS) scores of the control group and the treatment group were (2.13±0.67) and (1.78±0.55) points, respectively; the dysmenorrhea symptom scale (CMSS) scores were (21.78±4.19) and (19.86±4.54) points, respectively; the levels of FSH in the control group and the treatment group were (5.06±1.11) and (4.48±1.17) U·L-1, respectively; the levels of estradiol (E2) were (204.43±34.68) and (185.73±35.14) pmol·L-1, respectively; the levels of progesterone (P) were (12.14±2.43) and (10.81±2.29) ng·mL-1, respectively; the levels of CA125 were (37.31±4.34) and (33.12±4.49) U·mL-1, respectively; endometrial thickness was (5.88±1.46) and (5.15±1.32) mm, respectively; the uterine volume was (106.15±13.62) and (98.89±11.57) cm3, respectively; the levels of interleukin-6 (IL-6) in the control group and treatment group were (14.38±2.19) and (13.44±2.05) ng·L-1, respectively; the levels of IL-17 were (8.47±2.08) and (7.56±2.11) pg·mL-1, respectively; the levels of amyloid A (SAA) were (18.62±2.17) and (17.59±2.13) mg·L-1, respectively; the recurrence rate was 14.29% (9 cases/63 cases) and 5.00% (3 cases/60 cases), respectively; menstrual restoration time was (46.3±7.1) and (38.5±6.2) d, respectively; the differences of above indicators were all statistically significant compared betwwen two groups (P<0.05, P<0.01). The adverse drug reactions in the control group and the treatment group mainly included headache, breast discomfort, and mild irregular bleeding and the incidence was 9.52% (6 cases/63 cases) in the control group and 11.67% (7 cases/60 cases) in the treatment group (P>0.05).
Conclusion For patients with ovarian chocolate cysts, low-dose mifepristone tablets combined with dienogest tablets represents a valuable therapeutic strategy, offering enhanced pain relief, hormonal control, and overall efficacy compared to dienogest monotherapy, alongside a comparable safety profile.
, authors=Wen-qun CHEN, Qi HUANG, Yu-lian ZHUO, Qiong WU, Yu-ping MA, authorsList=Wen-qun CHEN, Qi HUANG, Yu-lian ZHUO, Qiong WU, Yu-ping MA, authorCompany=null, correspAuthors=Yu-ping MA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135458331452350, articleId=1292135457865884604, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=低剂量米非司酮联合地诺孕素治疗卵巢巧克力囊肿患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察低剂量米非司酮片联合地诺孕素片治疗卵巢巧克力囊肿患者的临床疗效和安全性。
方法 将卵巢巧克力囊肿患者依据治疗方法分为对照组和试验组。对照组给予地诺孕素片治疗，每次2 mg，qd，试验组组给在对照组的基础上联合低剂量米非司酮片治疗，每次5 mg，qd。2组均治疗6个月。比较2组患者治疗前后的临床疗效、痛经症状评分、激素水平、糖类抗原125（CA125）水平、子宫内膜厚度、子宫体积、炎症因子水平并进行安全性评价。
结果 本研究共入组123例，对照组63例，试验组60例。治疗后，对照组和试验组组的总有效率分别为77.78%（49例/63例）、91.67%（55例/60例）（P<0.05）。治疗后，对照组和试验组的视觉模拟评分（VAS）分别为（2.13±0.67）和（1.78±0.55）分，痛经症状评分量表（CMSS）分别为（21.78±4.19）和（19.86±4.54）分，卵泡刺激素（FSH）水平分别为（5.06±1.11）和（4.48±1.17）U·L-1，雌二醇（E2）水平分别为（204.43±34.68）和（185.73±35.14）pmol·L-1，孕酮（P）水平分别为（12.14±2.43）和（10.81±2.29）ng·mL-1，CA125水平分别为（37.31±4.34）和（33.12±4.49）U·mL-1，子宫内膜厚度分别为（5.88±1.46）和（5.15±1.32）mm，子宫体积分别为（106.15±13.62）和（98.89±11.57）cm3，白细胞介素-6（IL-6）水平分别为（14.38±2.19）和（13.44±2.05）ng·L-1，IL-17水平分别为（8.47±2.08）和（7.56±2.11）pg·mL-1，淀粉样蛋白A（SAA）水平分别为（18.62±2.17）和（17.59±2.13）mg·L-1，复发率分别为14.29%（9例/63例）和5.00%（3例/60例），月经恢复时间分别为（46.3±7.1）和（38.5±6.2）d，试验组的上述指标水平均显著低于对照组（P<0.05，P<0.01）。对照组和试验组药物不良反应主要包括头痛、乳房不适、轻微不规则出血等，2组药物不良反应发生率为分别为9.52%（6例/63例）和11.67%（7例/60例）（P>0.05）。
结论 低剂量米非司酮片联合地诺孕素片治疗卵巢巧克力囊肿患者效果优于单独使用地诺孕素片治疗，可提高疗效，显著缓解患者疼痛，调节生殖激素水平，且安全性较好。
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陈文群（1990-），女，主治医师，主要从事临床妇科疾病方面的工作和研究
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