中国临床药理学杂志

乌司他丁联合生长抑素对重症急性胰腺炎患者的临床研究

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曹丽丽 ^1a , 候亚林 ^1b , 于涛 ^1a , 李文嘉 ^1c , 朱子达 ^1d

中国临床药理学杂志 | 临床与基础桥接研究 2026,42(11): 1520-1524

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中国临床药理学杂志 |临床与基础桥接研究 2026 , 42 (11) : 1520 -1524

乌司他丁联合生长抑素对重症急性胰腺炎患者的临床研究

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曹丽丽^1a, 候亚林^1b, 于涛^1a, 李文嘉^1c, 朱子达^1d

作者信息

^1a.张家口市中医院重症医学科，河北张家口，075000

^1b.张家口市中医院皮肤科，河北张家口，075000

^1c.张家口市中医院心病科，河北张家口，075000

^1d.张家口市中医院急诊科，河北张家口，075000

通讯作者:

于涛，副主任医师 Tel: （0313）2566011 E-mail: YUtao382@163.com

作者简介:

曹丽丽（1988-），女，主治医师，主要从事重症急性胰腺炎方向的工作和研究

Clinical trial of somatostatin combined with ulinastatin in patients with severe acute pancreatitis

Li-li CAO^1a, Ya-lin HOU^1b, Tao YU^1a, Wen-jia LI^1c, Zi-da ZHU^1d

Affiliations

^1a.Department of Critical Care Medicine, Zhangjiakou Traditional Chinese Medicine Hospital, Zhangjiakou 075000, Hebei Province, China

^1b.Department of Dermatology, Zhangjiakou Traditional Chinese Medicine Hospital, Zhangjiakou 075000, Hebei Province, China

^1c.Department of Cardiology, Zhangjiakou Traditional Chinese Medicine Hospital, Zhangjiakou 075000, Hebei Province, China

^1d.Department of Emergency, Zhangjiakou Traditional Chinese Medicine Hospital, Zhangjiakou 075000, Hebei Province, China

出版时间: 2026-06-17 doi: 10.13699/j.cnki.1001-6821.2026.11.004

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摘要

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目的

探究乌司他丁注射液联合生长抑素对重症急性胰腺炎（SAP）患者的临床疗效和安全性。

方法

将SAP患者根据随机数表法分为对照组和试验组。2组患者均接受常规基础治疗，在此基础上，对照组加用生长抑素注射液（静脉滴注，每次6 mg，每日1次），试验组则在对照组的基础上，另外再给予乌司他丁注射液（静脉滴注，每次10万单位，每日3次），2组均持续治疗7天。比较2组的临床疗效、炎症因子水平、症状缓解时间、肠粘膜功能[D-乳酸、二胺氧化酶（DAO）和内毒素（Endotoxin）]，并进行安全性评价。

结果

本研究共纳入160例患者，试验组和对照组各80例。试验组和对照组的治疗总有效率分别为91.25%（73例/80例）和75.00%（60例/80例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的肿瘤坏死因子-α（TNF-α）水平分别为（22.46±5.90）和（28.85±6.37）pg·L^-1，白细胞介素-6（IL-6）水平分别为（92.03±20.22）和（122.78±27.59）pg·L^-1，Presepsin分水平别为（1.25±0.54）和（1.55±0.58）μg·L^-1，D-lactate水平分别为（5.31±0.75）和（8.19±0.93）mg·L^-1，DAO水平分别为（4.29±0.88）和（9.84±1.05）U·L^-1，Endotoxin水平分别为（0.63±0.18）和（1.21±0.25）EU·L^-1，腹痛缓解时间分别为（3.14±0.41）和（4.98±0.50）d，淀粉酶恢复正常时间分别为（4.33±0.46）和（5.36±0.56）d，2组上述指标比较，在统计学上差异均有统计学意义（均P<0.05）。对照组和试验组总药物不良反应发生率分别为6.25%（5例/80例）和6.25%（5例/80例），并发症发生率分别为3.75%（3例/80例）和2.50%（2例/80例），2组比较在统计学上差异均无统计学意义（均P>0.05）。

结论

在生长抑素的基础上应用乌司他丁治疗SAP患者可有效降低炎症因子水平，减轻炎症反应，促进肠粘膜功能恢复，联合方案在保证安全性的同时可显著提升疗效。

关键词

乌司他丁注射液 / 生长抑素注射液 / 重症急性胰腺炎 / 肠粘膜功能 / 可溶性白细胞分化抗原14亚型

Abstract

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Objective

To investigate the clinical efficacy and safety of somatostatin injection combined with ulinastatin injection in patients with severe acute pancreatitis (SAP).

Methods

Patients with SAP were divided into control group and experimental group by random number table method. Both groups received routine basic treatment. On this basis, the control group was additionally given somatostatin injection (6 mg once daily). The experimental group was treated with ulinastatin injection by intravenous infusion at a dose of 100 000 units three times a day on the basis of the control group. Both groups continued to receive treatment for 7 days. Compare the clinical efficacy, inflammatory factor levels, symptom relief time, intestinal mucosal function [D-lactate, diamine oxidase (DAO), and Endotoxin] of the two groups, and conduct a safety evaluation.

Results

A total of 160 patients were enrolled in this study, both the treatment group and the control group included 80 cases. The total effective rates in the treatment group and the control group were 91.25% (73 cases/80 cases) and 75.00% (60 cases/80 cases), respectively, with statistically significant difference (P<0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α) in the treatment group and the control group were (22.46±5.90) and (28.85±6.37) pg·L^-1, respectively; the levels of interleukin-6 (IL-6) were (92.03±20.22) and (122.78±27.59) pg·L^-1, respectively; the levels of Presepsin were (1.25±0.54) and (1.55±0.58) μg·L^-1, respectively; the levels of D-lactate were (5.31±0.75) and (8.19±0.93) mg·L^-1, respectively; the levels of DAO were (4.29±0.88) and (9.84±1.05) U·L^-1, respectively; the levels of endotoxin were (0.63±0.18) and (1.21±0.25) EU·L^-1, respectively; the duration of abdominal pain relief was (3.14±0.42) and (4.98±0.51) d, respectively; the time for amylase to return to normal was (4.32±0.46) and (5.37±0.56) d, respectively. All these differences of the aforementioned indicators were statistically significant in both groups (P<0.05). The incidence of adverse drug reactions during treatment in the control group and the treatment group was 6.25% (5 cases/80 cases) and 6.25% (5 cases/80 cases), respectively, and the incidence of complications was 3.75% (3 cases/80 cases) and 2.50% (2 cases/80 cases), respectively. There were no statistical differences between the two groups (P>0.05).

Conclusion

Ulinastatin combined with somatostatin in the treatment of SAP patients can effectively reduce the levels of inflammatory factors, alleviate inflammatory response, promote the recovery of intestinal mucosal function, and has better curative effect, without increasing the occurrence of adverse reactions, with certain safety and effectiveness.

Key words

ulinastatin injection / somatostatin injection / severe acute pancreatitis / intestinal mucosal function / soluble CD14 subtype

引用本文

曹丽丽, 候亚林, 于涛, 李文嘉, 朱子达. 乌司他丁联合生长抑素对重症急性胰腺炎患者的临床研究. 中国临床药理学杂志, 2026 , 42 (11) : 1520 -1524 . DOI: 10.13699/j.cnki.1001-6821.2026.11.004

Li-li CAO, Ya-lin HOU, Tao YU, Wen-jia LI, Zi-da ZHU. Clinical trial of somatostatin combined with ulinastatin in patients with severe acute pancreatitis[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (11) : 1520 -1524 . DOI: 10.13699/j.cnki.1001-6821.2026.11.004

基金

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河北省中医药科学研究课题基金资助项目(2023399)
张家口市2023年市级科技计划自筹经费基金资助项目(2322036D)

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2026年第42卷第11期

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文章信息

doi: 10.13699/j.cnki.1001-6821.2026.11.004

接收时间：2026-02-25
首发时间：2026-08-06
出版时间：2026-06-17

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收稿日期：2026-02-25

基金

河北省中医药科学研究课题基金资助项目(2023399)

张家口市2023年市级科技计划自筹经费基金资助项目(2322036D)

作者信息

^1a.张家口市中医院重症医学科，河北张家口，075000

^1b.张家口市中医院皮肤科，河北张家口，075000

^1c.张家口市中医院心病科，河北张家口，075000

^1d.张家口市中医院急诊科，河北张家口，075000

通讯作者:

于涛，副主任医师 Tel: （0313）2566011 E-mail: YUtao382@163.com

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https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.11.004

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2种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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