Article(id=1292135536370668065, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.10.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1770566400000, receivedDateStr=2026-02-09, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998718587, onlineDateStr=2026-08-06, pubDate=1779897600000, pubDateStr=2026-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998718587, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998718587, creator=13701087609, updateTime=1785998718587, updator=13701087609, issue=Issue{id=1292135425250976333, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='10', pageStart='1351', pageEnd='1500', issueExtLink='null', onlineDate='null', pubDate='1779897600000', pubDateStr='2026-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998692095, creator='13701087609', updateTime=1786014373634, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201198489202995, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201198489202996, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1462, endPage=1468, ext={EN=ArticleExt(id=1292135537968697890, articleId=1292135536370668065, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research advances in monitoring intracellular tacrolimus concentration for individualized treatment, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Tacrolimus (TAC) is a first-line immunosuppressive agent in clinical practice, with therapeutic decisions currently guided primarily by whole-blood concentration monitoring. However, with the deepening of research and clinical practice, it has been indicated that patients may experience suboptimal efficacy or toxic reactions even when whole-blood concentrations remain within the therapeutic window, rendering current monitoring strategies inadequate for clinical needs. TAC primarily acts within lymphocytes, making intracellular TAC concentration a more accurate indicator of its pharmacodynamic activity and a key driver for individualized treatment. Research on intracellular TAC levels remains in its early stages. Clarifying the relationship between intracellular TAC concentrations and clinical efficacy, identifying relevant influencing factors, and understanding the limitations of current detection technologies are crucial for promoting its standardized clinical application. Based on the pharmacokinetics and pharmacodynamics of TAC, this review summarizes the research progress on intracellular TAC concentrations domestically and internationally, aiming to provide insights for optimizing therapeutic drug monitoring of TAC.

, authors=Cheng-bin WANG, Wen-jie ZHU, authorsList=Cheng-bin WANG, Wen-jie ZHU, authorCompany=null, correspAuthors=Wen-jie ZHU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135538337796643, articleId=1292135536370668065, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=细胞内他克莫司浓度监测在个体化治疗中的研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

他克莫司（TAC）是临床一线免疫抑制剂，目前主要通过全血浓度监测指导临床给药。然而随着研究的深入及临床实践显示，即使全血浓度处于治疗窗内，患者仍可能出现疗效不佳或者毒性反应，现有监测策略不能满足临床需求。TAC主要作用于淋巴细胞内，因此检测细胞内TAC浓度能更准确地反映其药效学活性，进而促进个体化治疗。目前关于细胞内TAC浓度的研究尚处于早期阶段，明确细胞内TAC浓度与临床疗效的关系、相关影响因素以及当前检测技术的局限性对推动其临床规范化应用具有重要意义。本文从TAC药动学和药效学出发，综述国内外细胞内TAC浓度的研究进展，以期为优化TAC治疗药物监测提供参考。

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王成彬（1998-），男，药师，主要从事临床药学及临床药理学相关研究

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王成彬（1998-），男，药师，主要从事临床药学及临床药理学相关研究

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