Article(id=1292135530825798117, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.10.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1776096000000, receivedDateStr=2026-04-14, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998717265, onlineDateStr=2026-08-06, pubDate=1779897600000, pubDateStr=2026-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998717265, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998717265, creator=13701087609, updateTime=1785998717265, updator=13701087609, issue=Issue{id=1292135425250976333, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='10', pageStart='1351', pageEnd='1500', issueExtLink='null', onlineDate='null', pubDate='1779897600000', pubDateStr='2026-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998692095, creator='13701087609', updateTime=1786014373634, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201198489202995, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201198489202996, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1424, endPage=1432, ext={EN=ArticleExt(id=1292135531027124710, articleId=1292135530825798117, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Mechanisms of the lipid droplet-lysosome axis in Alzheimer’s disease and advances in regulation by traditional Chinese medicine, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder whose pathological process involves interactions among lipid metabolism disorders, abnormal protein aggregation, and organelle dysfunction. Recent studies have revealed that lipid droplets and lysosomes do not function independently; instead, they form a functional coupling via the lipophagy pathway, which is defined in this paper as the "lipid droplet lysosome axis". This axis centers on lipid droplet surface proteins (PLIN2, DGAT2, Rab7) and lysosomal functional molecules (v-ATPase, LAMP2A, cathepsins), achieving bidirectional regulation through membrane contact sites, material exchange, and the mTORC1-TFEB signaling feedback loop. Under AD pathology, dysregulation of this axis manifests as a vicious cycle in which abnormal lipid droplet accumulation and lysosomal dysfunction mutually exacerbate each other, thereby promoting Aβ deposition and tau phosphorylation. This review systematically elaborates the biological basis and dysregulation mechanisms of this axis, and based on this framework, constructs an "axis node-TCM component" mechanistic mapping. It summarizes evidence that active ingredients from traditional Chinese medicine, such as ginsenosides, restore axis function via nodes including TFEB, AMPK, and PPARα, and proposes research strategies and validation pathways for targeting this axis as a novel multi-target therapeutic approach for AD.

, authors=Jia-xuan HUANG^1a, Zi-he GUAN^1b, Min SUN^1b, Yu-xin JIANG^1a, Jia-qi FU^1a, Ying-ting FU^1a, Ming-xia ZHANG^1a, Wei-zhi CHANG^1b, authorsList=Jia-xuan HUANG, Zi-he GUAN, Min SUN, Yu-xin JIANG, Jia-qi FU, Ying-ting FU, Ming-xia ZHANG, Wei-zhi CHANG, authorCompany=null, correspAuthors=Wei-zhi CHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135531262005735, articleId=1292135530825798117, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=脂滴-溶酶体轴在阿尔茨海默病中的作用机制及中药调控进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

阿尔茨海默病（Alzheimer’s disease，AD）是一种多因素驱动的神经退行性疾病，其病理进程涉及脂质代谢紊乱、蛋白异常聚集及细胞器功能障碍的交互作用。近年研究揭示，脂滴与溶酶体并非孤立运作，而是通过脂噬途径形成功能耦联，本文将其界定为“脂滴-溶酶体轴”。该轴以脂滴表面蛋白（PLIN2、DGAT2、Rab7）与溶酶体功能分子（v-ATP酶、LAMP2A、组织蛋白酶）为核心节点，通过膜接触位点、物质交换及mTORC1-TFEB信号反馈实现双向调控。AD病理状态下，该轴失衡表现为脂滴异常积累与溶酶体功能障碍相互加剧的恶性循环，进而促进Aβ沉积及tau磷酸化。本文系统阐述该轴的生物学基础与失衡机制，并在此基础上构建“轴节点-中药成分”机制映射框架，归纳人参皂苷等中药活性成分通过TFEB、AMPK、PPARα等节点恢复轴功能的研究证据，提出该轴作为AD多靶点治疗新靶点的研究策略与验证路径。

, authors=黄嘉璇^1a, 关子赫^1b, 孙敏^1b, 江雨欣^1a, 付佳琪^1a, 付英婷^1a, 张明霞^1a, 常惟智^1b, authorsList=黄嘉璇, 关子赫, 孙敏, 江雨欣, 付佳琪, 付英婷, 张明霞, 常惟智, authorCompany=null, correspAuthors=常惟智, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=U6lQKVQlbffCFVeOL6YFZg==, magXml=1Di8D4zhCyAvuQzyjb9IKQ==, pdfUrl=null, pdf=Qr8JM4HhJogFSCmQ3W7JNQ==, pdfFileSize=1945016, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=laHXFtuL9p2GGU4lHY6IPg==, mapNumber=null, fund=null)}, authors=[Author(id=1292135531626910191, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292135531702407665, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135531626910191, language=EN, stringName=Jia-xuan HUANG, firstName=Jia-xuan, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292135533388517874, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135531626910191, language=CN, stringName=黄嘉璇, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000, bio={"content":"

黄嘉璇（2001-），女，硕士研究生，主要从阿尔兹海默症与临床中药学方面研究

"}, bioImg=null, bioContent=

黄嘉璇（2001-），女，硕士研究生，主要从阿尔兹海默症与临床中药学方面研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292135531450749416, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1a., ext=[AuthorCompanyExt(id=1292135531459138025, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531467526634, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000)])]), Author(id=1292135533455626740, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292135533560484342, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135533455626740, language=EN, stringName=Zi-he GUAN, firstName=Zi-he, middleName=null, lastName=GUAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292135533635981815, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135533455626740, language=CN, stringName=关子赫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.黑龙江中医药大学，基础医学院，黑龙江 哈尔滨 150000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292135531526246891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1b., ext=[AuthorCompanyExt(id=1292135531534635500, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531526246891, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531547218413, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531526246891, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.黑龙江中医药大学，基础医学院，黑龙江 哈尔滨 150000)])]), Author(id=1292135533711479289, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292135533778588155, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135533711479289, language=EN, stringName=Min SUN, firstName=Min, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292135533858279932, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135533711479289, language=CN, stringName=孙敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.黑龙江中医药大学，基础医学院，黑龙江 哈尔滨 150000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292135531526246891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1b., ext=[AuthorCompanyExt(id=1292135531534635500, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531526246891, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531547218413, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531526246891, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.黑龙江中医药大学，基础医学院，黑龙江 哈尔滨 150000)])]), Author(id=1292135533929583102, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292135534038635008, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135533929583102, language=EN, stringName=Yu-xin JIANG, firstName=Yu-xin, middleName=null, lastName=JIANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292135534109938177, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135533929583102, language=CN, stringName=江雨欣, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292135531450749416, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1a., ext=[AuthorCompanyExt(id=1292135531459138025, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531467526634, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000)])]), Author(id=1292135534298681859, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292135534365790725, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135534298681859, language=EN, stringName=Jia-qi FU, firstName=Jia-qi, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292135534445482502, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135534298681859, language=CN, stringName=付佳琪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292135531450749416, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1a., ext=[AuthorCompanyExt(id=1292135531459138025, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531467526634, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000)])]), Author(id=1292135534516785672, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292135534592283146, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135534516785672, language=EN, stringName=Ying-ting FU, firstName=Ying-ting, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292135534655197707, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135534516785672, language=CN, stringName=付英婷, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292135531450749416, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1a., ext=[AuthorCompanyExt(id=1292135531459138025, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531467526634, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000)])]), Author(id=1292135534734889485, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292135534818775567, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135534734889485, language=EN, stringName=Ming-xia ZHANG, firstName=Ming-xia, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292135534902661648, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135534734889485, language=CN, stringName=张明霞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1a, address=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292135531450749416, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1a., ext=[AuthorCompanyExt(id=1292135531459138025, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531467526634, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000)])]), Author(id=1292135534990742034, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=changweizhi@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1292135535078822420, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135534990742034, language=EN, stringName=Wei-zhi CHANG, firstName=Wei-zhi, middleName=null, lastName=CHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292135535137542677, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, authorId=1292135534990742034, language=CN, stringName=常惟智, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^1b, address=^1b.黑龙江中医药大学，基础医学院，黑龙江 哈尔滨 150000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292135531526246891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1b., ext=[AuthorCompanyExt(id=1292135531534635500, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531526246891, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531547218413, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531526246891, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.黑龙江中医药大学，基础医学院，黑龙江 哈尔滨 150000)])])], keywords=[Keyword(id=1292135535225623062, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=EN, orderNo=1, keyword=Alzheimer’s disease), Keyword(id=1292135535288537623, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=EN, orderNo=2, keyword=lipid droplets), Keyword(id=1292135535351452184, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=EN, orderNo=3, keyword=lysosomes), Keyword(id=1292135535414366745, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=EN, orderNo=4, keyword=research progress), Keyword(id=1292135535494058522, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=EN, orderNo=5, keyword=traditional Chinese medicine), Keyword(id=1292135535561167387, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=CN, orderNo=1, keyword=阿尔茨海默病), Keyword(id=1292135535628276252, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=CN, orderNo=2, keyword=脂滴), Keyword(id=1292135535712162333, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=CN, orderNo=3, keyword=溶酶体), Keyword(id=1292135535791854110, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=CN, orderNo=4, keyword=研究进展), Keyword(id=1292135535858962975, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, language=CN, orderNo=5, keyword=中医药)], refs=null, funds=[Fund(id=1292135535951237664, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, awardId=ZYW2024-019, language=CN, fundingSource=黑龙江省中医药科研项目(ZYW2024-019), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1292135531450749416, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1a., ext=[AuthorCompanyExt(id=1292135531459138025, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531467526634, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531450749416, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1a.黑龙江中医药大学，药学院，黑龙江 哈尔滨 150000)]), AuthorCompany(id=1292135531526246891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, xref=1b., ext=[AuthorCompanyExt(id=1292135531534635500, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531526246891, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.College of Basic Medicine, Heilongjiang University of Chinese Medicine, Harbin 150000, Heilongjiang Province, China), AuthorCompanyExt(id=1292135531547218413, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292135530825798117, companyId=1292135531526246891, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1b.黑龙江中医药大学，基础医学院，黑龙江 哈尔滨 150000)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.10.012, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2026.10.012, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2026.10.012, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2026.10.012, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1779897600000, fullTextJson=null, articleText=null, reference=null)