Article(id=1292135556012601959, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.10.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769616000000, receivedDateStr=2026-01-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998723270, onlineDateStr=2026-08-06, pubDate=1779897600000, pubDateStr=2026-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998723270, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998723270, creator=13701087609, updateTime=1785998723270, updator=13701087609, issue=Issue{id=1292135425250976333, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='10', pageStart='1351', pageEnd='1500', issueExtLink='null', onlineDate='null', pubDate='1779897600000', pubDateStr='2026-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998692095, creator='13701087609', updateTime=1786014373634, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201198489202995, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201198489202996, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1397, endPage=1402, ext={EN=ArticleExt(id=1292135556314591848, articleId=1292135556012601959, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Study on the correlation between tacrolimus trough concentration and clinical efficacy, and analysis of factors affecting the efficacy of lupus nephritis in children, columnId=1246531407389020354, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Pharmacokinetics and Bioequivalence Study, runingTitle=null, highlight=null, articleAbstract=
Objective Explore the correlation between tacrolimus trough concentration (C0) and clinical efficacy in children with lupus nephritis (LN), and identify key factors affecting the efficacy of tacrolimus treatment in LN patients..
Methods A total of 120 children with LN who took tacrolimus in our hospital from March 2021 to December 2024 and were monitored for blood drug concentration were retrospectively selected. According to the treatment effect, they were divided into effective group (n=78) and ineffective group (n=42). The basic information, laboratory indicators and other data of the children were collected to explore the influencing factors of the efficacy of the children.
Results The daily dose of tacrolimus, trough concentration C0, 24 h urinary protein and albumin in the effective group were higher than those in the ineffective group (all P<0.001), while the glomerular filtration rate was significantly lower than that in the ineffective group (P<0.001). After collinearity diagnosis, the indexes were included in Logistic regression analysis. The daily dose of tacrolimus, trough concentration C0, glomerular filtration rate and albumin were all protective factors affecting the efficacy of children with LN (P<0.05), while 24 h urine protein quantification was a risk factor (P<0.05). The receiver operating characteristic curve was drawn. The AUC of glomerular filtration rate, 24-hour urinary protein quantification, and albumin in predicting the efficacy of children with LN was 0.882 [95% CI: 0.809-0.956], 0.861 [ 95 % CI: 0.790-0.932], 0.897 [95% CI: 0.837-0.956]. The AUC and optimal cut-off value of tacrolimus daily dose and trough concentration C0 in predicting the efficacy of children with LN were 0.750 [95% CI : 0.649-0.851 ], 1.45 mg and 0.772 [ 95 % CI: 0.691-0.853 ], 4.05 ng·mL-1.
Conclusion The trough concentration of tacrolimus (C0) is significantly correlated with the clinical efficacy of LN in children, and the daily dose and trough concentration C0 are key factors affecting the efficacy.
, authors=Meng JIN, authorsList=Meng JIN, authorCompany=null, correspAuthors=Meng JIN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135556637553257, articleId=1292135556012601959, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=他克莫司谷浓度与临床疗效相关性研究及狼疮性肾炎患儿疗效影响因素分析, columnId=1246531407988805834, journalTitle=中国临床药理学杂志, columnName=药代动力学与生物等效性研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨他克莫司谷浓度（C0）与狼疮性肾炎（LN）患儿临床疗效的相关性，并识别他克莫司治疗LN患儿疗效的关键因素。
方法 回顾性选取2021年3月至2024年12月在我院服用他克莫司的120例儿童并进行血药浓度监测的LN患儿。根据治疗效果分组，分为有效组（n=78）、无效组（n=42）。收集患儿的基本信息、实验室指标等数据，探寻对患儿疗效的影响因素。
结果 有效组患儿的他克莫司日剂量、谷浓度C0、24 h尿蛋白定量、白蛋白均高于无效组（均P<0.001），而肾小球滤过率显著低于无效组（P<0.001）。经共线性诊断后，将指标纳入Logistic回归分析，他克莫司日剂量、谷浓度C0、肾小球滤过率、白蛋白均是影响LN患儿疗效的保护因素（P<0.05），而24 h尿蛋白定量是危险因素（P<0.05）。绘制受试者特征曲线，肾小球滤过率、24h尿蛋白定量、白蛋白预测LN患儿疗效的AUC分别为0.882[95%CI：0.809~0.956]、0.861[95%CI：0.790~0.932]、0.897[95%CI：0.837~0.956]。他克莫司日剂量、谷浓度C0预测LN患儿疗效的AUC和最佳临界值分别为0.750[95%CI：0.649~0.851]，1.45 mg和0.772[95%CI：0.691~0.853]，4.05 ng·mL-1。
结论 他克莫司谷浓度（C0）与LN患儿临床疗效显著相关，日剂量和谷浓度C0是影响疗效的关键因素。
, authors=金梦, authorsList=金梦, authorCompany=null, correspAuthors=金梦, authorNote=
金梦（1992-），女，主管药师，主要从事药物分析工作
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金梦（1992-），女，主管药师，主要从事药物分析工作
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