Article(id=1292135544142721551, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.10.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1774800000000, receivedDateStr=2026-03-30, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998720440, onlineDateStr=2026-08-06, pubDate=1779897600000, pubDateStr=2026-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998720440, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998720440, creator=13701087609, updateTime=1785998720440, updator=13701087609, issue=Issue{id=1292135425250976333, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='10', pageStart='1351', pageEnd='1500', issueExtLink='null', onlineDate='null', pubDate='1779897600000', pubDateStr='2026-05-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998692095, creator='13701087609', updateTime=1786014373634, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201198489202995, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201198489202996, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135425250976333, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1365, endPage=1370, ext={EN=ArticleExt(id=1292135544331465232, articleId=1292135544142721551, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=The efficacy of recombinant human brain natriuretic peptide combined with amiodarone in the treatment of elderly patients with HF and VA, and its impact on heart rate variability, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the clinical efficacy of recombinant human brain natriuretic peptide (rhBNP) combined with amiodarone on patients with elderly heart failure (HF) complicated with ventricular arrhythmia (VA) and its impact on heart rate variability (HRV).
Methods From January 2023 to January 2025, 220 patients with patients with elderly HF complicated with VA admitted to our hospital were prospectively selected and randomly separated into a control group (amiodarone) and an experimental group (rhBNP+amiodarone), with 110 patients in each group. The clinical outcomes, cardiac function, HRV indicators, serum N-terminal pro brain natriuretic peptide (NT-proBNP), QT interval dispersion (QTd), and adverse events were compared.
Results After treatment, the total effective rate in the experimental group was significantly higher than that in the control group (P<0.05). The experimental group had lower left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD), NT-proBNP, and QTd than the control group (P<0.05), and higher left ventricular ejection fraction (LVEF), cardiac output (CO), RMSSD, SDNN, and PNN50 than the control group (P<0.05).
Conclusion The combination of rhBNP and amiodarone has a conspicuous effect on patients with elderly HF complicated with VA. It can optimize cardiac function and HRV, improve electrophysiological stability, and has good safety.
, authors=Hua QIAN, Rui TONG, Shu-fan REN, Li-jun WANG, Yan LIU, authorsList=Hua QIAN, Rui TONG, Shu-fan REN, Li-jun WANG, Yan LIU, authorCompany=null, correspAuthors=Yan LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135544746701329, articleId=1292135544142721551, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=重组人脑利钠肽联合胺碘酮治疗老年HF合并VA的疗效及对心率变异性的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨重组人脑利钠肽（rhBNP）联合胺碘酮治疗老年心力衰竭（HF）合并室性心律失常（VA）的临床效果及对心率变异性（HRV）的影响。
方法 前瞻性选取2023年1月~2025年1月本院收治的老年HF合并VA患者220例，随机分为对照组（胺碘酮）、试验组（rhBNP+胺碘酮），各110例，比较2组的临床效果、心功能、HRV指标、血清N末端脑钠肽前体（NT-proBNP）水平、QT间期离散度（QTd）及药物不良反应。
结果 治疗后，试验组的总有效率大于对照组（P<0.05）；试验组的左心室收缩末期内径（LVESD）、左心室舒张末期内径（LVEDD）、NT-proBNP、QTd均低于对照组（P<0.05），左心室射血分数（LVEF）、心排量（CO）、RMSSD、SDNN、PNN50均高于对照组（P<0.05）。
结论 rhBNP联合胺碘酮治疗老年HF合并VA的效果显著，能够优化心功能及HRV，改善电生理稳定性，且安全性良好。
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钱华（1990-），女，主管技师，主要从事心脏电生理研究
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