Article(id=1292135503663485192, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.09.020, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1768924800000, receivedDateStr=2026-01-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785998710789, onlineDateStr=2026-08-06, pubDate=1778947200000, pubDateStr=2026-05-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785998710789, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785998710789, creator=13701087609, updateTime=1785998710789, updator=13701087609, issue=Issue{id=1292135444850955150, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='9', pageStart='1201', pageEnd='1350', issueExtLink='null', onlineDate='null', pubDate='1778947200000', pubDateStr='2026-05-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785998696767, creator='13701087609', updateTime=1786014392260, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201276780081469, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201276784275774, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292135444850955150, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1330, endPage=1337, ext={EN=ArticleExt(id=1292135504347156745, articleId=1292135503663485192, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on regulation of Nrf2/HO-1 signaling pathway by traditional Chinese medicine for prevention and treatment of diabetic kidney disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Diabetic kidney disease (DKD) is the most common and severe microvascular complication in clinical practice and one of the main causes for diabetic patients to develop chronic kidney disease and end-stage renal disease. The pathogenesis of this disease involves the combined effects of multiple factors, such as genetic factors, dysregulation of glucose and lipid metabolism, changes in renal hemodynamics, inflammatory responses and oxidative stress, among others. Among these, oxidative stress is the core process in the occurrence and development of DKD. The nuclear transcription factor E2-related factor (Nrf2) is an important regulatory factor for antioxidant stress transcription. Activating Nrf2 can stimulate the expression of downstream heme oxygenase-1 (HO-1), thereby widely participating in various biological processes such as regulating oxidative stress, reducing inflammatory responses and inhibiting cell apoptosis in the body. Recent studies have shown that the Nrf2/HO-1 signaling pathway is involved in the occurrence, development and drug intervention process of DKD. Traditional Chinese medicine (TCM) has the characteristics of multi-target, multi-pathway and multi-level, and the advantages of synergism and attenuation, showing unique advantages in making up for the shortcomings of modern medicine. However, there is still a lack of systematic summary of the mechanism of this pathway in the prevention and treatment of DKD and the research progress of traditional Chinese medicine. In this paper, the biological function and activation process of Nrf2/HO-1 pathway, the relationship between Nrf2/HO-1 pathway and DKD, the related research of traditional Chinese medicine to improve DKD by targeting the pathway in recent years, the treatment strategy of integrated traditional Chinese and western medicine, and the future research direction were systematically reviewed, in order to provide theoretical reference for the clinical treatment and drug development of DKD.

, authors=Ya-lan ZOU¹, Deng-juan MA¹, Ting-ting WU¹, Dong-kai YANG¹, Wei-jie YANG², authorsList=Ya-lan ZOU, Deng-juan MA, Ting-ting WU, Dong-kai YANG, Wei-jie YANG, authorCompany=null, correspAuthors=Wei-jie YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292135504586232074, articleId=1292135503663485192, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于Nrf2/HO-1信号通路探讨中医药干预糖尿病肾病的研究进展, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

糖尿病肾病（DKD）是临床最常见和最严重的一种糖尿病微血管并发症，是导致糖尿病患者发展至慢性肾病和终末期肾病的主要原因之一。其发病机制涉及多因素共同作用，如遗传因素、糖脂代谢紊乱、肾血流动力学改变、炎症反应与氧化应激等，而氧化应激是DKD发生发展的核心环节。核转录因子E2相关因子（Nrf2）是一种重要的调控抗氧化应激转录因子，激活Nrf2可以刺激下游血红素加氧-1（HO-1）的表达，从而在机体中广泛参与调节氧化应激、减轻炎症反应、抑制细胞凋亡等多种生物学过程。近年来，研究表明，Nrf2/HO-1信号通路参与DKD的发生发展及药物干预过程。中药具有多靶点、多途径、多层次的特点及增效减毒的优势，在弥补现代医学不足方面展现出独特优势。然而，目前有关该通路在DKD防治中的作用机制及中药研究进展尚缺乏系统性总结。本文就Nrf2/HO-1通路生物学功能，激活过程，与DKD的关系，近年来中药通过靶向调控该通路改善DKD的相关研究及中西医结合治疗策略、未来研究方向作一系统综述，以期为DKD的临床治疗和药物研发提供理论参考。

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邹亚兰（1984-），女，副主任医师，主要从事中西医结合防治糖尿病及其并发症方面的工作和研究

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邹亚兰（1984-），女，副主任医师，主要从事中西医结合防治糖尿病及其并发症方面的工作和研究

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