Article(id=1292130264776471390, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.08.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1772208000000, receivedDateStr=2026-02-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997461742, onlineDateStr=2026-08-06, pubDate=1777305600000, pubDateStr=2026-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997461742, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997461742, creator=13701087609, updateTime=1785997461742, updator=13701087609, issue=Issue{id=1292130221843571059, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1777305600000', pubDateStr='2026-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997451505, creator='13701087609', updateTime=1786014411018, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201355276480844, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201355276480845, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1151, endPage=1156, ext={EN=ArticleExt(id=1292130266479358817, articleId=1292130264776471390, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research on the effects and mechanism of ginsenoside Rb1 against hypoxia/reoxygenation-induced human pulmonary endothelial cell injury, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of ginsenoside Rb1 on hypoxia/reoxygenation (H/R)-induced injury in human pulmonary endothelial cells (HPECs) and its underlying mechanism.
Methods HPECs were randomly divided into control group(normal culture), model group(subjected to 3 h of hypoxia followed by 7 h of reoxygenation), and experimental group(pretreated with 0.1 μmol·L-1, 1.0 μmol·L-1, 10.0 μmol·L-1 and 100.0 μmol·L-1 ginsenoside Rb1 for 1 h prior to H/R). Cell viability was assessed using the CCK-8 assay. The levels of inflammatory factors including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were detected by enzyme-linked immunosorbent assay (ELISA). The intracellular adenosine triphosphate(ATP) content and the activities of mitochondrial respiratory chain complex Ⅰ (complex Ⅰ) and ATP synthase were detected by ELISA . The protein relative expression levels of glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), zonula occludens-1 (ZO-1), vascular endothelial cadherin (VE-cadherin) and ATP synthase F1 subunit delta (ATP5D) were measured by Western blot.
Results The cell viability of the control group, model group and experimental group(0.1, 1.0, 10.0 and 100.0 μmol·L-1)were 1.07±0.04, 0.61±0.06, 0.68±0.07, 0.80±0.06, 0.96±0.08 and 0.95±0.09, respectively, among which 10.0 μmol·L-1 showed the optimal protective effect and this concentration was therefore used for subsequent experimental group. The levels of IL-1β in the control group, model group and experimental group were (136.25±3.61), (200.12±8.56) and (149.50±9.20) ng·L-1, respectively; the levels of IL-6 were (4.95±0.26), (8.96±0.60) and (6.23±0.34)ng·L-1, respectively; the levels of TNF-α were (328.66±19.14), (461.54±26.39) and (391.77±17.22) ng·L-1, respectively; the relative expression levels of GRP78 were 0.84±0.15, 1.45±0.13 and 0.82±0.15, respectively; the relative expression levels of CHOP were 0.66±0.11, 1.20±0.41 and 0.76±0.14, respectively; the relative expression levels of ZO-1 were 0.81±0.11, 0.25±0.07 and 0.84±0.13, respectively; the relative expression levels of VE-cadherin were 0.75±0.12, 0.32±0.09 and 0.73±0.14, respectively; the relative expression levels of ATP5D were 0.88±0.16, 0.26±0.08 and 0.83±0.17, respectively; the activities of mitochondrial respiratory chain complex Ⅰ were 2.12±0.26, 1.40±0.17 and 1.82±0.15, respectively; the activities of ATP synthase were 2.14±0.25, 1.32±0.17 and 1.81±0.18, respectively; the contents of ATP were (86.32±8.50), (52.21±5.62) and (91.12±6.10) μmol·ug-1 protein, respectively; there were statistically significant differences in the above indicators between the model group and the control group, between the experimental group and the model group (all P<0.05).
Conclusion Ginsenoside Rb1 may alleviate H/R-induced HPECs injury, inflammatory response, and endoplasmic reticulum stress by improving mitochondrial function and increasing intracellular ATP content, thereby restoring normal cellular function.
, authors=Hong LI, Xin-yi LI, Zhong-hui LIU, Yu-qing OUYANG, Zhi-fang FU, Hong-mei JIAO, authorsList=Hong LI, Xin-yi LI, Zhong-hui LIU, Yu-qing OUYANG, Zhi-fang FU, Hong-mei JIAO, authorCompany=null, correspAuthors=Zhi-fang FU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130266911372130, articleId=1292130264776471390, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=人参皂苷Rb1对缺氧/复氧诱导的人肺血管内皮细胞损伤的作用及机制研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察人参皂苷Rb1对缺氧/复氧（H/R）诱导的人肺血管内皮细胞（HPECs）损伤的作用及其潜在机制。
方法 将HPECs随机分为对照组（正常培养）、模型组（予3 h缺氧处理后再进行7 h复氧）和实验组（H/R处理前1 h分别加入0.1、1.0、10.0和100.0 μmol·L-1的人参皂苷Rb1），用细胞计数试剂盒-8（CCK-8）检测法评估各组的细胞活力，用酶联免疫吸附实验法（ELISA）检测白细胞介素-1β（IL-1β）、IL-6、肿瘤坏死因子-α（TNF-α）等炎症因子含量，及线粒体呼吸链复合体Ⅰ与三磷酸腺苷（ATP）合酶活性和ATP含量；用蛋白质印迹法检测葡萄糖调节蛋白78（GRP78）和C/EBP同源蛋白（CHOP）等内质网应激标志蛋白、紧密连接蛋白1（ZO-1）、血管内皮钙黏蛋白（VE-cadherin）、ATP合酶F1亚基δ（ATP5D）的蛋白相对表达水平。
结果 对照组、模型组、实验组（0.1、1.0、10.0和100.0 μmol·L-1）的细胞活性分别为1.07±0.04，0.61±0.06，0.68±0.07，0.80±0.06，0.96±0.08和0.95±0.09，其中10 μmol·L-1浓度的保护效果最佳，后续实验均用此浓度。对照组、模型组、实验组的炎症因子IL-1β水平分别为（136.25±3.61），（200.12±8.56）和（149.50±9.20）ng·L-1，IL-6水平分别为（4.95±0.26），（8.96±0.60）和（6.23±0.34）ng·L-1，TNF-α水平分别为（328.66±19.14），（461.54±26.39）和（391.77±17.22）ng·L-1；内质网应激通路标志蛋白GRP78蛋白相对表达水平分别为0.84±0.15，1.45±0.13和0.82±0.15，CHOP蛋白相对表达水平分别为0.66±0.11，1.20±0.41和0.76±0.14，连接蛋白ZO-1相对表达水平分别为0.81±0.11，0.25±0.07和0.84±0.13，VE-cadherin蛋白相对表达水平分别为0.75±0.12，0.32±0.09和0.73±0.14，ATP5D蛋白相对表达水平分别为0.88±0.16，0.26±0.08和0.83±0.17，线粒体呼吸链复合体Ⅰ活性分别为2.12±0.26，1.40±0.17和1.82±0.15，ATP合酶活性分别为2.14±0.25，1.32±0.17和1.81±0.18，细胞内ATP含量分别为（86.32±8.50），（52.21±5.62）和（91.12±6.10）umol·ug-1protein，模型组的上述指标与对照组相比，实验组与模型组相比，在统计学上差异均有统计学意义（均P<0.05）。
结论 人参皂苷Rb1可能通过改善线粒体功能、增加细胞内ATP含量，减轻H/R诱导的HPECs损伤、炎症反应和内质网应激，最终恢复细胞正常功能。
, authors=李虹, 李欣怡, 刘钟桧, 欧阳雨晴, 付志方, 焦红梅, authorsList=李虹, 李欣怡, 刘钟桧, 欧阳雨晴, 付志方, 焦红梅, authorCompany=null, correspAuthors=付志方, authorNote=
李虹（1975-），女，副主任医师，主要从事老年医学方面的工作和研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=qfUosYUNxJpSXCVDW8ERig==, magXml=Nr/oh5wkTuysaCFje/Nd7g==, pdfUrl=null, pdf=6JAdQ3qC5AlilVGu/wKYnw==, pdfFileSize=1643227, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=k9tbwQIxAdNyPJoH0FEXmg==, mapNumber=null, fund=null)}, authors=[Author(id=1292130268454876008, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130268547150698, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130268454876008, language=EN, stringName=Hong LI, firstName=Hong, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130268987552619, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130268454876008, language=CN, stringName=李虹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学 第一医院 老年病内科，北京，100034, bio={"content":"
李虹（1975-），女，副主任医师，主要从事老年医学方面的工作和研究
"}, bioImg=null, bioContent=
李虹（1975-），女，副主任医师，主要从事老年医学方面的工作和研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130267720872803, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, xref=null, ext=[AuthorCompanyExt(id=1292130268014474084, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292130268035445605, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学 第一医院 老年病内科，北京，100034)])]), Author(id=1292130270732383085, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130271025984367, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130270732383085, language=EN, stringName=Xin-yi LI, firstName=Xin-yi, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130271156007792, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130270732383085, language=CN, stringName=李欣怡, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学 第一医院 老年病内科，北京，100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130267720872803, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, xref=null, ext=[AuthorCompanyExt(id=1292130268014474084, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292130268035445605, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学 第一医院 老年病内科，北京，100034)])]), Author(id=1292130271495746418, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130271982285684, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130271495746418, language=EN, stringName=Zhong-hui LIU, firstName=Zhong-hui, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130272070366069, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130271495746418, language=CN, stringName=刘钟桧, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学 第一医院 老年病内科，北京，100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130267720872803, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, xref=null, ext=[AuthorCompanyExt(id=1292130268014474084, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292130268035445605, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学 第一医院 老年病内科，北京，100034)])]), Author(id=1292130272359773047, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130272762426233, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130272359773047, language=EN, stringName=Yu-qing OUYANG, firstName=Yu-qing, middleName=null, lastName=OUYANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130273076999034, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130272359773047, language=CN, stringName=欧阳雨晴, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学 第一医院 老年病内科，北京，100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130267720872803, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, xref=null, ext=[AuthorCompanyExt(id=1292130268014474084, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292130268035445605, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学 第一医院 老年病内科，北京，100034)])]), Author(id=1292130273165079420, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=fuzhifang@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1292130275207705470, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130273165079420, language=EN, stringName=Zhi-fang FU, firstName=Zhi-fang, middleName=null, lastName=FU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130275618747263, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130273165079420, language=CN, stringName=付志方, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学 第一医院 老年病内科，北京，100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130267720872803, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, xref=null, ext=[AuthorCompanyExt(id=1292130268014474084, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292130268035445605, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学 第一医院 老年病内科，北京，100034)])]), Author(id=1292130276101092225, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130276864455555, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130276101092225, language=EN, stringName=Hong-mei JIAO, firstName=Hong-mei, middleName=null, lastName=JIAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130277711704964, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, authorId=1292130276101092225, language=CN, stringName=焦红梅, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=北京大学 第一医院 老年病内科，北京，100034, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130267720872803, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, xref=null, ext=[AuthorCompanyExt(id=1292130268014474084, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292130268035445605, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学 第一医院 老年病内科，北京，100034)])])], keywords=[Keyword(id=1292130278932247429, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=EN, orderNo=1, keyword=ginsenoside Rb1), Keyword(id=1292130280249258887, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=EN, orderNo=2, keyword=human pulmonary endothelial cell injury), Keyword(id=1292130280735798152, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=EN, orderNo=3, keyword=endoplasmic reticulum stress), Keyword(id=1292130281515938697, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=EN, orderNo=4, keyword=mitochondrial function), Keyword(id=1292130281977312138, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=EN, orderNo=5, keyword=adenosine triphosphate content), Keyword(id=1292130282346410891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=CN, orderNo=1, keyword=人参皂苷Rb1), Keyword(id=1292130282799395724, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=CN, orderNo=2, keyword=人肺血管内皮细胞损伤), Keyword(id=1292130284850410382, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=CN, orderNo=3, keyword=内质网应激), Keyword(id=1292130285328561039, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=CN, orderNo=4, keyword=线粒体功能), Keyword(id=1292130286129673104, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, language=CN, orderNo=5, keyword=三磷酸腺苷含量)], refs=null, funds=[Fund(id=1292130286960145297, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, awardId=null, language=CN, fundingSource=北京大学第一医院青年临床研究专项基金资助项目, fundOrder=null, country=null), Fund(id=1292130289044714386, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, awardId=null, language=CN, fundingSource=北京大学第一医院中西医协同旗舰医院建设试点项目—中西医协同团队立项基金资助项目, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1292130267720872803, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, xref=null, ext=[AuthorCompanyExt(id=1292130268014474084, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Geriatrics, Peking University First Hospital, Beijing 100034, China), AuthorCompanyExt(id=1292130268035445605, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130264776471390, companyId=1292130267720872803, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=北京大学 第一医院 老年病内科，北京，100034)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.08.016, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2026.08.016, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2026.08.016, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2026.08.016, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1777305600000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
103
19
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
