Article(id=1292130246204088834, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.08.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1768147200000, receivedDateStr=2026-01-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997457314, onlineDateStr=2026-08-06, pubDate=1777305600000, pubDateStr=2026-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997457314, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997457314, creator=13701087609, updateTime=1785997457314, updator=13701087609, issue=Issue{id=1292130221843571059, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1777305600000', pubDateStr='2026-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997451505, creator='13701087609', updateTime=1786014411018, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201355276480844, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201355276480845, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1101, endPage=1106, ext={EN=ArticleExt(id=1292130246434775555, articleId=1292130246204088834, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of azelastine hydrochloride combined with polyvinyl alcohol in the treatment of allergic conjunctivitis in children aged 4-6 years, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of azelastine hydrochloride eye drops combined with polyvinyl alcohol eye drops in the treatment of allergic conjunctivitis in children aged 4-6 years.
Methods Children with allergic conjunctivitis were divided into control group and treatment group based on the medication regimen. The control group received azelastine hydrochloride eye drops,1 drop each time, tid; while the treatment group received additional polyvinyl alcohol eye drops, 1 drop each time, tid. The treatment duration was 2 weeks. The two groups were compared in terms of clinical efficacy, comprehensive ocular symptom scores, tear film stability indicators, inflammatory factor levels, tear meniscus parameters and the incidence of adverse drug reactions were eveluated.
Results A total of 99 children were enrolled, including 48 cases in the control group and 51 cases in the treatment group. After treatment, the total effective rates in the treatment group and control group were 92.16% (47 cases/51 cases) and 89.58% (43 cases/48 cases), respectively, with no statistically significant difference between the two groups (P>0.05). After treatment, the scores for eye itching of the treatment group and the control group were (0.65±0.56) and (0.92±0.45) points, respectively; scores for foreign body sensation were (0.35±0.56) and (0.65±0.56) points, respectively; scores for tearing were (0.35±0.52) and (0.65±0.53) points, respectively; scores for photophobia were (0.37±0.49) and (0.63±0.57) points, respectively; the levels of hyaluronic acid (HA) were (85.58±9.36) and (90.69±10.58) μg·L-1, respectively; the levels of eosinophil cationic protein (ECP) were (6.36±0.89) and (6.82±0.95) μg·L-1, respectively; the levels of thymic stromal lymphopoietin (TSLP) were (7.57±1.59) and (8.43±1.48) pg·mL-1, respectively; the tear film breakup time (TBUT) were (11.49±1.37) and (10.83±1.19) s, respectively; the corneal fluorescein staining (CFS) score were (1.93±0.55) and (2.17±0.41) points, respectively; the lipid layer thickness (LLT) were (58.46±5.84) and (55.52±5.63) nm, respectively; the incomplete blink ratio (PBR) were (56.49±5.21) and (58.95±5.71)%, respectively; the meibomian gland dropout rate (MGDR) of the upper eyelids were (14.49±2.06)% and (15.36±1.88)%, respectively; MGDR of lower eyelids were (21.25±3.07)% and (22.87±2.79)%, respectively; the tear meniscus depth (TMD) were (219.64±24.56) and (208.65±23.57) μm, respectively; tear meniscus height (TMH) were (237.61±26.82) and (223.49±27.48)μm, respectively; tear meniscus area (TMA) were (58.49±8.33) and (55.07±8.11) μm2, respectively. For all the above parameters, the differences between the two groups were all statistically significant (all P<0.05). The total incidence of adverse drug reactions in the treatment group and control group was 5.88% (3 cases/51 cases) and 8.33% (4 cases/48 cases), respectively, with no statistically significant difference (P>0.05).
Conclusion The combination of azelastine hydrochloride eye drops and polyvinyl alcohol eye drops demonstrates good efficacy in treating allergic conjunctivitis in children aged 4-6 years, significantly improving ocular symptoms and tear film stability, reducing inflammatory markers, and without increasing adverse drug reactions.
, authors=Xiao-long HUANG, Ji-bing YU, Yang YANG, Xi-ya JIANG, authorsList=Xiao-long HUANG, Ji-bing YU, Yang YANG, Xi-ya JIANG, authorCompany=null, correspAuthors=Ji-bing YU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130246703211012, articleId=1292130246204088834, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=盐酸氮䓬斯汀联合聚乙烯醇治疗4~6周岁儿童过敏性结膜炎患儿的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察盐酸氮䓬斯汀滴眼液联合聚乙烯醇滴眼液治疗4~6周岁儿童过敏性结膜炎的临床疗效和安全性。
方法 将过敏性结膜炎患儿按用药方案分为对照组和试验组。对照组给予盐酸氮䓬斯汀滴眼液1滴/次，tid，试验组加用聚乙烯醇滴眼液1滴/次，tid，疗程均为2 w。比较2组患儿的临床疗效、眼部综合症状评分、泪膜稳定指标、炎症因子水平、泪河参数及药物不良反应发生情况。
结果 共纳入99例患儿，对照组48例，试验组51例。治疗后，试验组和对照组的总有效率分别为92.16%（47例/51例）和89.58%（43例/48例），在统计学上差异无统计学意义（P>0.05）。治疗后，试验组和对照组眼痒评分分别为（0.65±0.56）和（0.92±0.45）分，眼异物感评分分别为（0.35±0.56）和（0.65±0.56）分，流泪评分分别为（0.35±0.52）和（0.65±0.53）分，畏光评分分别为（0.37±0.49）和（0.63±0.57）分，试验组和对照组透明质酸（HA）分别为（85.58±9.36）和（90.69±10.58）μg·L-1，嗜酸细胞阳离子蛋白（ECP）分别为（6.36±0.89）和（6.82±0.95）μg·L-1，胸腺基质淋巴细胞生成素（TSLP）分别为（7.57±1.59）和（8.43±1.48）pg·mL-1，泪膜破裂时间（TBUT）分别为（11.49±1.37）和（10.83±1.19）s，角膜荧光素染色试验（CFS）评分分别为（1.93±0.55）和（2.17±0.41）分，泪膜脂质层厚度（LLT）分别为（58.46±5.84）和（55.52±5.63）nm，不完全瞬目比例（PBR）分别为（56.49±5.21）和（58.95±5.71）%，上睑睑板腺缺失率（MGDR）分别为（14.49±2.06）和（15.36±1.88）%，下睑睑板腺缺失率分别为（21.25±3.07）和（22.87±2.79）%，泪河深度（TMD）分别为（219.64±24.56）和（208.65±23.57）μm，泪河高度（TMH）分别为（237.61±26.82）和（223.49±27.48）μm，横截面面积（TMA）分别为（58.49±8.33）和（55.07±8.11）μm2；2组患者上述指标比较，在统计学上差异均有统计学意义（均P<0.05）。试验组和对照组的总药物不良反应发生率分别为5.88%（3例/51例）和8.33%（4例/48例），在统计学上差异无统计学意义（P>0.05）。
结论 盐酸氮䓬斯汀滴眼液联合聚乙烯醇滴眼液治疗4~6周岁儿童过敏性结膜炎疗效较好，可显著改善眼部症状、泪膜稳定性及降低炎症指标，且不增加药物不良反应。
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黄啸龙（1989-），男，主治医师，主要从事儿童眼科的临床工作和研究
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