Article(id=1292130233570849451, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.08.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1768147200000, receivedDateStr=2026-01-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997454301, onlineDateStr=2026-08-06, pubDate=1777305600000, pubDateStr=2026-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997454301, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997454301, creator=13701087609, updateTime=1785997454301, updator=13701087609, issue=Issue{id=1292130221843571059, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='8', pageStart='1051', pageEnd='1200', issueExtLink='null', onlineDate='null', pubDate='1777305600000', pubDateStr='2026-04-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997451505, creator='13701087609', updateTime=1786014411018, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201355276480844, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201355276480845, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130221843571059, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1070, endPage=1076, ext={EN=ArticleExt(id=1292130235714138796, articleId=1292130233570849451, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial on the treatment of children with idiopathic short stature by long-acting combined with vitamin D drops and lysine hydrochloride and calcium hydrogen phosphate, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To observe the efficacy of polyethylene glycol recombinant human growth hormone (PEG-rhGH) injection combined with vitamin D drops and lysine hydrochloride and calcium hydrogen phosphate granules in the treatment of children with idiopathic short stature (ISS).

Methods

Based on treatment regimen, children with ISS were categorized into treatment and control groups. Both groups received basic treatment of vitamin D drops (400-800 U daily) and lysine hydrochloride and calcium hydrogen phosphate granules (5 g, twice daily). The control group was given human somatropin injection at a dose of 0.10-0.20 IU·kg-1·d-1 by subcutaneous injection, while the treatment group was given PEG-rhGH injection at a dose of 0.20-0.40 mg·kg-1·w-1 by subcutaneous injection. Both groups received continuous medication for 12 months. The clinical efficacy, evaluation indicators of GH-insulin-like growth factor (IGF) axis function, bone metabolism indicators and safety were compared between the two groups.

Results

The study enrolled 79 cases, comprising 41 cases in the treatment group and 38 cases in the control group. After treatment, the effective rates of the treatment group and the control group were 95.12% (39 cases/41 cases) and 92.11% (35 cases/38 cases), respectively, with no statistically significant difference (P>0.05). After treatment, the levels of insulin-like growth factor-1/insulin-like growth factor binding protein-3 (IGF-1/IGFBP-3) in the treatment group and the control group were 0.08±0.02 and 0.07±0.02, respectively; the levels of liver-expressed antimicrobial peptide-2 (LEAP-2) were (1 395.69±187.26) pg·mL-1 and (1 487.58±195.48) pg·mL-1, respectively; the levels of osteocalcin (BGP) were (22.18±3.67) and (20.43±3.48) μg·L-1, respectively; procollagen I N-terminal peptide (PINP) were (602.68±63.41) and (574.08±61.83) μg·L-1, respectively; bone-specific alkaline phosphatase (BALP) was (192.68±23.64) and (203.41±22.18) U·L-1, respectively; vitamin D (Vit-D) were (20.39±3.47) and (18.65±3.62) ng·mL-1, respectively. Both indicators showed statistically significant differences between the two groups (all P<0.05). The incidences of adverse drug reactions of treatment group and the control group were 7.32% (3 cases/41 cases) and 10.53% (4 cases/38 case), with no statistically significant difference (P>0.05).

Conclusion

PEG-rhGH injection at a dose of 0.20-0.40 mg·kg-1·w-1 combined with vitamin D drops and lysine hydrochlodride and calcium hydrogen phosphate granules in the treatment of children with ISS can ensure efficacy and safety, while potentially achieving better long-term growth improvement effects. It can also improve the function of the GH-IGF axis and bone metabolism levels.

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目的

观察金培生长激素(PEG-rhGH)注射液联合维生素D滴剂及赖氨酸磷酸氢钙颗粒治疗特发性矮小症(ISS)患儿的临床疗效和安全性。

方法

将ISS患儿根据实际接受用药方案分为试验组和对照组。2组患儿均给予维生素D滴剂(日剂量400~800 U)及赖氨酸磷酸氢钙颗粒(每次5 g,每天2次)进行基础治疗。对照组在此基础上予人生长激素注射液0.10~0.20 IU·kg-1·d-1皮下注射,试验组在此基础上予金培生长激素注射液0.20~0.40 mg·kg-1·w-1皮下注射。治疗12个月。比较2组临床疗效、GH-胰岛素样生长因子(IGF)轴功能评估指标、骨代谢指标并进行安全性评价。

结果

共入组79例,试验组41例,对照组38例。试验组和对照组的有效率分别为95.12%(39例/41例)和92.11%(35例/38例),在统计学上差异无统计学意义(P>0.05)。治疗后,试验组和对照组的IGF-1/胰岛素样生长因子结合蛋白-3(IGFBP-3)分别为0.08±0.02和0.07±0.02,肝脏表达抗菌肽-2(LEAP-2)水平分别为(1 395.69±187.26)和(1 487.58±195.48)pg·mL-1,骨钙素(BGP)分别为(22.18±3.67)和(20.43±3.48)μg·L-1,Ⅰ型前胶原氨基端原肽(PINP)分别为(602.68±63.41)和(574.08±61.83)μg·L-1,骨源性碱性磷酸酶(BALP)分别为(192.68±23.64)和(203.41±22.18)U·L-1,维生素-D(Vit-D)分别为(20.39±3.47)和(18.65±3.62)ng·mL-1,上述指标2组间比较,在统计学上差异均有统计学意义(均P<0.05)。试验组和对照组的药物不良反应发生率分别为7.32%(3例/41例)和10.53%(4例/38例),在统计学上差异无统计学意义(P>0.05)。

结论

0.20~0.40 mg·kg-1·w-1 PEG-rhGH联合维生素D滴剂及赖氨酸磷酸氢钙颗粒治疗ISS患儿在保证疗效及安全性的同时,可能获得更优的长期生长改善效果,可改善GH-IGF轴功能及骨代谢水平。

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沈林云(1979-),男,主任医师,主要从事儿童内分泌疾病诊疗方面的工作和研究

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沈林云 MP: 13867628891 E-mail:
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长效生长激素联合维生素D及赖氨酸磷酸氢钙治疗特发性矮小症患儿的临床研究
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沈林云 , 李丽芳 , 汤巧巧
中国临床药理学杂志 | 临床与基础桥接研究 2026,42(8): 1070-1076
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中国临床药理学杂志 |临床与基础桥接研究 2026 , 42 (8) : 1070 -1076
长效生长激素联合维生素D及赖氨酸磷酸氢钙治疗特发性矮小症患儿的临床研究
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沈林云 , 李丽芳, 汤巧巧
作者信息
  • 浙江省台州医院 儿内科,浙江 台州 318050
通讯作者:
沈林云 MP: 13867628891 E-mail:
作者简介:

沈林云(1979-),男,主任医师,主要从事儿童内分泌疾病诊疗方面的工作和研究

Clinical trial on the treatment of children with idiopathic short stature by long-acting combined with vitamin D drops and lysine hydrochloride and calcium hydrogen phosphate
Lin-yun SHEN , Li-fang LI, Qiao-qiao TANG
Affiliations
  • Department of Pediatrics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, 318050, Zhejiang Province, China
出版时间: 2026-04-28 doi: 10.13699/j.cnki.1001-6821.2026.08.004
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目的

观察金培生长激素(PEG-rhGH)注射液联合维生素D滴剂及赖氨酸磷酸氢钙颗粒治疗特发性矮小症(ISS)患儿的临床疗效和安全性。

方法

将ISS患儿根据实际接受用药方案分为试验组和对照组。2组患儿均给予维生素D滴剂(日剂量400~800 U)及赖氨酸磷酸氢钙颗粒(每次5 g,每天2次)进行基础治疗。对照组在此基础上予人生长激素注射液0.10~0.20 IU·kg-1·d-1皮下注射,试验组在此基础上予金培生长激素注射液0.20~0.40 mg·kg-1·w-1皮下注射。治疗12个月。比较2组临床疗效、GH-胰岛素样生长因子(IGF)轴功能评估指标、骨代谢指标并进行安全性评价。

结果

共入组79例,试验组41例,对照组38例。试验组和对照组的有效率分别为95.12%(39例/41例)和92.11%(35例/38例),在统计学上差异无统计学意义(P>0.05)。治疗后,试验组和对照组的IGF-1/胰岛素样生长因子结合蛋白-3(IGFBP-3)分别为0.08±0.02和0.07±0.02,肝脏表达抗菌肽-2(LEAP-2)水平分别为(1 395.69±187.26)和(1 487.58±195.48)pg·mL-1,骨钙素(BGP)分别为(22.18±3.67)和(20.43±3.48)μg·L-1,Ⅰ型前胶原氨基端原肽(PINP)分别为(602.68±63.41)和(574.08±61.83)μg·L-1,骨源性碱性磷酸酶(BALP)分别为(192.68±23.64)和(203.41±22.18)U·L-1,维生素-D(Vit-D)分别为(20.39±3.47)和(18.65±3.62)ng·mL-1,上述指标2组间比较,在统计学上差异均有统计学意义(均P<0.05)。试验组和对照组的药物不良反应发生率分别为7.32%(3例/41例)和10.53%(4例/38例),在统计学上差异无统计学意义(P>0.05)。

结论

0.20~0.40 mg·kg-1·w-1 PEG-rhGH联合维生素D滴剂及赖氨酸磷酸氢钙颗粒治疗ISS患儿在保证疗效及安全性的同时,可能获得更优的长期生长改善效果,可改善GH-IGF轴功能及骨代谢水平。

金培生长激素注射液  /  维生素D滴剂  /  赖氨酸磷酸氢钙颗粒  /  特发性矮小症
Objective

To observe the efficacy of polyethylene glycol recombinant human growth hormone (PEG-rhGH) injection combined with vitamin D drops and lysine hydrochloride and calcium hydrogen phosphate granules in the treatment of children with idiopathic short stature (ISS).

Methods

Based on treatment regimen, children with ISS were categorized into treatment and control groups. Both groups received basic treatment of vitamin D drops (400-800 U daily) and lysine hydrochloride and calcium hydrogen phosphate granules (5 g, twice daily). The control group was given human somatropin injection at a dose of 0.10-0.20 IU·kg-1·d-1 by subcutaneous injection, while the treatment group was given PEG-rhGH injection at a dose of 0.20-0.40 mg·kg-1·w-1 by subcutaneous injection. Both groups received continuous medication for 12 months. The clinical efficacy, evaluation indicators of GH-insulin-like growth factor (IGF) axis function, bone metabolism indicators and safety were compared between the two groups.

Results

The study enrolled 79 cases, comprising 41 cases in the treatment group and 38 cases in the control group. After treatment, the effective rates of the treatment group and the control group were 95.12% (39 cases/41 cases) and 92.11% (35 cases/38 cases), respectively, with no statistically significant difference (P>0.05). After treatment, the levels of insulin-like growth factor-1/insulin-like growth factor binding protein-3 (IGF-1/IGFBP-3) in the treatment group and the control group were 0.08±0.02 and 0.07±0.02, respectively; the levels of liver-expressed antimicrobial peptide-2 (LEAP-2) were (1 395.69±187.26) pg·mL-1 and (1 487.58±195.48) pg·mL-1, respectively; the levels of osteocalcin (BGP) were (22.18±3.67) and (20.43±3.48) μg·L-1, respectively; procollagen I N-terminal peptide (PINP) were (602.68±63.41) and (574.08±61.83) μg·L-1, respectively; bone-specific alkaline phosphatase (BALP) was (192.68±23.64) and (203.41±22.18) U·L-1, respectively; vitamin D (Vit-D) were (20.39±3.47) and (18.65±3.62) ng·mL-1, respectively. Both indicators showed statistically significant differences between the two groups (all P<0.05). The incidences of adverse drug reactions of treatment group and the control group were 7.32% (3 cases/41 cases) and 10.53% (4 cases/38 case), with no statistically significant difference (P>0.05).

Conclusion

PEG-rhGH injection at a dose of 0.20-0.40 mg·kg-1·w-1 combined with vitamin D drops and lysine hydrochlodride and calcium hydrogen phosphate granules in the treatment of children with ISS can ensure efficacy and safety, while potentially achieving better long-term growth improvement effects. It can also improve the function of the GH-IGF axis and bone metabolism levels.

polyethylene glycol recombinant human growth hormone injection  /  vitamin D drops  /  lysine hydrochloride and calcium hydrogen phosphate granules  /  idiopathic short stature
沈林云, 李丽芳, 汤巧巧. 长效生长激素联合维生素D及赖氨酸磷酸氢钙治疗特发性矮小症患儿的临床研究. 中国临床药理学杂志, 2026 , 42 (8) : 1070 -1076 . DOI: 10.13699/j.cnki.1001-6821.2026.08.004
Lin-yun SHEN, Li-fang LI, Qiao-qiao TANG. Clinical trial on the treatment of children with idiopathic short stature by long-acting combined with vitamin D drops and lysine hydrochloride and calcium hydrogen phosphate[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (8) : 1070 -1076 . DOI: 10.13699/j.cnki.1001-6821.2026.08.004

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doi: 10.13699/j.cnki.1001-6821.2026.08.004
  • 接收时间:2026-01-12
  • 首发时间:2026-08-06
  • 出版时间:2026-04-28
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  • 收稿日期:2026-01-12
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    浙江省台州医院 儿内科,浙江 台州 318050

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沈林云 MP: 13867628891 E-mail:
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2种不同金属材料的力学参数

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Genus
种数
Number of
species
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species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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