Article(id=1292130374973415430, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.06.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1773763200000, receivedDateStr=2026-03-18, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997488015, onlineDateStr=2026-08-06, pubDate=1774627200000, pubDateStr=2026-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997488015, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997488015, creator=13701087609, updateTime=1785997488015, updator=13701087609, issue=Issue{id=1292130360968630762, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1774627200000', pubDateStr='2026-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997484675, creator='13701087609', updateTime=1786014452071, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201527440068743, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201527440068744, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=764, endPage=769, ext={EN=ArticleExt(id=1292130375187324935, articleId=1292130374973415430, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Efficacy of tranexamic acid combined with phloroglucinol in fetal protection for threatened abortion, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To investigate the efficacy of tranexamic acid combined with phloroglucinol in fetal protection for threatened abortion and its impact on pregnancy outcome.

Methods

Patients with threatened abortion were divided into control group and treatment group according to the treatment methods. Both groups received routine fetal protection treatment. The control group was given intravenous infusion of tranexamic acid on the basis of routine treatment. The patients in the treatment group were additionally given intravenous infusion of phloroglucinol on the basis of the treatment of the control group. The clinical efficacy, remission time of clinical symptoms, uterine hemodynamics, sex hormone levels, pregnancy outcomes, and safety evaluation of the two groups were assessed.

Results

A total of 82 cases were enrolled in this study, including 39 cases in the control group and 43 cases in the treatment group. The fetal protection success rates were 71.79% and 90.70% in the control and treatment groups, respectively, with statistically significant difference (P<0.05). The waist soreness relief time was (3.64±0.71) d in the control group and (3.26±0.62) d in the treatment group; the lower abdominal dragging pain relief time was (2.90±0.50) d and (2.65±0.53) d, respectively; and the vaginal bleeding relief time was (3.00±0.61) d and (2.72±0.59) d, respectively. After treatment, the resistance index (RI) was 0.83±0.16 and 0.76±0.14; the pulsatility index (PI) was 2.46±0.65 and 2.12±0.41, respectively; and the systolic/diastolic ratio (S/D) was 3.24±0.54 and 2.98±0.48 in the control and treatment groups, respectively. The progesterone (P) levels were (99.40±8.63) and (104.11±8.97) nmol·L-1, respectively; the estradiol (E2) levels were (982.73±82.77) and (1 027.18±79.41) pmol·L-1, respectively; and the β-human chorionic gonadotropin (β-hCG) levels were (77 695.54±10 728.91) and (85 684.63±11 755.83) mIU·mL-1 in the control and treatment groups, respectively. The abortion rates were 23.08% and 6.98%, and the term delivery rates were 61.54% and 88.37% in the two groups, respectively. The differences in the above indicators between the two groups were statistically significant (all P<0.05). During the treatment period, headache or diarrhea occurred in both groups, with total incidence rates of 7.69% and 4.65%, respectively, and the difference was not statistically significant (P>0.05).

Conclusion

The combined use of tranexamic acid and phloroglucinol in patients with threatened abortion can accelerate the relief of clinical symptoms, improve the success rate of fetal protection, and improve pregnancy outcomes, with no significant increase in adverse events observed.

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目的

探究氨甲环酸联合间苯三酚在先兆流产的保胎效果及对妊娠结局的影响。

方法

将先兆流产患者根据治疗方法分为对照组与试验组。2组患者均给予常规保胎治疗。对照组在常规治疗基础上予以氨甲环酸静脉滴注。试验组患者在对照组基础上加用间苯三酚静脉滴注。评估2组患者临床疗效、临床症状缓解时间、子宫血流动力学、性激素水平、妊娠结局、安全性。

结果

本研究入组82例,其中对照组39例,试验组43例。对照组和试验组的保胎成功率分别为71.79%和90.70%,差异有统计学意义(P<0.05)。对照组和试验组的腰部酸痛缓解时间分别为(3.64±0.71)和(3.26±0.62)d,小腹坠痛缓解时间分别为(2.90±0.50)和(2.65±0.53)d,阴道出血缓解时间分别为(3.00±0.61)和(2.72±0.59)d,治疗后阻力指数(RI)分别为0.83±0.16和0.76±0.14,搏动指数(PI)分别为2.46±0.65和2.12±0.41,收缩期/舒张期比值(S/D)分别为(3.24±0.54)和(2.98±0.48),孕酮(P)水平分别为(99.40±8.63)和(104.11±8.97)nmol·L-1,雌二醇(E2)水平分别为(982.73±82.77)和(1 027.18±79.41)pmol·L-1,β-人绒毛膜促性腺激素(β-hCG)水平分别为(77 695.54±10 728.91)和(85 684.63±11 755.83)mIU·mL-1,流产率分别为23.08%和6.98%,足月分娩率分别为61.54%和88.37%,2组上述指标比较,在统计学上差异均有统计学意义(均P<0.05)。治疗期间,对照组和试验组均发生头痛或腹泻,总发生率分别为7.69%和4.65%,差异无统计学意义(P>0.05)。

结论

在先兆流产患者中使用氨甲环酸联合间苯三酚治疗,可加速缓解患者临床症状,提升保胎成功率,改善妊娠结局,且未见明显不良反应增加。

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许莉(1988-),女,主治医师,主要从事妇产科方面的工作研究

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许莉 MP: 15105827175 E-mail:
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氨甲环酸联合间苯三酚治疗先兆流产的临床研究
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许莉 a , 沈佳燕 b , 胡刚 c
中国临床药理学杂志 | 临床与基础桥接研究 2026,42(6): 764-769
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中国临床药理学杂志 |临床与基础桥接研究 2026 , 42 (6) : 764 -769
氨甲环酸联合间苯三酚治疗先兆流产的临床研究
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许莉(1988-),女,主治医师,主要从事妇产科方面的工作研究

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许莉a , 沈佳燕b, 胡刚c
作者信息
  • a.湖州市妇幼保健院,妇产科,浙江 湖州 313000
  • b.湖州市妇幼保健院,生殖中心,浙江 湖州 313000
  • c.湖州市妇幼保健院,产科,浙江 湖州 313000
通讯作者:
许莉 MP: 15105827175 E-mail:
作者简介:

许莉(1988-),女,主治医师,主要从事妇产科方面的工作研究

Efficacy of tranexamic acid combined with phloroglucinol in fetal protection for threatened abortion
Li XUa , Jia-yan SHENb, Gang HUc
Affiliations
  • a.Obstetrics and Gynecology, Huzhou Maternity & Child Health Care Hospital, Huzhou 313000, Zhejiang Province, China
  • b.Reproductive Center, Huzhou Maternity & Child Health Care Hospital, Huzhou 313000, Zhejiang Province, China
  • c.Obstetrics, Huzhou Maternity & Child Health Care Hospital, Huzhou 313000, Zhejiang Province, China
出版时间: 2026-03-28 doi: 10.13699/j.cnki.1001-6821.2026.06.003
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目的

探究氨甲环酸联合间苯三酚在先兆流产的保胎效果及对妊娠结局的影响。

方法

将先兆流产患者根据治疗方法分为对照组与试验组。2组患者均给予常规保胎治疗。对照组在常规治疗基础上予以氨甲环酸静脉滴注。试验组患者在对照组基础上加用间苯三酚静脉滴注。评估2组患者临床疗效、临床症状缓解时间、子宫血流动力学、性激素水平、妊娠结局、安全性。

结果

本研究入组82例,其中对照组39例,试验组43例。对照组和试验组的保胎成功率分别为71.79%和90.70%,差异有统计学意义(P<0.05)。对照组和试验组的腰部酸痛缓解时间分别为(3.64±0.71)和(3.26±0.62)d,小腹坠痛缓解时间分别为(2.90±0.50)和(2.65±0.53)d,阴道出血缓解时间分别为(3.00±0.61)和(2.72±0.59)d,治疗后阻力指数(RI)分别为0.83±0.16和0.76±0.14,搏动指数(PI)分别为2.46±0.65和2.12±0.41,收缩期/舒张期比值(S/D)分别为(3.24±0.54)和(2.98±0.48),孕酮(P)水平分别为(99.40±8.63)和(104.11±8.97)nmol·L-1,雌二醇(E2)水平分别为(982.73±82.77)和(1 027.18±79.41)pmol·L-1,β-人绒毛膜促性腺激素(β-hCG)水平分别为(77 695.54±10 728.91)和(85 684.63±11 755.83)mIU·mL-1,流产率分别为23.08%和6.98%,足月分娩率分别为61.54%和88.37%,2组上述指标比较,在统计学上差异均有统计学意义(均P<0.05)。治疗期间,对照组和试验组均发生头痛或腹泻,总发生率分别为7.69%和4.65%,差异无统计学意义(P>0.05)。

结论

在先兆流产患者中使用氨甲环酸联合间苯三酚治疗,可加速缓解患者临床症状,提升保胎成功率,改善妊娠结局,且未见明显不良反应增加。

间苯三酚  /  氨甲环酸  /  先兆流产  /  妊娠结局  /  孕酮
Objective

To investigate the efficacy of tranexamic acid combined with phloroglucinol in fetal protection for threatened abortion and its impact on pregnancy outcome.

Methods

Patients with threatened abortion were divided into control group and treatment group according to the treatment methods. Both groups received routine fetal protection treatment. The control group was given intravenous infusion of tranexamic acid on the basis of routine treatment. The patients in the treatment group were additionally given intravenous infusion of phloroglucinol on the basis of the treatment of the control group. The clinical efficacy, remission time of clinical symptoms, uterine hemodynamics, sex hormone levels, pregnancy outcomes, and safety evaluation of the two groups were assessed.

Results

A total of 82 cases were enrolled in this study, including 39 cases in the control group and 43 cases in the treatment group. The fetal protection success rates were 71.79% and 90.70% in the control and treatment groups, respectively, with statistically significant difference (P<0.05). The waist soreness relief time was (3.64±0.71) d in the control group and (3.26±0.62) d in the treatment group; the lower abdominal dragging pain relief time was (2.90±0.50) d and (2.65±0.53) d, respectively; and the vaginal bleeding relief time was (3.00±0.61) d and (2.72±0.59) d, respectively. After treatment, the resistance index (RI) was 0.83±0.16 and 0.76±0.14; the pulsatility index (PI) was 2.46±0.65 and 2.12±0.41, respectively; and the systolic/diastolic ratio (S/D) was 3.24±0.54 and 2.98±0.48 in the control and treatment groups, respectively. The progesterone (P) levels were (99.40±8.63) and (104.11±8.97) nmol·L-1, respectively; the estradiol (E2) levels were (982.73±82.77) and (1 027.18±79.41) pmol·L-1, respectively; and the β-human chorionic gonadotropin (β-hCG) levels were (77 695.54±10 728.91) and (85 684.63±11 755.83) mIU·mL-1 in the control and treatment groups, respectively. The abortion rates were 23.08% and 6.98%, and the term delivery rates were 61.54% and 88.37% in the two groups, respectively. The differences in the above indicators between the two groups were statistically significant (all P<0.05). During the treatment period, headache or diarrhea occurred in both groups, with total incidence rates of 7.69% and 4.65%, respectively, and the difference was not statistically significant (P>0.05).

Conclusion

The combined use of tranexamic acid and phloroglucinol in patients with threatened abortion can accelerate the relief of clinical symptoms, improve the success rate of fetal protection, and improve pregnancy outcomes, with no significant increase in adverse events observed.

phloroglucinol  /  tranexamic acid  /  threatened abortion  /  pregnancy outcome  /  progesterone
许莉, 沈佳燕, 胡刚. 氨甲环酸联合间苯三酚治疗先兆流产的临床研究. 中国临床药理学杂志, 2026 , 42 (6) : 764 -769 . DOI: 10.13699/j.cnki.1001-6821.2026.06.003
Li XU, Jia-yan SHEN, Gang HU. Efficacy of tranexamic acid combined with phloroglucinol in fetal protection for threatened abortion[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (6) : 764 -769 . DOI: 10.13699/j.cnki.1001-6821.2026.06.003
  • 湖州市科学技术局公益性应用研究项目(2022GY43)
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2026年第42卷第6期
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doi: 10.13699/j.cnki.1001-6821.2026.06.003
  • 接收时间:2026-03-18
  • 首发时间:2026-08-06
  • 出版时间:2026-03-28
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  • 收稿日期:2026-03-18
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湖州市科学技术局公益性应用研究项目(2022GY43)
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    a.湖州市妇幼保健院,妇产科,浙江 湖州 313000
    b.湖州市妇幼保健院,生殖中心,浙江 湖州 313000
    c.湖州市妇幼保健院,产科,浙江 湖州 313000

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许莉 MP: 15105827175 E-mail:
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2种不同金属材料的力学参数

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Genus
种数
Number of
species
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Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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