Article(id=1292130391272477376, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.06.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1739203200000, receivedDateStr=2025-02-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997491900, onlineDateStr=2026-08-06, pubDate=1774627200000, pubDateStr=2026-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997491900, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997491900, creator=13701087609, updateTime=1785997491900, updator=13701087609, issue=Issue{id=1292130360968630762, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1774627200000', pubDateStr='2026-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997484675, creator='13701087609', updateTime=1786014452071, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201527440068743, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201527440068744, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=759, endPage=763, ext={EN=ArticleExt(id=1292130391457026753, articleId=1292130391272477376, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism and its impact on thyroid function, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore and analyze the efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism, its impact on thyroid function.
Methods Patients with hyperthyroidism were collected and assigned into treatment group and control group. The control group was treated with iodine-131 alone; the treatment group was treated with a combination of propranolol and iodine-131. The efficacy, anxiety (self-rating anxiety scale, SAS) scores and depression (self-rating depression scale, SDS) scores, thyroid hormone levels, cardiac function indicators, and adverse reactions were compared between the two groups.
Results A total of 160 patients were enrolled, with 80 cases in each group. There was no significant difference in efficacy between the treatment group and the control group (P>0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). After treatment, the SAS score, SDS score, free triiodothyronine (FT3) level, free thyroxine (FT4) level, left ventricular ejection fraction (LVEF) level, stroke volume (SV) level, heart rate level in both groups decreased, and the treatment group was lower than the control group (all P<0.05); the TSH level increased, and the treatment group was higher than the control group (P<0.05).
Conclusion Compared with the use of iodine-131 alone, the combined treatment of propranolol and iodine-131 for hyperthyroidism can effectively improve thyroid function and cardiac function, and reduce anxiety and depression in patients.
, authors=Xiu-xiu GAO, Xing ZHANG, Juan LI, authorsList=Xiu-xiu GAO, Xing ZHANG, Juan LI, authorCompany=null, correspAuthors=Juan LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130391729656514, articleId=1292130391272477376, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究分析普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响。
方法 将甲亢患者,分为试验组和对照组。对照组单用碘-131治疗;试验组联合使用普萘洛尔和碘-131治疗。比较两组患者的临床疗效、焦虑(焦虑自评量表,SAS)抑郁(抑郁自评量表,SDS)评分、甲状腺激素水平、心功能指标和不良反应发生情况。
结果 共入选160例患者,对照组和试验组各80例,试验组与对照组疗效无显著差异(P>0.05)。不良反应在2组间差异不显著(P>0.05)。治疗后,2组SAS评分、SDS评分、游离三碘甲腺原氨酸(FT3)水平、游离甲状腺素(FT4)水平、左心室射血分数(LVEF)水平、每搏输出量(SV)水平、心率水平均降低,且试验组低于对照组(P<0.05);TSH水平升高,试验组高于对照组(P<0.05)。
结论 与单独使用碘-131相比,普萘洛尔和碘-131联合治疗甲状腺功能亢进症能有效改善甲状腺功能和心功能,降低患者焦虑抑郁情况。
, authors=高秀秀, 张星, 李娟, authorsList=高秀秀, 张星, 李娟, authorCompany=null, correspAuthors=李娟, authorNote=
高秀秀(1987-),女,主管药师,主要从事放射性药物研究
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