Article(id=1292130391272477376, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.06.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1739203200000, receivedDateStr=2025-02-11, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997491900, onlineDateStr=2026-08-06, pubDate=1774627200000, pubDateStr=2026-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997491900, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997491900, creator=13701087609, updateTime=1785997491900, updator=13701087609, issue=Issue{id=1292130360968630762, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1774627200000', pubDateStr='2026-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997484675, creator='13701087609', updateTime=1786014452071, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201527440068743, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201527440068744, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130360968630762, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=759, endPage=763, ext={EN=ArticleExt(id=1292130391457026753, articleId=1292130391272477376, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism and its impact on thyroid function, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective

To explore and analyze the efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism, its impact on thyroid function.

Methods

Patients with hyperthyroidism were collected and assigned into treatment group and control group. The control group was treated with iodine-131 alone; the treatment group was treated with a combination of propranolol and iodine-131. The efficacy, anxiety (self-rating anxiety scale, SAS) scores and depression (self-rating depression scale, SDS) scores, thyroid hormone levels, cardiac function indicators, and adverse reactions were compared between the two groups.

Results

A total of 160 patients were enrolled, with 80 cases in each group. There was no significant difference in efficacy between the treatment group and the control group (P>0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). After treatment, the SAS score, SDS score, free triiodothyronine (FT3) level, free thyroxine (FT4) level, left ventricular ejection fraction (LVEF) level, stroke volume (SV) level, heart rate level in both groups decreased, and the treatment group was lower than the control group (all P<0.05); the TSH level increased, and the treatment group was higher than the control group (P<0.05).

Conclusion

Compared with the use of iodine-131 alone, the combined treatment of propranolol and iodine-131 for hyperthyroidism can effectively improve thyroid function and cardiac function, and reduce anxiety and depression in patients.

, authors=Xiu-xiu GAO, Xing ZHANG, Juan LI, authorsList=Xiu-xiu GAO, Xing ZHANG, Juan LI, authorCompany=null, correspAuthors=Juan LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130391729656514, articleId=1292130391272477376, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的

探究分析普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响。

方法

将甲亢患者,分为试验组和对照组。对照组单用碘-131治疗;试验组联合使用普萘洛尔和碘-131治疗。比较两组患者的临床疗效、焦虑(焦虑自评量表,SAS)抑郁(抑郁自评量表,SDS)评分、甲状腺激素水平、心功能指标和不良反应发生情况。

结果

共入选160例患者,对照组和试验组各80例,试验组与对照组疗效无显著差异(P>0.05)。不良反应在2组间差异不显著(P>0.05)。治疗后,2组SAS评分、SDS评分、游离三碘甲腺原氨酸(FT3)水平、游离甲状腺素(FT4)水平、左心室射血分数(LVEF)水平、每搏输出量(SV)水平、心率水平均降低,且试验组低于对照组(P<0.05);TSH水平升高,试验组高于对照组(P<0.05)。

结论

与单独使用碘-131相比,普萘洛尔和碘-131联合治疗甲状腺功能亢进症能有效改善甲状腺功能和心功能,降低患者焦虑抑郁情况。

, authors=高秀秀, 张星, 李娟, authorsList=高秀秀, 张星, 李娟, authorCompany=null, correspAuthors=李娟, authorNote=

高秀秀(1987-),女,主管药师,主要从事放射性药物研究

, correspAuthorsNote=
李娟,主治医师 MP: 19829220648 E-mail:
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=xqIfG4QCoveam5UEs7vSsg==, magXml=ARlrmi2pecjzP9rFggX/4w==, pdfUrl=null, pdf=nvBpOp3SIWLV8f7xRhRMeg==, pdfFileSize=1593325, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=uvFQSwc8j2H+Hc04qTeKEQ==, mapNumber=null, fund=null)}, authors=[Author(id=1292130392031646409, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130392144892619, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392031646409, language=EN, stringName=Xiu-xiu GAO, firstName=Xiu-xiu, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130392216195788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392031646409, language=CN, stringName=高秀秀, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=榆林市第一医院 核医学科,陕西 榆林 719000, bio={"content":"

高秀秀(1987-),女,主管药师,主要从事放射性药物研究

"}, bioImg=null, bioContent=

高秀秀(1987-),女,主管药师,主要从事放射性药物研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130391926788804, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, xref=null, ext=[AuthorCompanyExt(id=1292130391930983109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China), AuthorCompanyExt(id=1292130391939371718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=榆林市第一医院 核医学科,陕西 榆林 719000)])]), Author(id=1292130392300081871, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130392388162257, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392300081871, language=EN, stringName=Xing ZHANG, firstName=Xing, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130392467854034, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392300081871, language=CN, stringName=张星, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=榆林市第一医院 核医学科,陕西 榆林 719000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130391926788804, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, xref=null, ext=[AuthorCompanyExt(id=1292130391930983109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China), AuthorCompanyExt(id=1292130391939371718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=榆林市第一医院 核医学科,陕西 榆林 719000)])]), Author(id=1292130392560128724, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1147552142@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1292130392673374934, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392560128724, language=EN, stringName=Juan LI, firstName=Juan, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130392786621143, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392560128724, language=CN, stringName=李娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=榆林市第一医院 核医学科,陕西 榆林 719000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130391926788804, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, xref=null, ext=[AuthorCompanyExt(id=1292130391930983109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China), AuthorCompanyExt(id=1292130391939371718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=榆林市第一医院 核医学科,陕西 榆林 719000)])])], keywords=[Keyword(id=1292130392946004696, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=EN, orderNo=1, keyword=propranolol), Keyword(id=1292130393013113563, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=EN, orderNo=2, keyword=radiopharmaceutical iodine-131), Keyword(id=1292130393206051549, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=EN, orderNo=3, keyword=hyperthyroidism), Keyword(id=1292130393277354718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=EN, orderNo=4, keyword=thyroid hormone), Keyword(id=1292130393591927519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=EN, orderNo=5, keyword=cardiac function), Keyword(id=1292130395085099744, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=CN, orderNo=1, keyword=普萘洛尔), Keyword(id=1292130395164791522, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=CN, orderNo=2, keyword=放射性药物碘-131), Keyword(id=1292130395240288995, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=CN, orderNo=3, keyword=甲状腺功能亢进症), Keyword(id=1292130395307397860, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=CN, orderNo=4, keyword=甲状腺激素), Keyword(id=1292130395370312421, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, language=CN, orderNo=5, keyword=心功能)], refs=null, funds=[Fund(id=1292130395496141542, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, awardId=20210362, language=CN, fundingSource=榆林市科技计划资助项目(20210362), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1292130391926788804, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, xref=null, ext=[AuthorCompanyExt(id=1292130391930983109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China), AuthorCompanyExt(id=1292130391939371718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=榆林市第一医院 核医学科,陕西 榆林 719000)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.06.002, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2026.06.002, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2026.06.002, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2026.06.002, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1774627200000, fullTextJson=null, articleText=null, reference=null)
收藏切换
普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响
收藏切换
PDF下载
高秀秀 , 张星 , 李娟
中国临床药理学杂志 | 临床与基础桥接研究 2026,42(6): 759-763
收起
收藏切换
中国临床药理学杂志 |临床与基础桥接研究 2026 , 42 (6) : 759 -763
普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响
全屏
[Author(id=1292130392031646409, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130392144892619, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392031646409, language=EN, stringName=Xiu-xiu GAO, firstName=Xiu-xiu, middleName=null, lastName=GAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130392216195788, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392031646409, language=CN, stringName=高秀秀, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=榆林市第一医院 核医学科,陕西 榆林 719000, bio={"content":"

高秀秀(1987-),女,主管药师,主要从事放射性药物研究

"}, bioImg=null, bioContent=

高秀秀(1987-),女,主管药师,主要从事放射性药物研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130391926788804, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, xref=null, ext=[AuthorCompanyExt(id=1292130391930983109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China), AuthorCompanyExt(id=1292130391939371718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=榆林市第一医院 核医学科,陕西 榆林 719000)])]), Author(id=1292130392300081871, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292130392388162257, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392300081871, language=EN, stringName=Xing ZHANG, firstName=Xing, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130392467854034, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392300081871, language=CN, stringName=张星, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=榆林市第一医院 核医学科,陕西 榆林 719000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130391926788804, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, xref=null, ext=[AuthorCompanyExt(id=1292130391930983109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China), AuthorCompanyExt(id=1292130391939371718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=榆林市第一医院 核医学科,陕西 榆林 719000)])]), Author(id=1292130392560128724, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1147552142@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1292130392673374934, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392560128724, language=EN, stringName=Juan LI, firstName=Juan, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292130392786621143, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, authorId=1292130392560128724, language=CN, stringName=李娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=榆林市第一医院 核医学科,陕西 榆林 719000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292130391926788804, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, xref=null, ext=[AuthorCompanyExt(id=1292130391930983109, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China), AuthorCompanyExt(id=1292130391939371718, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292130391272477376, companyId=1292130391926788804, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=榆林市第一医院 核医学科,陕西 榆林 719000)])])]
高秀秀, 张星, 李娟
作者信息
  • 榆林市第一医院 核医学科,陕西 榆林 719000
通讯作者:
李娟,主治医师 MP: 19829220648 E-mail:
作者简介:

高秀秀(1987-),女,主管药师,主要从事放射性药物研究

Efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism and its impact on thyroid function
Xiu-xiu GAO, Xing ZHANG, Juan LI
Affiliations
  • Department of Nuclear Medicine, The First Hospital of Yulin, Yulin 719000, Shaanxi Province, China
出版时间: 2026-03-28 doi: 10.13699/j.cnki.1001-6821.2026.06.002
文章导航
收藏切换
目的

探究分析普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响。

方法

将甲亢患者,分为试验组和对照组。对照组单用碘-131治疗;试验组联合使用普萘洛尔和碘-131治疗。比较两组患者的临床疗效、焦虑(焦虑自评量表,SAS)抑郁(抑郁自评量表,SDS)评分、甲状腺激素水平、心功能指标和不良反应发生情况。

结果

共入选160例患者,对照组和试验组各80例,试验组与对照组疗效无显著差异(P>0.05)。不良反应在2组间差异不显著(P>0.05)。治疗后,2组SAS评分、SDS评分、游离三碘甲腺原氨酸(FT3)水平、游离甲状腺素(FT4)水平、左心室射血分数(LVEF)水平、每搏输出量(SV)水平、心率水平均降低,且试验组低于对照组(P<0.05);TSH水平升高,试验组高于对照组(P<0.05)。

结论

与单独使用碘-131相比,普萘洛尔和碘-131联合治疗甲状腺功能亢进症能有效改善甲状腺功能和心功能,降低患者焦虑抑郁情况。

普萘洛尔  /  放射性药物碘-131  /  甲状腺功能亢进症  /  甲状腺激素  /  心功能
Objective

To explore and analyze the efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism, its impact on thyroid function.

Methods

Patients with hyperthyroidism were collected and assigned into treatment group and control group. The control group was treated with iodine-131 alone; the treatment group was treated with a combination of propranolol and iodine-131. The efficacy, anxiety (self-rating anxiety scale, SAS) scores and depression (self-rating depression scale, SDS) scores, thyroid hormone levels, cardiac function indicators, and adverse reactions were compared between the two groups.

Results

A total of 160 patients were enrolled, with 80 cases in each group. There was no significant difference in efficacy between the treatment group and the control group (P>0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). After treatment, the SAS score, SDS score, free triiodothyronine (FT3) level, free thyroxine (FT4) level, left ventricular ejection fraction (LVEF) level, stroke volume (SV) level, heart rate level in both groups decreased, and the treatment group was lower than the control group (all P<0.05); the TSH level increased, and the treatment group was higher than the control group (P<0.05).

Conclusion

Compared with the use of iodine-131 alone, the combined treatment of propranolol and iodine-131 for hyperthyroidism can effectively improve thyroid function and cardiac function, and reduce anxiety and depression in patients.

propranolol  /  radiopharmaceutical iodine-131  /  hyperthyroidism  /  thyroid hormone  /  cardiac function
高秀秀, 张星, 李娟. 普萘洛尔联合放射性药物碘-131治疗甲状腺功能亢进症的临床疗效及对甲状腺功能的影响. 中国临床药理学杂志, 2026 , 42 (6) : 759 -763 . DOI: 10.13699/j.cnki.1001-6821.2026.06.002
Xiu-xiu GAO, Xing ZHANG, Juan LI. Efficacy of propranolol combined with Radiopharmaceutical iodine-131 in treating hyperthyroidism and its impact on thyroid function[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (6) : 759 -763 . DOI: 10.13699/j.cnki.1001-6821.2026.06.002
  • 榆林市科技计划资助项目(20210362)
参考文献 引证文献
排序方式:
2026年第42卷第6期
PDF下载
135
21
引用本文
BibTeX
文章信息
doi: 10.13699/j.cnki.1001-6821.2026.06.002
  • 接收时间:2025-02-11
  • 首发时间:2026-08-06
  • 出版时间:2026-03-28
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期:2025-02-11
基金
榆林市科技计划资助项目(20210362)
作者信息
    榆林市第一医院 核医学科,陕西 榆林 719000

通讯作者:

李娟,主治医师 MP: 19829220648 E-mail:
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.06.002
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏