Article(id=1292130419034583766, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.05.022, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785997498519, onlineDateStr=2026-08-06, pubDate=1773676800000, pubDateStr=2026-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785997498519, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785997498519, creator=13701087609, updateTime=1785997498519, updator=13701087609, issue=Issue{id=1292130254689165893, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1773676800000', pubDateStr='2026-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785997459337, creator='13701087609', updateTime=1786014469153, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201599108141219, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201599108141220, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292130254689165893, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=739, endPage=745, ext={EN=ArticleExt(id=1292130419265270487, articleId=1292130419034583766, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status on antibacterial activity, pharmacokinetics and clinical applications of sitafloxacin, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Sitafloxacin, a fourth-generation fluoroquinolone antibacterial agent, exerts potent antibacterial activity against gram-negative and gram-positive bacteria, atypical pathogens and anaerobic bacteria. It also remains effective against fluoroquinolone-resistant strains, methicillin-resistant Staphylococcus aureus, penicillin-insensitive Streptococcus pneumoniae and Enterococcus. It is widely used clinically for treating infectious diseases such as upper and lower respiratory tract infections, genitourinary infections, oral infections and otitis media. Sitafloxacin shows linear pharmacokinetic characteristics within the dose range of 50-200 mg. It is rapidly absorbed after oral administration, widely distributed in various tissues and organs throughout the body, and mainly excreted in the urine as unchanged form. Commonly reported adverse events include diarrhea, nausea and abnormal liver function. In recent years, studies have found that sitafloxacin is also effective against multidrug-resistant pathogens causing ventilator-associated pneumonia, hospital-acquired pneumonia, tuberculosis, Mycoplasma genitalium infections in men, Mycobacterium abscessus infection periodontal infection, Helicobacter pylori infections and refractory Mycobacterium skin infections. However, further clinical studies are still needed to evaluate its efficacy and safety, and pharmacokinetic studies should be conducted in special populations such as the elderly and those with hepatic impairment. This article systematically reviews the pharmacological mechanism, antibacterial activity, pharmacokinetic/pharmacodynamic characteristics and recent advances in clinical research of sitafloxacin, aiming to provide a reference basis for the safe and effective clinical use of sitafloxacin.

, authors=Ying-ying PANG¹, Wen-yan LI², Yan LU², Jing DONG², authorsList=Ying-ying PANG, Wen-yan LI, Yan LU, Jing DONG, authorCompany=null, correspAuthors=Jing DONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292130419584037592, articleId=1292130419034583766, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=西他沙星抗菌活性、药代动力学及临床应用研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

西他沙星作为第四代氟喹诺酮类抗菌药物，对革兰氏阴性菌、革兰氏阳性菌、非典型病原菌及厌氧菌等均具有良好的抗菌活性，对氟喹诺酮类耐药菌株、耐甲氧西林金黄色葡萄球菌、青霉素不敏感肺炎链球菌以及肠球菌等也具有抑制作用，在临床上广泛用于上呼吸道和下呼吸道感染、泌尿生殖系统感染、口腔感染和中耳炎等疾病的治疗。西他沙星在50~200 mg剂量范围内呈现线性药代动力学特征，口服后吸收迅速，在全身各组织器官广泛分布，并主要以原型药物从尿液排出，腹泻、恶心、肝功能异常是其常见药物不良反应。近年来，有临床研究表明，西他沙星对多重耐药菌引起的呼吸机相关性肺炎、医院获得性肺炎、肺结核、男性生殖支原体感染、脓肿分枝杆菌感染、牙源性感染、幽门螺杆菌感染、难治性分枝杆菌皮肤感染也有效，但仍需更多临床研究评估其疗效和安全性，同时需要开展在老年、肝功能不全等特殊人群中的药代动力学研究。本文系统综述了西他沙星的药理作用机制、抗菌活性、药代动力学/药效学特征及临床应用研究现状，旨在为临床安全有效地使用西他沙星提供参考依据。

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庞莹莹（2000-），女，硕士研究生，主要从事药物代谢动力学方向的研究

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庞莹莹（2000-），女，硕士研究生，主要从事药物代谢动力学方向的研究

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