Article(id=1292126385787654967, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.04.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1764518400000, receivedDateStr=2025-12-01, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996536919, onlineDateStr=2026-08-06, pubDate=1772208000000, pubDateStr=2026-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996536919, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996536919, creator=13701087609, updateTime=1785996536919, updator=13701087609, issue=Issue{id=1292126355785802497, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1772208000000', pubDateStr='2026-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996529766, creator='13701087609', updateTime=1786014519902, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201811952292026, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201811952292027, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=573, endPage=580, ext={EN=ArticleExt(id=1292126386441966392, articleId=1292126385787654967, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Current research status on psoralen flavonoids for treating bone and joint diseases, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Bone and joint diseases encompass conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and gouty arthritis. With high prevalence rates and a significant burden of disability, they have become a major global public health issue. Current treatment approaches primarily rely on drug interventions and surgical procedures, with relatively limited options for comprehensive intervention strategies. Psoralea corylifolia L. (Buguzhi), a traditional Chinese medicinal herb, is rich in various flavonoid small-molecule compounds. Its multi-targeted, multi-step regulatory advantages have drawn significant attention in the prevention and treatment of bone and joint diseases. Existing evidence indicates that these compounds exhibit comprehensive effects including osteogenesis promotion, osteoclast inhibition, anti-inflammation, antioxidant activity, and metabolic regulation, However, its key active substances and functional networks have yet to be systematically elucidated. Based on this, this paper aims to systematically elucidate the pharmacological actions and molecular mechanisms of psoralen flavonoids in the treatment of osteoarthritis, with the goal of providing novel research perspectives and potential strategies for the clinical prevention and treatment of this condition. Furthermore, it explores the prospects for clinical translation and the primary challenges encountered.

, authors=Ze-yang ZHANG¹, ABUDUKEREMU Dawuti¹, Yu-lin JIN¹, Hui ZHAO², Qi FU², Chao ZHANG², authorsList=Ze-yang ZHANG, ABUDUKEREMU Dawuti, Yu-lin JIN, Hui ZHAO, Qi FU, Chao ZHANG, authorCompany=null, correspAuthors=Chao ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126386660070201, articleId=1292126385787654967, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=补骨脂黄酮治疗骨关节疾病的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

骨关节疾病涵盖骨质疏松症、骨关节炎、类风湿关节炎、痛风性关节炎等，患病率高、致残负担重，已成为全球重要公共卫生问题。现有治疗手段主要依赖药物干预与手术治疗，整体干预手段相对有限。补骨脂（Psoralea corylifolia L.）为我国传统中药材，富含多种黄酮类小分子化合物，具有多靶点、多环节调控优势，在骨与关节疾病中的防治中备受关注。现有证据显示，该类化合物兼具成骨促进、破骨抑制、抗炎、抗氧化及代谢调节等综合效应，但其关键活性物质基础及作用网络尚未系统阐明。基于此，本文旨在系统阐述补骨脂黄酮在骨关节疾病治疗中的药理作用及分子机制，以期为骨关节疾病的临床防治提供新的研究思路及潜在策略，并进一步探讨其临床转化应用前景及面临的主要挑战。

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张泽阳（2000-），男，硕士研究生，主要从事中药材小分子化合物防治骨质疏松的研究和工作

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张泽阳（2000-），男，硕士研究生，主要从事中药材小分子化合物防治骨质疏松的研究和工作

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