Article(id=1292126395765907527, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.04.016, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1765987200000, receivedDateStr=2025-12-18, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996539297, onlineDateStr=2026-08-06, pubDate=1772208000000, pubDateStr=2026-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996539297, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996539297, creator=13701087609, updateTime=1785996539297, updator=13701087609, issue=Issue{id=1292126355785802497, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1772208000000', pubDateStr='2026-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996529766, creator='13701087609', updateTime=1786014519902, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201811952292026, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201811952292027, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=552, endPage=558, ext={EN=ArticleExt(id=1292126395954651208, articleId=1292126395765907527, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of new atypical antipsychotic drugs breziprazole, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Brexpiprazole, a novel atypical antipsychotic drug, has therapeutic effects in the treatment and prevention of relapse of schizophrenia. It exerts its efficacy through partial agonism of dopamine D₂ receptor and 5-hydroxytryptamine receptor 1A (5-HT_1A), as well as antagonism of 5-HT_2A receptor. In terms of pharmacokinetics, it features high oral bioavailability, a long half-life, and minimal influence of food on its absorption. Multiple clinical trials have confirmed its effectiveness in the acute treatment (2-4mg every day) and maintenance treatment (1-4mg every day) of schizophrenia. Regarding safety, common adverse reactions include akathisia and weight gain, with a relatively low risk of metabolic abnormalities. No systematic review of brexpiprazole has been published in China. This article conducts a systematic search for the first time and reviews it from aspects such as its mechanism of action, pharmacokinetic characteristics, clinical efficacy, and safety, providing a reference for rational clinical use.

, authors=Hong-yu ZHANG^{1, 2}, Nan WANG^{1, 2}, Sha SHA^{1, 2}, Fei JIA^{1, 2}, authorsList=Hong-yu ZHANG, Nan WANG, Sha SHA, Fei JIA, authorCompany=null, correspAuthors=Fei JIA, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126397774979145, articleId=1292126395765907527, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=新型非典型抗精神病药布瑞哌唑的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

布瑞哌唑作为一种新型非典型抗精神病药物，在精神分裂症的治疗和复发预防中具有疗效，该药通过对多巴胺D₂受体、5-羟色胺（5-HT₁A）受体的部分激动作用以及对5-HT₂A受体等的拮抗作用发挥疗效。药代动力学方面，具有口服生物利用度高、半衰期长、食物对其吸收影响小等特点。多项临床试验证实其在精神分裂症急性期治疗（每日2~4 mg）和维持治疗（每日1~4 mg）中的有效性；安全性上，常见不良反应为静坐不能和体重增加，代谢异常风险较低。布瑞哌唑在国内尚无系统综述发表，本文首次进行系统检索，从布瑞哌唑的作用机制、药代动力学特点、临床疗效及安全性等方面进行综述，为临床合理用药提供参考。

, authors=张红玉^{1, 2}, 王楠^{1, 2}, 沙莎^{1, 2}, 贾菲^{1, 2}, authorsList=张红玉, 王楠, 沙莎, 贾菲, authorCompany=null, correspAuthors=贾菲, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=+AR4FuUH5+e72UcYfTU4MQ==, magXml=fovNP/a8vmqBXKRoPoX+vw==, pdfUrl=null, pdf=IBxQr3VonAjQPq6AI/WiOw==, pdfFileSize=1668146, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=5XUY7/sIUYJ8e20aHEgENg==, mapNumber=null, fund=null)}, authors=[Author(id=1292126398127300689, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126398215381076, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, authorId=1292126398127300689, language=EN, stringName=Hong-yu ZHANG, firstName=Hong-yu, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126398295072853, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, authorId=1292126398127300689, language=CN, stringName=张红玉, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088
^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088, bio={"content":"

张红玉（1991-），女，主管药师，从事精神药理学与中药学的工作和研究

"}, bioImg=null, bioContent=

张红玉（1991-），女，主管药师，从事精神药理学与中药学的工作和研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126397967917130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=1., ext=[AuthorCompanyExt(id=1292126397976305739, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China), AuthorCompanyExt(id=1292126397984694348, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088)]), AuthorCompany(id=1292126398039220301, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=2., ext=[AuthorCompanyExt(id=1292126398047608910, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China), AuthorCompanyExt(id=1292126398055997519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088)])]), Author(id=1292126398353793111, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126398433484890, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, authorId=1292126398353793111, language=EN, stringName=Nan WANG, firstName=Nan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126398496399451, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, authorId=1292126398353793111, language=CN, stringName=王楠, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088
^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126397967917130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=1., ext=[AuthorCompanyExt(id=1292126397976305739, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China), AuthorCompanyExt(id=1292126397984694348, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088)]), AuthorCompany(id=1292126398039220301, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=2., ext=[AuthorCompanyExt(id=1292126398047608910, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China), AuthorCompanyExt(id=1292126398055997519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088)])]), Author(id=1292126398559314013, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1292126398647394400, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, authorId=1292126398559314013, language=EN, stringName=Sha SHA, firstName=Sha, middleName=null, lastName=SHA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126398727086177, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, authorId=1292126398559314013, language=CN, stringName=沙莎, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088
^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126397967917130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=1., ext=[AuthorCompanyExt(id=1292126397976305739, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China), AuthorCompanyExt(id=1292126397984694348, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088)]), AuthorCompany(id=1292126398039220301, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=2., ext=[AuthorCompanyExt(id=1292126398047608910, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China), AuthorCompanyExt(id=1292126398055997519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088)])]), Author(id=1292126398848720995, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=jiafei@mail.ccmu.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1292126398940995686, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, authorId=1292126398848720995, language=EN, stringName=Fei JIA, firstName=Fei, middleName=null, lastName=JIA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1292126399003910247, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, authorId=1292126398848720995, language=CN, stringName=贾菲, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088
^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1292126397967917130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=1., ext=[AuthorCompanyExt(id=1292126397976305739, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China), AuthorCompanyExt(id=1292126397984694348, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088)]), AuthorCompany(id=1292126398039220301, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=2., ext=[AuthorCompanyExt(id=1292126398047608910, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China), AuthorCompanyExt(id=1292126398055997519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088)])])], keywords=[Keyword(id=1292126399100379240, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, language=EN, orderNo=1, keyword=brexpiprazole), Keyword(id=1292126399175876713, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, language=EN, orderNo=2, keyword=schizophrenia), Keyword(id=1292126399238791274, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, language=EN, orderNo=3, keyword=dopamine receptors), Keyword(id=1292126399297511531, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, language=EN, orderNo=4, keyword=atypical antipsychotics), Keyword(id=1292126399377203308, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, language=CN, orderNo=1, keyword=布瑞哌唑), Keyword(id=1292126399461089389, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, language=CN, orderNo=2, keyword=精神分裂症), Keyword(id=1292126399524003950, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, language=CN, orderNo=3, keyword=多巴胺受体), Keyword(id=1292126399586918511, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, language=CN, orderNo=4, keyword=非典型抗精神病药)], refs=null, funds=[Fund(id=1292126399670804592, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, awardId=LCYX-2024-14, language=CN, fundingSource=北京药学会临床药学研究基金资助项目(LCYX-2024-14), fundOrder=null, country=null), Fund(id=1292126399754690673, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, awardId=YGLX202537, language=CN, fundingSource=北京市医院管理中心“扬帆3.0”医工结合培育基金资助项目(YGLX202537), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1292126397967917130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=1., ext=[AuthorCompanyExt(id=1292126397976305739, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.Beijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders; National Clinical Research Center for Mental Disorders; National Center for Mental Disorders; Beijing Anding Hospital, Capital Medical University, Beijing 100088, China), AuthorCompanyExt(id=1292126397984694348, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126397967917130, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.首都医科大学附属北京安定医院，国家精神疾病医学中心，精神心理疾病国家临床医学研究中心，精神疾病创新药智能研发北京市重点实验室，北京 100088)]), AuthorCompany(id=1292126398039220301, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, xref=2., ext=[AuthorCompanyExt(id=1292126398047608910, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Beijing Key Laboratory of Critical Bridging Technologies for Chronic Disease Drug Development, Beijing 100088, China), AuthorCompanyExt(id=1292126398055997519, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1292126395765907527, companyId=1292126398039220301, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.慢病新药创制关键桥接技术北京市重点实验室，北京 100088)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1788948995538, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1304509895005466898, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995591, updatedTime=1788948995591, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1304509895047409939, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1788948995601, updatedTime=1788948995601, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2026.04.016, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2026.04.016, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2026.04.016, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2026.04.016, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1772208000000, fullTextJson=null, articleText=null, reference=null)