Article(id=1292126372646904705, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.04.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1764777600000, receivedDateStr=2025-12-04, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996533786, onlineDateStr=2026-08-06, pubDate=1772208000000, pubDateStr=2026-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996533786, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996533786, creator=13701087609, updateTime=1785996533786, updator=13701087609, issue=Issue{id=1292126355785802497, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1772208000000', pubDateStr='2026-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996529766, creator='13701087609', updateTime=1786014519902, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201811952292026, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201811952292027, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126355785802497, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=507, endPage=515, ext={EN=ArticleExt(id=1292126372936311682, articleId=1292126372646904705, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Analysis of pharmacogenomic characteristics and clinical trial of genotype-guided therapy in patients with hypertension, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the distribution patterns of pharmacogenomic characteristics in hypertensive patients treated and to evaluate the differential benefits of genotype-guided therapy in calcium channel blocker (CCB) strategy versus beta-blocker strategy.
Methods In the first phase, pharmacogenomic data of patients with primary hypertension treated at our hospital were analyzed. In the second phase, treatment-naive hypertensive patients were enrolled and randomly assigned in a 1∶1∶1∶1 ratio to four groups: genotype-guided CCB strategy, standard CCB strategy, genotype-guided beta-blocker strategy, and standard beta-blocker strategy. Seven key pharmacogenomic loci, including adrenergic beta-1 receptor (ADRB1) rs1801253 (1165G>C) and cytochrome P450 3A5 (CYP3A5) rs776746, were genotyped using polymerase chain reaction (PCR)-melting curve method. Primary outcomes included time to blood pressure control, incidence of treatment-related adverse events (TRAEs), and length of hospital stay.
Results In the retrospective phase, 2 783 patients were enrolled. The C allele frequency of ADRB1 rs1801253 was 76.02% (4 231 cases/5 566 cases), and the G allele frequency of CYP3A5*3 was 72.97% (4 062 cases/5 566 cases). In the prospective phase, 300 patients were enrolled. The genotype-guided therapy significantly shortened time to blood pressure control (mean difference: -2.10 days, 95% confidence interval (CI): -2.80 to -1.40, P<0.001), with a significant interaction between therapy approach and treatment strategy (P<0.05). Specifically, in the CCB strategy, genotype-guided therapy reduced control time by 3.20 days (95% CI: -4.10 to -2.30) versus standard therapy, whereas in the beta-blocker strategy, the reduction was only 0.90 days (95% CI: -1.70 to -0.10). Genotype-guided therapy also significantly lowered TRAEs incidence [12.67% (19 cases/150 cases) vs. 25.33% (38 cases/150 cases), P<0.001].
Conclusion Hypertensive patients at our hospital exhibited a distinct pharmacogenomic profile. Genotype-guided therapy demonstrates substantially greater clinical benefits when applied to CCB strategy than to beta-blocker strategy, providing robust evidence for precision hypertension management within this single-center clinical setting.
, authors=Si-yu SUN, Nan LI, authorsList=Si-yu SUN, Nan LI, authorCompany=null, correspAuthors=Si-yu SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126373175387011, articleId=1292126372646904705, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=高血压患者药物基因组学特征分析及基因导向治疗的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究高血压患者药物基因组学特征分布规律，评估基因导向治疗在钙通道阻滞剂（CCB）策略与β受体阻滞剂策略中的差异化获益。
方法 第1阶段分析我院收治的原发性高血压患者的药物基因组学特征；第2阶段纳入我院初治的高血压患者，按1∶1∶1∶1比例随机分配至4组：基因导向CCB策略组、标准CCB策略组、基因导向β受体阻滞剂策略组和标准β受体阻滞剂策略组。通过聚合酶链反应（PCR）-熔解曲线法检测β1-肾上腺素受体基因（ADRB1）rs1801253、细胞色素P450 3A5基因（CYP3A5）rs776746等7个关键位点，比较4组患者血压达标时间、住院日和治疗相关不良反应（TRAEs）发生率等指标。
结果 在第1阶段研究中，纳入2 783例高血压患者，ADRB1 1165G>C位点C等位基因频率为76.02%（4 231例/5 566例），CYP3A5*3的G等位基因频率为72.97%（4 062例/5 566例）。在第2阶段研究中，纳入300例患者，每组75例患者。基因导向治疗组（n=150）较标准治疗组（n=150）显著缩短血压达标时间[平均差-2.10 d，95%置信区间（95%CI）：-2.80~-1.40，P<0.001]，且与治疗策略存在显著交互作用（P<0.05）。在CCB策略中，基因导向治疗较标准治疗缩短达标时间3.20 d（95% CI：-4.10~-2.30），而在β受体阻滞剂策略中仅缩短0.90 d（95% CI：-1.70~-0.10）。基因导向治疗组和标准TRAEs分别为12.67%（19例/150例）和25.33%（38例/150例），2组间比较在统计学上差异有统计学意义（P<0.001）。
结论 本院收治的高血压患者具有独特的药物基因组学特征谱，基因导向治疗在CCB策略中的获益显著大于β受体阻滞剂策略，为高血压精准治疗提供重要循证依据。
, authors=孙思雨, 李楠, authorsList=孙思雨, 李楠, authorCompany=null, correspAuthors=孙思雨, authorNote=
孙思雨（1986-），男，副主任药师，主要从事药物基因组学、医院药学的工作和研究
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