Article(id=1292126536778412507, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.03.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1768147200000, receivedDateStr=2026-01-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996572918, onlineDateStr=2026-08-06, pubDate=1771257600000, pubDateStr=2026-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996572918, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996572918, creator=13701087609, updateTime=1785996572918, updator=13701087609, issue=Issue{id=1292126460546929080, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1771257600000', pubDateStr='2026-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996554742, creator='13701087609', updateTime=1786014541627, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292201903060963536, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292201903060963537, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126460546929080, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=350, endPage=355, ext={EN=ArticleExt(id=1292126536958767580, articleId=1292126536778412507, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of polymyxin B combined with sitafloxacin in the treatment of extensively drug-resistant
Pseudomonas aeruginosa hospital-acquired pneumonia, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of polymyxin B injection combined with sitafloxacin tablets in the treatment of hospital-acquired pneumonia (HAP) caused by extensively drug-resistant Pseudomonas aeruginosa.
Methods Patients with pandrug-resistant pseudomonas aeruginosa (PDR-PA) pneumonia admitted to our hospital were enrolled. According to treatment regimen, patients were divided into control group and treatment group. Patients in the control group received polymyxin B injection at an initial dose of 2.0-2.5 mg·kg-1, followed by a maintenance dose of 1.25-1.5 mg·kg-1 every 12 h after the loading dose. Patients in the treatment group received additional oral sitafloxacin tablets at 50-100 mg twice daily on the basis of the above regimen. The duration of antibacterial treatment for both groups was 7 days in principle, with a maximum of 14 days. Clinical efficacy, bacterial clearance rate, inflammatory markers, arterial blood gas and oxygenation parameters, prognosis, and safety profiles were compared between two groups.
Results A total of 128 patients were included in this study, with 64 cases in each group. After treatment, the total effective rates in the control group and the treatment group were 76.56% (49 cases/64 cases) and 95.31% (61 cases/64 cases), showing a statistically significant difference (P<0.05). After treatment, the total bacterial clearance rates in control and treatment groups were were 73.44% (47 cases/64 cases) and 93.75% (60 cases/64 cases), respectively; the serum levels of procalcitonin (PCT) were (1.42±0.31) and (0.81±0.18) ng·mL-1, respectively; C-reactive protein (CRP) were (68.14±15.62) and (38.27±12.46) mg·L-1, respectively; and interleukin-6 (IL-6) were (61.73±14.85) and (38.92±11.77) pg·mL-1, respectively; the arterial partial pressure of oxygen (PaO2) were (75.36±7.15) and (88.57±6.93) mmHg, respectively; the arterial partial pressure of carbon dioxide (PaCO2) were (45.27±4.86) and (39.68±4.25) mmHg, respectively; and the oxygenation index (PaO2/FiO2) were 236.48±28.51 and 278.36±31.22, respectively. All of these indicators in treatment group showed statistically significant differences compared to control group (all P<0.05). The 28-day all-cause mortality rates of the control group and the treatment group were 10.94% (7 cases/64 cases) and 4.69% (3 cases/64 cases), respectively; and the length of hospital stay were (15.82±4.27) and (14.97±3.58) d, respectively; with no significant differences between the two groups (all P>0.05). The incidences of total adverse drug reactions in the treatment group and the control group were 18.75% (12 cases/64 cases) and 25.00% (16 cases /64 cases), respectively, with no statistically significant difference between the two groups (P>0.05).
Conclusion Polymyxin B injection combined with sitafloxacin tablets significantly improves bacterial clearance, reduces inflammatory response, and enhances oxygenation in patients with xDR-PA HAP, while maintaining good safety, indicating its potential clinical utility.
, authors=Ying-chao LIU, Wen-qing LE, Wan-ting LI, Li-hong SONG, Hao YU, authorsList=Ying-chao LIU, Wen-qing LE, Wan-ting LI, Li-hong SONG, Hao YU, authorCompany=null, correspAuthors=Wan-ting LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126538808455645, articleId=1292126536778412507, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=多黏菌素B联合西他沙星治疗广泛耐药铜绿假单胞菌医院获得性肺炎的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察多黏菌素B注射液联合西他沙星片治疗广泛耐药铜绿假单胞菌医院获得性肺炎HAP的临床效果和安全性。
方法 将本院收治的广泛耐药铜绿假单胞菌HAP患者纳入为研究对象，根据治疗方式不同分为对照组和试验组。对照组接受静脉输注多黏菌素B治疗，初始剂量为2.0~2.5 mg·kg-1，负荷后维持约1.25~1.5 mg·kg-1，每12 h 1次；试验组在上述基础上加用口服西他沙星片，每次50～100 mg、每日2次。2组患者抗菌治疗疗程原则上为7 d，最长不超过14 d。对比2组患者治疗后的临床疗效、细菌清除率、炎症指标、动脉血气及氧合指标、预后及安全性评价。
结果 本研究共入组128例，对照组和试验组各64例。治疗后，对照组和试验组的总有效率分别为76.56%（49例/64例）和95.31%（61例/64例），在统计学上差异有统计学意义（P<0.05）。治疗后，对照组和试验组的细菌总清除率分别为73.44%（47例/64例）和93.75%（60例/64例），血清降钙素原（PCT）水平分别为（1.42±0.31）和（0.81±0.18）ng·mL-1，C反应蛋白（CRP）水平分别为（68.14±15.62）和（38.27±12.46）mg·L-1，白细胞介素-6（IL-6）水平分别为（61.73±14.85）和（38.92±11.77）pg·mL-1，动脉血氧分压（PaO2）水平分别为（75.36±7.15）和（88.57±6.93）mmHg，动脉血二氧化碳分压（PaCO2）水平分别为（45.27±4.86）和（39.68±4.25）mmHg，氧合指数（PaO2/FiO2）分别为236.48±28.51和278.36±31.22，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.05）。对照组和试验组28天全因死亡率分别为10.94%（7例/64例）和4.69%（3例/64例），住院时间分别为（15.82±4.27）和（14.97±3.58）d，2组比较，在统计学上差异均无统计学意义（均P>0.05）。试验组与对照组患者总药物不良反应发生率分别为18.75%（12例/64例）和25.00%（16例/64例），在统计学上差异无统计学意义（P>0.05）。
结论 多黏菌素B注射液联合西他沙星片可显著提高广泛耐药铜绿假单胞菌HAP患者的细菌清除率，减轻炎症反应，改善氧合功能，且安全性良好，具有一定临床应用价值。
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刘应超（1982-），男，主治医师，主要从事重症医学方面的工作和研究
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