Article(id=1292126466490262087, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.02.019, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1764950400000, receivedDateStr=2025-12-06, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996556160, onlineDateStr=2026-08-06, pubDate=1769529600000, pubDateStr=2026-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996556160, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996556160, creator=13701087609, updateTime=1785996556160, updator=13701087609, issue=Issue{id=1292126409196064779, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1769529600000', pubDateStr='2026-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996542500, creator='13701087609', updateTime=1786014671444, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202447569707674, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202447569707675, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=265, endPage=273, ext={EN=ArticleExt(id=1292126466855166536, articleId=1292126466490262087, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Analysis of disease burden attributable to high body mass index in global and China from 1990 to 2021, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the trends of the disease burden attributable to high body mass index (BMI) globally and in China from 1990 to 2021, to provide evidence for obesity prevention and control strategies.
Methods Based on the Global Burden of Disease (GBD) 2021 database, data on high BMI-related deaths, disability-adjusted life years (DALYs), age-standardized mortality rates, and age-standardized DALYs rates globally and in China from 1990 to 2021 were extracted. The Joinpoint software was used to calculate the average annual percentage change (AAPC) of age-standardized mortality rates and DALYs. Disease burden ranking were performed using the GBD Compare tool.
Results Globally, deaths attributable to high BMI increased from 1.4595 million to 3.7091 million (increase of 154.13%, AAPC=0.29%, P<0.001); in China, from 0.1420 million to 0.5756 million (increase of 305.23%, AAPC=1.12%, P<0.001). Males showed higher increases than in females in both. Globally, the number of DALYs increased from 48.0421 million person-years to 128.5201 million person-years (increase of 167.52%), while in China, it increased from 5.4339 million person-years to 20.8652 million person-years (increase of 283.9%). For China, the top five diseases for mortality rates and DALYs rates attributable to high BMI were ischemic heart disease, hypertensive heart disease, diabetes, stroke, and chronic kidney disease. Alzheimer's disease showed an AAPC of 9.87% (P<0.001) for age-standardized mortality rate, rising from the 17th to the 6th place.
Conclusion From 1990 to 2021, disease burden attributable to high BMI significantly increased globally and in China, with China’s growth rate far exceeding the global average. Comprehensive life-cycle obesity prevention and control should be strengthened, with special focus on high-burden diseases such as cardiovascular diseases, diabetes, and cancers. New directions for prevention and control of stroke and Alzheimer’s disease should be emphasized.
, authors=A-ning SUN, Bin ZHU, Ming-fen WU, Ke-fu YU, Zhi-gang ZHAO, authorsList=A-ning SUN, Bin ZHU, Ming-fen WU, Ke-fu YU, Zhi-gang ZHAO, authorCompany=null, correspAuthors=Zhi-gang ZHAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126467660472905, articleId=1292126466490262087, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=1990-2021年全球与中国高体质指数导致的疾病负担分析, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=
目的 探讨1990-2021年全球及中国高体质指数（BMI）导致的疾病负担变化趋势，为肥胖防控策略提供依据。
方法 基于全球疾病负担（GBD）2021数据库，提取1990-2021年全球及中国的高BMI相关死亡人数、伤残调整生命年（DALYs）、年龄标化死亡率和年龄标化DALYs率，采用Joinpoint软件计算年龄标化死亡率和DALYs率的平均年度变化百分比（AAPC），通过GBD Compare工具进行疾病负担排序。
结果 全球高BMI相关死亡人数从145.95万增至370.91万（增幅154.13%，AAPC=0.29%，P<0.001），中国从14.20万增至57.56万（增幅305.23%，AAPC=1.12%，P<0.001），男性增幅均高于女性。全球DALYs数从4 804.21万人年增至12 852.01万人年（增幅167.52%），中国从543.39万人年增至2 086.52万人年（增幅283.9%）。中国高BMI相关死亡率和DALYs率的前五位疾病均为缺血性心脏病、高血压性心脏病、糖尿病、脑卒中和慢性肾疾病，阿尔茨海默病年龄标化死亡率AAPC达9.87%（P<0.001），位次从第17位升至第6位。
结论 1990-2021年全球及中国高BMI相关疾病负担显著增加，中国增速远高于全球。需加强全生命周期肥胖防控，重点关注心血管疾病、糖尿病和肿瘤等高负担疾病，关注脑卒中和阿尔茨海默病防控新方向。
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孙阿宁（1988-），女，主管药师，主要从事临床药学相关工作
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