Article(id=1292126493136678956, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.02.018, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1765814400000, receivedDateStr=2025-12-16, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996562512, onlineDateStr=2026-08-06, pubDate=1769529600000, pubDateStr=2026-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996562512, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996562512, creator=13701087609, updateTime=1785996562512, updator=13701087609, issue=Issue{id=1292126409196064779, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1769529600000', pubDateStr='2026-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996542500, creator='13701087609', updateTime=1786014671444, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202447569707674, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202447569707675, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=258, endPage=264, ext={EN=ArticleExt(id=1292126493333811245, articleId=1292126493136678956, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research progress on clinical adverse reactions of hydroxychloroquine, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

As an antimalarial drug, hydroxychloroquine has anti-inflammatory and immunomodulatory effects, and can treat rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and other diseases. Because of its potential to inhibit virus therapy, it is widely used during the period of novel coronavirus pneumonia. Hydroxychloroquine also has drug side effects, which can cause damage to multiple systems such as the nervous system, cardiovascular system, retina, digestive system, skin, and blood system. Its toxic mechanism is related to Cytochrome P450 3A4 (CYP3A4) enzyme metabolism, blocking inward rectifier K⁺current(IK1), interfering with photoreceptors and retinal pigment epithelial (RPE) cells, and other effects. This study provides a review of the toxic side effects and molecular mechanisms caused by the application of hydroxychloroquine, providing theoretical support for the study of its toxic effects and rational clinical use.

, authors=Fan-meng LIU¹, Shan JIANG¹, Yuan-ting ZHOU¹, Shao-feng JIANG^{1, 2}, Jin-qing HUANG¹, authorsList=Fan-meng LIU, Shan JIANG, Yuan-ting ZHOU, Shao-feng JIANG, Jin-qing HUANG, authorCompany=null, correspAuthors=Shao-feng JIANG, Jin-qing HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126493572886574, articleId=1292126493136678956, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=羟氯喹的临床不良反应研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

羟氯喹是一种抗疟疾药物，具有抗炎和免疫调节作用，可以治疗类风湿关节炎（RA）和系统性红斑狼疮（SLE）等疾病，因其抑制病毒的治疗潜力得以在新型冠状病毒肺炎期间被广泛应用。羟氯喹存在药物副作用，其毒性作用机制与细胞色素P450 3A4（CYP3A4）酶代谢、阻滞内向整流钾电流（IK1）、干扰光感受器和视网膜色素上皮（RPE）细胞等作用有关，可以导致神经系统、心血管系统、视网膜、消化系统、皮肤、血液系统等多系统损伤。本研究对羟氯喹导致的毒副作用及其分子机制进行综述，为羟氯喹的毒性作用研究以及临床合理用药提供理论支持。

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