Article(id=1292126489680573432, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.02.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1769011200000, receivedDateStr=2026-01-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996561689, onlineDateStr=2026-08-06, pubDate=1769529600000, pubDateStr=2026-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996561689, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996561689, creator=13701087609, updateTime=1785996561689, updator=13701087609, issue=Issue{id=1292126409196064779, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1769529600000', pubDateStr='2026-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996542500, creator='13701087609', updateTime=1786014671444, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202447569707674, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202447569707675, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=243, endPage=246, ext={EN=ArticleExt(id=1292126489915454458, articleId=1292126489680573432, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=A case report of anaphylactic shock in a child after several days of safe use of piperacillin-tazobactam, columnId=1292126489844151289, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Adverse Drug Reactions, runingTitle=null, highlight=null, articleAbstract=

A 20-month-old male infant was admitted to the department of infectious diseases of our hospital due to infectious fever and left cervical lymphadenitis. He received treatment with piperacillin sodium and tazobactam sodium for injection. After 7 consecutive days of medication (a total of 23 administrations) without adverse reactions, the infant suddenly developed symptoms of anaphylactic shock during the 24th administration, including irritability, incessant crying, pale complexion, cyanosis of the lips, cold extremities, and unmeasurable blood pressure. Medical staff immediately discontinued the infusion of piperacillin sodium and tazobactam sodium for injection and initiated rescue measures such as intramuscular injection of epinephrine. Eventually, the infant was successfully resuscitated. This case reminds medical personnel that the sensitization period of β-lactam antibiotics can last for several days or even months, which is concealed throughout the entire treatment course. The absence of adverse reactions during initial medication does not rule out subsequent risks. It is necessary to strengthen medical staff’s attention to medication monitoring during each administration to ensure the safety of pediatric medication.

, authors=Ping LI1, Hong-li YU1, Wei XI2, Lu LIU1, Mei-xing YAN1, Chang LIU1, authorsList=Ping LI, Hong-li YU, Wei XI, Lu LIU, Mei-xing YAN, Chang LIU, authorCompany=null, correspAuthors=Chang LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126490200667132, articleId=1292126489680573432, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=1例儿童安全使用哌拉西林钠他唑巴坦钠数天后突发过敏性休克的病例分析, columnId=1292126489986757627, journalTitle=中国临床药理学杂志, columnName=药物不良反应, runingTitle=null, highlight=null, articleAbstract=

1例1岁8月患儿,男性,因感染性发热、左侧颈部淋巴结炎入住我院感染科,接受注射用哌拉西林钠他唑巴坦钠治疗,在连续用药7 d(累计给药23次)且无不良反应的情况下,第24次给药时患儿突然出现烦躁、哭闹不止,面色苍白,口唇发绀,肢端冰凉,血压测不出等过敏性休克症状。医务人员立即停止输注注射用哌拉西林钠他唑巴坦钠,肌注肾上腺素等抢救措施,最终患儿转危为安。此案例提醒医务人员应注意β-内酰胺类抗生素致敏期可持续数天甚至数月,隐匿存在于治疗全程,起初用药安全不能排除后续风险,需强化医务人员对每次用药监测的重视,以保障儿童用药安全。

, authors=李萍1, 于洪丽1, 奚玮2, 刘璐1, 闫美兴1, 刘畅1, authorsList=李萍, 于洪丽, 奚玮, 刘璐, 闫美兴, 刘畅, authorCompany=null, correspAuthors=刘畅, authorNote=

李萍(1984-),女,副主任药师,主要从事临床药学方向的工作和研究

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刘畅,副主任药师 Tel: (0532)68661613 E-mail:
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1例儿童安全使用哌拉西林钠他唑巴坦钠数天后突发过敏性休克的病例分析
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李萍 1 , 于洪丽 1 , 奚玮 2 , 刘璐 1 , 闫美兴 1 , 刘畅 1
中国临床药理学杂志 | 药物不良反应 2026,42(2): 243-246
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中国临床药理学杂志 |药物不良反应 2026 , 42 (2) : 243 -246
1例儿童安全使用哌拉西林钠他唑巴坦钠数天后突发过敏性休克的病例分析
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李萍1, 于洪丽1, 奚玮2, 刘璐1, 闫美兴1, 刘畅1
作者信息
  • 1.青岛大学 附属妇女儿童医院 药学部,山东 青岛 266034
  • 2.青岛市食品药品检验研究院,山东 青岛 266071
通讯作者:
刘畅,副主任药师 Tel: (0532)68661613 E-mail:
作者简介:

李萍(1984-),女,副主任药师,主要从事临床药学方向的工作和研究

A case report of anaphylactic shock in a child after several days of safe use of piperacillin-tazobactam
Ping LI1, Hong-li YU1, Wei XI2, Lu LIU1, Mei-xing YAN1, Chang LIU1
Affiliations
  • 1.Dept. of Pharmacy, Qingdao Women and Children’s Hospital, Qingdao 266034, Shandong Province, China
  • 2.Qingdao Institute for Food and Drug Control, Qingdao 266071, Shandong Province, China
出版时间: 2026-01-28 doi: 10.13699/j.cnki.1001-6821.2026.02.015
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1例1岁8月患儿,男性,因感染性发热、左侧颈部淋巴结炎入住我院感染科,接受注射用哌拉西林钠他唑巴坦钠治疗,在连续用药7 d(累计给药23次)且无不良反应的情况下,第24次给药时患儿突然出现烦躁、哭闹不止,面色苍白,口唇发绀,肢端冰凉,血压测不出等过敏性休克症状。医务人员立即停止输注注射用哌拉西林钠他唑巴坦钠,肌注肾上腺素等抢救措施,最终患儿转危为安。此案例提醒医务人员应注意β-内酰胺类抗生素致敏期可持续数天甚至数月,隐匿存在于治疗全程,起初用药安全不能排除后续风险,需强化医务人员对每次用药监测的重视,以保障儿童用药安全。

注射用哌拉西林钠他唑巴坦钠  /  儿童  /  过敏性休克  /  药物不良反应  /  药物致敏期

A 20-month-old male infant was admitted to the department of infectious diseases of our hospital due to infectious fever and left cervical lymphadenitis. He received treatment with piperacillin sodium and tazobactam sodium for injection. After 7 consecutive days of medication (a total of 23 administrations) without adverse reactions, the infant suddenly developed symptoms of anaphylactic shock during the 24th administration, including irritability, incessant crying, pale complexion, cyanosis of the lips, cold extremities, and unmeasurable blood pressure. Medical staff immediately discontinued the infusion of piperacillin sodium and tazobactam sodium for injection and initiated rescue measures such as intramuscular injection of epinephrine. Eventually, the infant was successfully resuscitated. This case reminds medical personnel that the sensitization period of β-lactam antibiotics can last for several days or even months, which is concealed throughout the entire treatment course. The absence of adverse reactions during initial medication does not rule out subsequent risks. It is necessary to strengthen medical staff’s attention to medication monitoring during each administration to ensure the safety of pediatric medication.

piperacillin sodium and tazobactam sodium for injection  /  children  /  anaphylactic shock  /  adverse drug reactions  /  drug sensitization period
李萍, 于洪丽, 奚玮, 刘璐, 闫美兴, 刘畅. 1例儿童安全使用哌拉西林钠他唑巴坦钠数天后突发过敏性休克的病例分析. 中国临床药理学杂志, 2026 , 42 (2) : 243 -246 . DOI: 10.13699/j.cnki.1001-6821.2026.02.015
Ping LI, Hong-li YU, Wei XI, Lu LIU, Mei-xing YAN, Chang LIU. A case report of anaphylactic shock in a child after several days of safe use of piperacillin-tazobactam[J]. Chinese Journal of Clinical Pharmacology, 2026 , 42 (2) : 243 -246 . DOI: 10.13699/j.cnki.1001-6821.2026.02.015
  • 山东省药品不良反应监测中心项目(药品2025SDADR013)
  • 中华国际医学交流基金会资助项目(Z-2014-08-2309-7)
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doi: 10.13699/j.cnki.1001-6821.2026.02.015
  • 接收时间:2026-01-22
  • 首发时间:2026-08-06
  • 出版时间:2026-01-28
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  • 收稿日期:2026-01-22
基金
山东省药品不良反应监测中心项目(药品2025SDADR013)
中华国际医学交流基金会资助项目(Z-2014-08-2309-7)
作者信息
    1.青岛大学 附属妇女儿童医院 药学部,山东 青岛 266034
    2.青岛市食品药品检验研究院,山东 青岛 266071

通讯作者:

刘畅,副主任药师 Tel: (0532)68661613 E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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