Article(id=1292126445443248779, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2026.02.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1758470400000, receivedDateStr=2025-09-22, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785996551142, onlineDateStr=2026-08-06, pubDate=1769529600000, pubDateStr=2026-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785996551142, onlineIssueDateStr=2026-08-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785996551142, creator=13701087609, updateTime=1785996551142, updator=13701087609, issue=Issue{id=1292126409196064779, tenantId=1146029695717560320, journalId=1246415772164075586, year='2026', volume='42', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1769529600000', pubDateStr='2026-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785996542500, creator='13701087609', updateTime=1786014671444, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1292202447569707674, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1292202447569707675, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1292126409196064779, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=185, endPage=191, ext={EN=ArticleExt(id=1292126447154524812, articleId=1292126445443248779, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical study on atorvastatin combined with bivalirudin for patients with STEMI after PCI, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the clinical efficacy and safety of atorvastatin tablets combined with bivalirudin injection in patients with acute ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI).
Methods Patients with acute STEMI were divided into control group and treatment group according to whether combined medication was used. The control group was given an intravenous continuous bolus of bivalirudin for injection at a dose of 0.75 mg·kg-1 during the operation, and after the operation, intravenous pumping of bivalirudin was continued at a dose of 1.75 mg·(kg·h)-1 until 6 hours postoperatively. The treatment group was treated with atorvastatin combined with bivalirudin, where the administration method of bivalirudin was the same as that in the control group, and atorvastatin calcium tablets were administered orally at a dose of 20 mg each time, bid. Both groups received a 30-day treatment course, and relevant reexaminations were conducted after the course. The efficacy, myocardial function indicators, blood coagulation indicators, blood lipid indicators, and inflammatory factor indicators were compared between the two groups.
Results The trial recruited 118 patients, with 54 assigned to the control group and 64 to the treatment group. At 30 days postoperatively, the efficacy rates of the control group and the treatment group were 74.07% and 89.06%, respectively. At 30 days after surgery, the cardiac troponin T levels in the control group and the treatment group were (7.58±1.27) and (7.01±1.38) μg·L-1, respectively; the global longitudinal strain values were (16.87±1.05)% and (16.34±1.01)%, respectively; the fibrinogen degradation product levels were (4.09±0.80) and (3.82±0.51) μg·mL-1 , respectively; the D-dimer levels were (0.97±0.42) and (0.82±0.33) mg·L-1, respectively; the low-density lipoprotein cholesterol levels were (2.26±0.77) and (1.97±0.61) mmol·L-1, respectively; the β2-microglobulin levels were (2.45±0.12) and (2.36±0.14) mg·L-1, respectively; and the macrophage inflammatory protein-1α levels were (26.22±3.90) and (24.20±4.33) pg·mL-1, respectively. The differences in the above indicators between the treatment group and the control group were all statistically significant (all P<0.05). The incidence of adverse reactions was 7.41% (4 cases/54cases) in the control group and 4.69% (3 cases/64cases) in the treatment group, and the incidence of major adverse cardiovascular events was 5.56% (3 cases/54 cases) and 1.56% (1 case/64 cases), respectively, with no statistically significant differences (all P>0.05).
Conclusion Atorvastatin tablets combined with bivalirudin injection have a significant efficacy in STEMI patients after PCI. It can achieve the goals of improving myocardial function and coagulation function, effectively controlling the patient′s blood lipid level, reducing the inflammatory response, and exhibit good safety.
, authors=Shuai LIU, Ya WANG, Yuan LI, Jing LI, Hui-jing ZHANG, authorsList=Shuai LIU, Ya WANG, Yuan LI, Jing LI, Hui-jing ZHANG, authorCompany=null, correspAuthors=Hui-jing ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1292126447917888141, articleId=1292126445443248779, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=阿托伐他汀联合比伐芦定用于STEMI患者PCI术后的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨阿托伐他汀片剂联合比伐芦定注射剂用于急性ST段抬高型心肌梗死患者（STEMI）经皮冠状动脉介入治疗（PCI）术后的临床疗效和安全性。
方法 将急性STEMI患者根据是否联合用药分为对照组和试验组。对照组术中予注射用比伐芦定0.75 mg·kg-1静脉持续推注，术后继续以1.75 mg·kg-1·h-1静脉泵入至术后6 h；试验组予以阿托伐他汀联合比伐芦定治疗，比伐芦定用法与对照组一致，阿托伐他汀钙片用药方法：每次口服20 mg，bid。2组疗程均为30 d，结束后行相关复查。比较2组疗效、心肌功能指标、血凝指标、血脂指标、炎症因子指标。
结果 共纳入118例患者，其中对照组54例，试验组64例。对照组和试验组术后30 d的疗效分别为74.07%和89.06%（P<0.05）。对照组和试验组术后30 d的肌钙蛋白T分别为（7.58±1.27）和（7.01±1.38）μg·L-1；整体纵向应变分别为（16.87±1.05）%和（16.34±1.01）%；纤维蛋白原降解物分别为（4.09±0.80）和（3.82±0.51）μg·mL-1；D-二聚体分别为（0.97±0.42）和（0.82±0.33）mg·L-1；低密度脂蛋白胆固醇分别为（2.26±0.77）和（1.97±0.61）mmol·L-1；β2-微球蛋白分别为（2.45±0.12）和（2.36±0.14）mg·L-1；巨噬细胞炎症蛋白-1α分别为（26.22±3.90）和（24.20±4.33）pg·mL-1，试验组的上述指标与对照组比较，在统计学上差异均有统计学意义（均P<0.01）。对照组和试验组不良反应发生率分别为7.41%（4例/54例）和4.69%（3例/64例），主要不良心血管事件发生率分别为5.56%（3例/54例）和1.56%（1例/64例），在统计学上差异均无统计学意义（均P>0.05）。
结论 阿托伐他汀片剂联合比伐芦定注射剂用于STEMI患者PCI术后的疗效显著，能够达到改善心肌功能及凝血功能的目标，有效控制患者血脂水平，并降低炎症反应，且安全性较好。
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刘帅（1987-），男，主治医师，主要从事冠心病及冠心病介入诊疗方面的工作和研究
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